Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Hb M Milwaukee: direct detection of the beta-globin gene mutation in three generations of an afflicted family.

Literature DB >> 6311728

Hb M Milwaukee: direct detection of the beta-globin gene mutation in three generations of an afflicted family.

Abstract

Chromosomal DNA from three individuals with familial hemoglobin M (Hb M) Milwaukee was studied by restriction endonuclease analysis. The segregation of the mutant beta-globin gene could be followed through three generations by direct Sst I analysis at the gene level. Various restriction endonucleases were used to confirm the positions of Sst I sites in the delta-beta A- and delta-beta Mi-globin gene regions.

Mesh：

Substances：

Year: 1983 PMID： 6311728 DOI： 10.1007/bf00292370

Source DB: PubMed Journal: Hum Genet ISSN： 0340-6717 Impact factor: 4.132

Keyword Cloud
References

15 in total

1. Detection of specific sequences among DNA fragments separated by gel electrophoresis.

Authors: E M Southern
Journal: J Mol Biol Date: 1975-11-05 Impact factor: 5.469

2. Polymorphic DNA region adjacent to the 5' end of the human insulin gene.

Authors: G I Bell; J H Karam; W J Rutter
Journal: Proc Natl Acad Sci U S A Date: 1981-09 Impact factor: 11.205

3. Nonrandom association of polymorphic restriction sites in the beta-globin gene cluster.

Authors: S E Antonarakis; C D Boehm; P J Giardina; H H Kazazian
Journal: Proc Natl Acad Sci U S A Date: 1982-01 Impact factor: 11.205

4. The nucleotide sequence of the human beta-globin gene.

Authors: R M Lawn; A Efstratiadis; C O'Connell; T Maniatis
Journal: Cell Date: 1980-10 Impact factor: 41.582

5. Analysis of the Hb M Milwaukee mutation at the DNA level.

Authors: J Horst; R Schäfer; E Kleihauer; E Kohne
Journal: Br J Haematol Date: 1983-08 Impact factor: 6.998

6. The structure and evolution of the human beta-globin gene family.

Authors: A Efstratiadis; J W Posakony; T Maniatis; R M Lawn; C O'Connell; R A Spritz; J K DeRiel; B G Forget; S M Weissman; J L Slightom; A E Blechl; O Smithies; F E Baralle; C C Shoulders; N J Proudfoot
Journal: Cell Date: 1980-10 Impact factor: 41.582

Hb M Milwaukee: direct detection of the beta-globin gene mutation in three generations of an afflicted family.

1. Detection of specific sequences among DNA fragments separated by gel electrophoresis.

2. Polymorphic DNA region adjacent to the 5' end of the human insulin gene.

3. Nonrandom association of polymorphic restriction sites in the beta-globin gene cluster.

4. The nucleotide sequence of the human beta-globin gene.

5. Analysis of the Hb M Milwaukee mutation at the DNA level.

6. The structure and evolution of the human beta-globin gene family.

7. Hb M Milwaukee in a German family.

8. Polymorphism of DNA sequence adjacent to human beta-globin structural gene: relationship to sickle mutation.

9. Insertion of synthetic copies of human globin genes into bacterial plasmids.

10. Human beta-globin messenger RNA. III. Nucleotide sequences derived from complementary DNA.