| Literature DB >> 6985477 |
A Efstratiadis, J W Posakony, T Maniatis, R M Lawn, C O'Connell, R A Spritz, J K DeRiel, B G Forget, S M Weissman, J L Slightom, A E Blechl, O Smithies, F E Baralle, C C Shoulders, N J Proudfoot.
Abstract
We present the results of a detailed comparison of the primary structure of human beta-like globin genes and their flanking sequences. Among the sequences located 5' to these genes are two highly conserved regions which include the sequences ATA and CCAAT located 31 +/- 1 and 77 +/- 10 bp, respectively, 5' to the mRNA capping site. Similar sequences are found in the corresponding locations in most other eucaryotic structural genes. Calculation of the divergence times of individual beta-like globin gene pairs provides the first description of the evolutionary relationships within a gene family based entirely on direct nucleotide sequence comparisons. In addition, the evolutionary relationship of the embryonic epsilon-globin gene to the other human beta-like globin genes is defined for the first time. Finally, we describe a model for the involvement of short direct repeat sequences in the generation of deletions in the noncoding and coding regions of beta-like globin genes during evolution.Entities:
Mesh：
Substances：
Year: 1980 PMID： 6985477 DOI： 10.1016/0092-8674(80)90429-8
Source DB: PubMed Journal: Cell ISSN： 0092-8674 Impact factor: 41.582