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Literature DB >> 4357181

Antiviral effects of aphidicolin, a new antibiotic produced by Cephalosporium aphidicola.

R A Bucknall, H Moores, R Simms, B Hesp.

Abstract

Aphidicolin is an antibiotic of novel structure produced by the mold Cephalosporium aphidicola. It is a potent inhibitor of cellular deoxyribonucleic acid synthesis, and it also strongly inhibits the growth of herpes simplex virus both in tissue culture and in the rabbit eye. Aphidicolin is active against iododeoxyuridine-resistant herpes virus, and does not itself readily induce the formation of drug-resistant strains of herpesvirus.

Entities: Chemical Species

Mesh：

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Year: 1973 PMID： 4357181 PMCID： PMC444544 DOI： 10.1128/AAC.4.3.294

Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN： 0066-4804 Impact factor: 5.191

6 in total

1. SOME BIOLOGIC ASPECTS OF HERPESVIRUS-CELL INTERACTIONS IN THE PRESENCE OF 5-IODO, 2-DESOXYURIDINE (IDU). DEMONSTRATION OF A CYTOTOXIC EFFECT BY HERPESVIRUS.

Authors: K O SMITH
Journal: J Immunol Date: 1963-11 Impact factor: 5.422

2. Activity of 1-beta-D-arabinofuranosylcytosine hydrochloride against herpes simplex keratitis.

Authors: G E UNDERWOOD
Journal: Proc Soc Exp Biol Med Date: 1962-12

3. Incorporation of iododeoxyuridine into the deoxyribonucleic acid of mouse Ehrlich-ascites-tumor cells in vivo.

Authors: W H PRUSOFF
Journal: Biochim Biophys Acta Date: 1960-04-08

4. Clinical studies with systemic administration of antimetabolites of pyrimidine nucleosides in viral infections.

Authors: P Calabresi
Journal: Ann N Y Acad Sci Date: 1965-07-30 Impact factor: 5.691

5. The effects of substituted benzimidazoles on the growth of viruses and the nucleic acid metabolism of host cells.

Authors: R A Bucknall
Journal: J Gen Virol Date: 1967-01 Impact factor: 3.891

6. Herpes keratitis in rabbits: pathogenesis and effect of antiviral nucleosides.

Authors: G E Underwood; G A Elliott; D A Buthala
Journal: Ann N Y Acad Sci Date: 1965-07-30 Impact factor: 5.691

6 in total

24 in total

1. Further characterization of a cell-free system for measuring replicative and repair DNA synthesis with cultured human fibroblasts and evidence for the involvement of DNA polymerase alpha in DNA repair.

Authors: G Ciarrocchi; J G Jose; S Linn
Journal: Nucleic Acids Res Date: 1979-11-10 Impact factor: 16.971

2. Viral gene expression patterns in human herpesvirus 6B-infected T cells.

Authors: Bodil Øster; Per Höllsberg
Journal: J Virol Date: 2002-08 Impact factor: 5.103

3. Site of the base change in the vaccinia virus DNA polymerase gene which confers aphidicolin resistance.

Authors: F M DeFilippes
Journal: J Virol Date: 1989-09 Impact factor: 5.103

4. The first murine zygotic transcription is promiscuous and uncoupled from splicing and 3' processing.

Authors: Ken-Ichiro Abe; Ryoma Yamamoto; Vedran Franke; Minjun Cao; Yutaka Suzuki; Masataka G Suzuki; Kristian Vlahovicek; Petr Svoboda; Richard M Schultz; Fugaku Aoki
Journal: EMBO J Date: 2015-04-20 Impact factor: 11.598

5. Mechanism of inhibition of herpes simplex virus and vaccinia virus DNA polymerases by aphidicolin, a highly specific inhibitor of DNA replication in eucaryotes.

Authors: G Pedrali-Noy; S Spadari
Journal: J Virol Date: 1980-11 Impact factor: 5.103

6. Susceptibility of vaccine strains of varicella-zoster virus to antiviral compounds.

Authors: S R Preblud; A M Arbeter; E A Proctor; S E Starr; S A Plotkin
Journal: Antimicrob Agents Chemother Date: 1984-04 Impact factor: 5.191

7. Susceptibility of phosphonoformic acid-resistant herpes simplex virus variants to arabinosylnucleosides and aphidicolin.

Authors: K F Bastow; D D Derse; Y C Cheng
Journal: Antimicrob Agents Chemother Date: 1983-06 Impact factor: 5.191