Literature DB >> 6308762

Ivermectin: a potent new antiparasitic agent.

W C Campbell, M H Fisher, E O Stapley, G Albers-Schönberg, T A Jacob.   

Abstract

Ivermectin is the 22,23-dihydro derivative of avermectin B1, a macrocyclic lactone produced by an actinomycete, Streptomyces avermitilis. It is active at extremely low dosage against a wide variety of nematode and arthropod parasites, apparently by virtue of its action on the mediation of neurotransmission by gamma-aminobutyric acid. It is now in commercial use in various countries for the treatment and control of parasites in cattle, horses, and sheep, and is expected to become available for use in swine and dogs. Since studies with the drug in man are in a preliminary stage, it is not yet known whether ivermectin will be useful in human medicine.

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Year:  1983        PMID： 6308762     DOI： 10.1126/science.6308762

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  114 in total

Review 1.  Anthelminthic agents: some recent developments and their clinical application.

Authors:  G C Cook
Journal:  Postgrad Med J       Date:  1991-01       Impact factor: 2.401

2.  Decrease in adverse reactions after repeated ivermectin treatment in onchocerciasis.

Authors:  A Van der Lelij; A Rothova; N Klaassen-Broekema; W R Wilson; R F Barbe; J S Stilma
Journal:  Doc Ophthalmol       Date:  1990-10       Impact factor: 2.379

3.  Autophagy response in the liver of pigeon exposed to avermectin.

Authors:  Xian-Song Wang; Ci Liu; Pervez Ahmed Khoso; Weijia Zheng; Ming Li; Shu Li
Journal:  Environ Sci Pollut Res Int       Date:  2016-02-17       Impact factor: 4.223

4.  Total synthesis of avermectin B1a revisited.

Authors:  Shuji Yamashita; Daisuke Hayashi; Aoi Nakano; Yujiro Hayashi; Masahiro Hirama
Journal:  J Antibiot (Tokyo)       Date:  2015-09-09       Impact factor: 2.649

5.  Ivermectin is not an agonist at a GABA receptor in tick salivary glands.

Authors:  L O Lomas; W R Kaufman
Journal:  Exp Appl Acarol       Date:  1991-09       Impact factor: 2.132

6.  Ivermectin in senegalese peulh sheep: influence of sex on plasma disposition.

Authors:  T Bengone Ndong; Y Kane; E H M Diouf; M Alvinerie
Journal:  Vet Res Commun       Date:  2007-01-27       Impact factor: 2.459

7.  Anthelmintic action of eprinomectin in lactating Anglo-Nubian goats in Brazil.

Authors:  Ana Carolina de Souza Chagas; Luiz da Silva Vieira; Wladimir Rodrigues Aragão; Andrine Maria do Carmo Navarro; Luciana Cristine Vasques Villela
Journal:  Parasitol Res       Date:  2006-10-10       Impact factor: 2.289

8.  Ivermectin activates GIRK channels in a PIP2 -dependent, Gβγ -independent manner and an amino acid residue at the slide helix governs the activation.

Authors:  I-Shan Chen; Michihiro Tateyama; Yuko Fukata; Motonari Uesugi; Yoshihiro Kubo
Journal:  J Physiol       Date:  2017-07-30       Impact factor: 5.182

9.  A review of the pharmacology and clinical uses of ivermectin.

Authors:  T B Barragry
Journal:  Can Vet J       Date:  1987-08       Impact factor: 1.008

10.  Flubendazole and ivermectin in vitro combination therapy produces a marked effect on Echinococcus granulosus protoscoleces and metacestodes.

Authors:  M Celina Elissondo; L Ceballos; L Alvarez; S Sánchez Bruni; C Lanusse; G Denegri
Journal:  Parasitol Res       Date:  2009-05-15       Impact factor: 2.289
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