Literature DB >> 1660804

Ivermectin is not an agonist at a GABA receptor in tick salivary glands.

L O Lomas1, W R Kaufman.   

Abstract

The avermectins, broad-spectrum anti-parasitic agents which are effective against ticks, act principally by stimulating gamma-aminobutyric acid (GABA) receptors directly or indirectly. GABA is known to potentiate dopamine-induced fluid secretion in the salivary glands of female ixodid ticks. We thus tested whether 10 microM ivermectin would have an effect similar to GABA in the isolated salivary gland preparation of Dermacentor andersoni. Ivermectin was not an agonist at this GABA receptor.

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Year:  1991        PMID： 1660804     DOI： 10.1007/bf01204406

Source DB:  PubMed          Journal:  Exp Appl Acarol        ISSN： 0168-8162            Impact factor:   2.132


  7 in total

1.  Avermectin B1a irreversibly blocks postsynaptic potentials at the lobster neuromuscular junction by reducing muscle membrane resistance.

Authors:  L C Fritz; C C Wang; A Gorio
Journal:  Proc Natl Acad Sci U S A       Date:  1979-04       Impact factor: 11.205

2.  Studies on the mechanism of action of avermectin B1a: stimulation of release of gamma-aminobutyric acid from brain synaptosomes.

Authors:  S S Pong; C C Wang; L C Fritz
Journal:  J Neurochem       Date:  1980-02       Impact factor: 5.372

3.  Potentiation of salivary fluid secretion in ixodid ticks: a new receptor system for gamma-aminobutyric acid.

Authors:  P J Lindsay; W R Kaufman
Journal:  Can J Physiol Pharmacol       Date:  1986-08       Impact factor: 2.273

4.  Regulation of body volume by salivation in a tick challenged with fluid loads.

Authors:  W R Kaufman; A A Aeschlimann; P A Diehl
Journal:  Am J Physiol       Date:  1980-01

5.  Evidence for multiple receptors mediating fluid secretion in salivary glands of ticks.

Authors:  W R Kaufman; D L Wong
Journal:  Eur J Pharmacol       Date:  1983-01-28       Impact factor: 4.432

6.  The effect of avermectins on feeding, salivary fluid secretion, and fecundity in some ixodid ticks.

Authors:  W R Kaufman; S G Ungarian; A E Noga
Journal:  Exp Appl Acarol       Date:  1986-04       Impact factor: 2.132

7.  Ivermectin: a potent new antiparasitic agent.

Authors:  W C Campbell; M H Fisher; E O Stapley; G Albers-Schönberg; T A Jacob
Journal:  Science       Date:  1983-08-26       Impact factor: 47.728
  7 in total
  2 in total

1.  Impact of ivermectin on the ultrastructure of the testis of Argas (Persicargas) persicus (Ixodoidea: Argasidae).

Authors:  Ashraf A Montasser; G G Gadelhak; S Tariq
Journal:  Exp Appl Acarol       Date:  2005       Impact factor: 2.132

2.  In vitro study of ivermectin efficiency against the cattle tick, Rhipicephalus (Boophilus) annulatus, among cattle herds in El-Beheira, Egypt.

Authors:  Gaber E Batiha; Ali H El-Far; Amany A El-Mleeh; Abdelwahab A Alsenosy; Eman K Abdelsamei; Mohamed M Abdel-Daim; Yasser S El-Sayed; Hazem M Shaheen
Journal:  Vet World       Date:  2019-08-25
  2 in total

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