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Literature DB >> 17422843

A review of the pharmacology and clinical uses of ivermectin.

Abstract

The avermectins were introduced in 1981 and constitute a potent new class of anthelmintic agents. They are naturally-derived products of microbial action displaying an exceptionally wide range of antiparasitic efficacy against internal and external parasites of domestic animals. This paper reviews their isolation and chemistry, mechanism of action, chemical efficacy and safety in cattle, sheep, swine, horses and dogs.

Entities: Species

Year: 1987 PMID： 17422843 PMCID： PMC1680605

Source DB: PubMed Journal: Can Vet J ISSN： 0008-5286 Impact factor: 1.008

67 in total

1. Efficacy of injectable and oral paste formulations of ivermectin against gastrointestinal parasites in ponies.

Authors: B J Torbert; B S Kramer; T R Klei
Journal: Am J Vet Res Date: 1982-08 Impact factor: 1.156

2. Residual protection against cattle scabies afforded by ivermectin.

Authors: W P Meleney; F C Wright; F S Guillot
Journal: Am J Vet Res Date: 1982-10 Impact factor: 1.156

3. Anthelmintic efficiency of ivermectin against naturally occurring gastrointestinal nematodes of sheep.

Authors: J Armour; K Bairden; J M Preston
Journal: Vet Rec Date: 1982-07-24 Impact factor: 2.695

4. Efficacy of ivermectin against naturally acquired and experimentally induced nematode infections in sheep.

Authors: R B Wescott; B R LeaMaster
Journal: Am J Vet Res Date: 1982-03 Impact factor: 1.156

5. Evaluation of the potential of systemic slow release chemical treatments for control of the cattle tick (Boophilus microplus) using ivermectin.

Authors: J Nolan; H J Schnitzerling; P Bird
Journal: Aust Vet J Date: 1981-11 Impact factor: 1.281

6. Activity of ivermectin against canine intestinal helminths.

Authors: D L Anderson; E L Roberson
Journal: Am J Vet Res Date: 1982-09 Impact factor: 1.156

7. Effectiveness of ivermectin against later 4th-stage Strongylus vulgaris in ponies.

Authors: J O Slocombe; B M McCraw; P W Pennock; J Vasey
Journal: Am J Vet Res Date: 1982-09 Impact factor: 1.156

8. Anthelmintic efficacy of ivermectin given intramuscularly in horses.

Authors: J A DiPietro; K S Todd; T F Lock; T A McPherron
Journal: Am J Vet Res Date: 1982-01 Impact factor: 1.156

9. Effectiveness of ivermectin in the treatment of equine Parascaris equorum and Oxyuris equi infections.

Authors: T A Yazwinski; D Hamm; M Williams; T Greenway; W Tilley
Journal: Am J Vet Res Date: 1982-06 Impact factor: 1.156

10. Antiparasitic effectiveness of ivermectin in the horse.

Authors: T A Yazwinski; D Hamm; T Greenway; W Tilley
Journal: Am J Vet Res Date: 1982-06 Impact factor: 1.156

10 in total

1. Bioconversion of avermectin into 27-OH avermectin.

Authors: M Chartrain; R White; R Goegelman; K Gbewonyo; R Greasham
Journal: J Ind Microbiol Date: 1990-12

2. Ivermectin activates GIRK channels in a PIP₂ -dependent, G_βγ -independent manner and an amino acid residue at the slide helix governs the activation.

Authors: I-Shan Chen; Michihiro Tateyama; Yuko Fukata; Motonari Uesugi; Yoshihiro Kubo
Journal: J Physiol Date: 2017-07-30 Impact factor: 5.182

A review of the pharmacology and clinical uses of ivermectin.

1. Efficacy of injectable and oral paste formulations of ivermectin against gastrointestinal parasites in ponies.

2. Residual protection against cattle scabies afforded by ivermectin.

3. Anthelmintic efficiency of ivermectin against naturally occurring gastrointestinal nematodes of sheep.

4. Efficacy of ivermectin against naturally acquired and experimentally induced nematode infections in sheep.

5. Evaluation of the potential of systemic slow release chemical treatments for control of the cattle tick (Boophilus microplus) using ivermectin.

6. Activity of ivermectin against canine intestinal helminths.

7. Effectiveness of ivermectin against later 4th-stage Strongylus vulgaris in ponies.

8. Anthelmintic efficacy of ivermectin given intramuscularly in horses.

9. Effectiveness of ivermectin in the treatment of equine Parascaris equorum and Oxyuris equi infections.

10. Antiparasitic effectiveness of ivermectin in the horse.

1. Bioconversion of avermectin into 27-OH avermectin.

2. Ivermectin activates GIRK channels in a PIP₂ -dependent, G_βγ -independent manner and an amino acid residue at the slide helix governs the activation.

3. Ivermectin overdose and toxicosis in neonatal pigs.

4. Efficacy of Ivermectin against Cheyletiella yasguri Infestation in Dogs.

5. Comparative cost-effectiveness of ivermectin versus topical organophosphate in feedlot calves.

6. Ocular onchocerciasis: current management and future prospects.

7. Disease behaviours of sows naturally infected with Taenia solium in Tanzania.

8. Hair cortisol and dehydroepiandrosterone concentrations in naturally Taenia solium infected pigs in Tanzania.

9. Severe seizures in pigs naturally infected with Taenia solium in Tanzania.

Review 10. Assessment of Avermectins-Induced Toxicity in Animals.