Literature DB >> 6307980

Amikacin resistance mediated by multiresistance transposon Tn2424.

J F Meyer, B A Nies, B Wiedemann.   

Abstract

Tn2424, a multiresistance transposon 25 kilobases long, was isolated from IncFII plasmid NR79. Tn2424 transposed resistance to sulfonamides, streptomycin and spectinomycin, mercuric chloride, chloramphenicol, and amikacin with a frequency of 6 X 10(-5). Resistance to amikacin was mediated by a 6'-N-acetyltransferase, which conferred higher levels of resistance in Pseudomonas aeruginosa than in Escherichia coli. A restriction analysis and cloning experiments resulted in a physical and functional map of Tn2424. Comparison by a heteroduplex technique revealed that Tn2424 includes the total sequence of Tn21 and two additional DNA fragments that are 1.8 and 4 kilobases long.

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Year:  1983        PMID： 6307980      PMCID： PMC217747          DOI： 10.1128/jb.155.2.755-760.1983

Source DB:  PubMed          Journal:  J Bacteriol        ISSN： 0021-9193            Impact factor:   3.490


  28 in total

1.  Filamentous coliphage M13 as a cloning vehicle: insertion of a HindII fragment of the lac regulatory region in M13 replicative form in vitro.

Authors:  J Messing; B Gronenborn; B Müller-Hill; P Hans Hopschneider
Journal:  Proc Natl Acad Sci U S A       Date:  1977-09       Impact factor: 11.205

2.  Transposition of TnA does not generate deletions.

Authors:  P M Bennett; J Grinsted; M H Richmond
Journal:  Mol Gen Genet       Date:  1977-07-20

Review 3.  Pedigrees of some mutant strains of Escherichia coli K-12.

Authors:  B J Bachmann
Journal:  Bacteriol Rev       Date:  1972-12

Review 4.  The electronmicroscopy of DNA.

Authors:  H B Younghusband; R B Inman
Journal:  Annu Rev Biochem       Date:  1974       Impact factor: 23.643

5.  Enzymatic acetylation of aminoglycoside antibiotics by Escherichia coli carrying an R factor.

Authors:  R Benveniste; J Davies
Journal:  Biochemistry       Date:  1971-05-11       Impact factor: 3.162

6.  Supercoiled circular DNA-protein complex in Escherichia coli: purification and induced conversion to an opern circular DNA form.

Authors:  D B Clewell; D R Helinski
Journal:  Proc Natl Acad Sci U S A       Date:  1969-04       Impact factor: 11.205

7.  Chromosome mapping in Pseudomonas aeruginosa.

Authors:  J M Pemberton; B W Holloway
Journal:  Genet Res       Date:  1972-06       Impact factor: 1.588

8.  Construction and characterization of new cloning vehicles. II. A multipurpose cloning system.

Authors:  F Bolivar; R L Rodriguez; P J Greene; M C Betlach; H L Heyneker; H W Boyer; J H Crosa; S Falkow
Journal:  Gene       Date:  1977       Impact factor: 3.688

9.  Mapping of the resistance genes of the R plasmid NR1.

Authors:  T Miki; A M Easton; R H Rownd
Journal:  Mol Gen Genet       Date:  1978-01-17

10.  Properties of a R factor which originated in Pseudomonas aeruginosa 1822.

Authors:  J Grinsted; J R Saunders; L C Ingram; R B Sykes; M H Richmond
Journal:  J Bacteriol       Date:  1972-05       Impact factor: 3.490
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  24 in total

1.  The chloramphenicol acetyltransferase gene of Tn2424: a new breed of cat.

Authors:  R Parent; P H Roy
Journal:  J Bacteriol       Date:  1992-05       Impact factor: 3.490

2.  Cloning, sequencing, and use as a molecular probe of a gene encoding an aminoglycoside 6'-N-acetyltransferase of broad substrate profile.

Authors:  F J Terán; J E Suárez; M C Mendoza
Journal:  Antimicrob Agents Chemother       Date:  1991-04       Impact factor: 5.191

3.  Characterization of the nonenzymatic chloramphenicol resistance (cmlA) gene of the In4 integron of Tn1696: similarity of the product to transmembrane transport proteins.

Authors:  L Bissonnette; S Champetier; J P Buisson; P H Roy
Journal:  J Bacteriol       Date:  1991-07       Impact factor: 3.490

4.  Nosocomial spread of an amikacin resistance gene on both a mobilized, nonconjugative plasmid and a conjugative plasmid.

Authors:  J D Hopkins; A Flores; M del Pilar Pla; S Lester; T F O'Brien
Journal:  Antimicrob Agents Chemother       Date:  1991-08       Impact factor: 5.191

5.  Structural and functional characterization of tnpI, a recombinase locus in Tn21 and related beta-lactamase transposons.

Authors:  J Mercier; J Lachapelle; F Couture; M Lafond; G Vézina; M Boissinot; R C Levesque
Journal:  J Bacteriol       Date:  1990-07       Impact factor: 3.490

6.  Heterogeneity of 6'-N-acetyltransferases of type 4 conferring resistance to amikacin and related aminoglycosides in members of the family Enterobacteriaceae.

Authors:  G Tran Van Nhieu; E Collatz
Journal:  Antimicrob Agents Chemother       Date:  1988-08       Impact factor: 5.191

7.  Sequencing and expression of the 6'-N-acetyltransferase gene of transposon Tn1331 from Klebsiella pneumoniae.

Authors:  K Nobuta; M E Tolmasky; L M Crosa; J H Crosa
Journal:  J Bacteriol       Date:  1988-08       Impact factor: 3.490

8.  Precise insertion of antibiotic resistance determinants into Tn21-like transposons: nucleotide sequence of the OXA-1 beta-lactamase gene.

Authors:  M Ouellette; L Bissonnette; P H Roy
Journal:  Proc Natl Acad Sci U S A       Date:  1987-11       Impact factor: 11.205

9.  The region of the IncN plasmid R46 coding for resistance to beta-lactam antibiotics, streptomycin/spectinomycin and sulphonamides is closely related to antibiotic resistance segments found in IncW plasmids and in Tn21-like transposons.

Authors:  R M Hall; C Vockler
Journal:  Nucleic Acids Res       Date:  1987-09-25       Impact factor: 16.971

10.  Primary structure of an aminoglycoside 6'-N-acetyltransferase AAC(6')-4, fused in vivo with the signal peptide of the Tn3-encoded beta-lactamase.

Authors:  G Tran van Nhieu; E Collatz
Journal:  J Bacteriol       Date:  1987-12       Impact factor: 3.490
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