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Literature DB >> 146819

Mapping of the resistance genes of the R plasmid NR1.

Abstract

The drug resistance genes on the r-determinants component of the composite R plasmid NR1 were mapped on the EcoRI restriction endonuclease fragments of the R plasmid by cloning the fragments using the plasmid RSF2124 as a vector. The sulfonamide (Su) and streptomycin/spectinomycin (Sm/Sp) resistance genes are located on EcoRI fragment G of NR1. The expression of resistance to mercuric ions (Mer) requires both EcoRI fragment H and I of NR1. The expression of chloramphenicol (Cm) and fusidic acid (Fus) resistance requires EcoRI fragments A and J of NR1. The kan fragment of the related R plasmid R6-5 can substitute for Eco RI fragment J of NR1 in the expression of Cm and Fus resistance. The structural genes for Cm and Fus resistance appear to be a part of an operon whose expression is controlled by the same promoter.

Entities: Chemical Gene

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Substances：

Year: 1978 PMID： 146819 DOI： 10.1007/bf00267192

Source DB: PubMed Journal: Mol Gen Genet ISSN： 0026-8925

29 in total

1. Uniform nomenclature for bacterial plasmids: a proposal.

Authors: R P Novick; R C Clowes; S N Cohen; R Curtiss; N Datta; S Falkow
Journal: Bacteriol Rev Date: 1976-03

2. Plasmid co-integrates of prophage lambda and R factor R100.

Authors: W B Dempsey; N S Willetts
Journal: J Bacteriol Date: 1976-04 Impact factor: 3.490

3. Involvement of IS1 in the dissociation of the r-determinant and RTF components of the plasmid R100.1.

Authors: M Chandler; B Allet; E Gallay; E Boy de La Tour; L Caro
Journal: Mol Gen Genet Date: 1977-06-24

4. Mapping of the drug resistance genes carried by the r-determinant of the R100.1 plasmid.

Authors: D Lane; M Chandler
Journal: Mol Gen Genet Date: 1977-11-29

5. Plasmid-determined fusidic acid resistance in the Enterobacteriaceae.

Authors: N Datta; R W Hedges; D Becker; J Davies
Journal: J Gen Microbiol Date: 1974-07

6. Construction of biologically functional bacterial plasmids in vitro.

Authors: S N Cohen; A C Chang; H W Boyer; R B Helling
Journal: Proc Natl Acad Sci U S A Date: 1973-11 Impact factor: 11.205

7. Analysis of endonuclease R-EcoRI fragments of DNA from lambdoid bacteriophages and other viruses by agarose-gel electrophoresis.

Authors: R B Helling; H M Goodman; H W Boyer
Journal: J Virol Date: 1974-11 Impact factor: 5.103

8. Non-chromosomal antibiotic resistance in bacteria. II. Molecular nature of R-factors isolated from Proteus mirabilis and Escherichia coli.

Authors: S N Cohen; C A Miller
Journal: J Mol Biol Date: 1970-06-28 Impact factor: 5.469

9. A complementation analysis of the restriction and modification of DNA in Escherichia coli.

Authors: H W Boyer; D Roulland-Dussoix
Journal: J Mol Biol Date: 1969-05-14 Impact factor: 5.469

10. The generation of a ColE1-Apr cloning vehicle which allows detection of inserted DNA.

Authors: M So; R Gill; S Falkow
Journal: Mol Gen Genet Date: 1975-12-30

45 in total

1. Lambda transducing phages derived from a FinO- R100::lambda cointegrate plasmid: proteins encoded by the R100 replication/incompatibility region and the antibiotic resistance determinant.

Authors: W B Dempsey; S A McIntire
Journal: Mol Gen Genet Date: 1979-11

10. Transition of deletion mutants of the composite resistance plasmid NR1 in Escherichia coli and Salmonella typhimurium.

Authors: G A Huffman; R H Rownd
Journal: J Bacteriol Date: 1984-08 Impact factor: 3.490

Mapping of the resistance genes of the R plasmid NR1.

1. Uniform nomenclature for bacterial plasmids: a proposal.

2. Plasmid co-integrates of prophage lambda and R factor R100.

3. Involvement of IS1 in the dissociation of the r-determinant and RTF components of the plasmid R100.1.

4. Mapping of the drug resistance genes carried by the r-determinant of the R100.1 plasmid.

5. Plasmid-determined fusidic acid resistance in the Enterobacteriaceae.

6. Construction of biologically functional bacterial plasmids in vitro.

7. Analysis of endonuclease R-EcoRI fragments of DNA from lambdoid bacteriophages and other viruses by agarose-gel electrophoresis.

8. Non-chromosomal antibiotic resistance in bacteria. II. Molecular nature of R-factors isolated from Proteus mirabilis and Escherichia coli.

9. A complementation analysis of the restriction and modification of DNA in Escherichia coli.

10. The generation of a ColE1-Apr cloning vehicle which allows detection of inserted DNA.

1. Lambda transducing phages derived from a FinO- R100::lambda cointegrate plasmid: proteins encoded by the R100 replication/incompatibility region and the antibiotic resistance determinant.

2. Transcription of the stability operon of IncFII plasmid NR1.

3. Amplification of chloramphenicol resistance transposons carried by phage P1Cm in Escherichia coli.

4. Wide-host-range plasmids function in the genus thiobacillus.

Review 5. Genetic and physical map of plasmid NR1: comparison with other IncFII antibiotic resistance plasmids.

6. Rosanilins: indicator dyes for chloramphenicol-resistant enterobacteria containing chloramphenicol acetyltransferase.

7. Effect of gene amplification on mercuric ion reduction activity of Escherichia coli.

8. Gene copy number effects in the mer operon of plasmid NR1.

9. Asymmetric transcription of R plasmid NR1 in Proteus mirabilis.

10. Transition of deletion mutants of the composite resistance plasmid NR1 in Escherichia coli and Salmonella typhimurium.