Literature DB >> 6307920

Intracellular pools of thymidine reduce the antiviral action of acyclovir.

J Harmenberg.   

Abstract

Acyclovir inhibits herpes simplex virus (HSV) infections better in human fibroblasts than in green monkey kidney cells. Thymidine and acyclovir compete for the active site of HSV thymidine kinase. Large intracellular pools of thymidine found by high-performance liquid chromatography (HPLC) seemed to be responsible for the reduced activity of acyclovir. Such intracellular thymidine pools could not be measured previously, and the HPLC technique may help in evaluating the expected efficiency of acyclovir in cells and tissues prior to treatment.

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Year:  1983        PMID： 6307920     DOI： 10.1159/000149373

Source DB:  PubMed          Journal:  Intervirology        ISSN： 0300-5526            Impact factor:   1.763


  12 in total

1.  Comparative methods for detection of thymidine kinase-deficient herpes simplex virus type 1 strains.

Authors:  J Harmenberg; V A Sundqvist; H Gadler; B Levén; G Brännström; B Wahren
Journal:  Antimicrob Agents Chemother       Date:  1986-10       Impact factor: 5.191

2.  Strategic design and three-dimensional analysis of antiviral drug combinations.

Authors:  M N Prichard; L E Prichard; C Shipman
Journal:  Antimicrob Agents Chemother       Date:  1993-03       Impact factor: 5.191

3.  Kinetic analysis in cell culture of the reversal of antiherpes activity of nucleoside analogs by thymidine.

Authors:  A Larsson; G Brännström; B Oberg
Journal:  Antimicrob Agents Chemother       Date:  1983-11       Impact factor: 5.191

4.  Deoxythymidine pools in animal and human skin with reference to antiviral drugs.

Authors:  J Harmenberg; G Abele; M Malm
Journal:  Arch Dermatol Res       Date:  1985       Impact factor: 3.017

5.  Inhibiting effect of (RS)-9-[4-hydroxy-2-(hydroxymethyl)butyl]guanine on varicella-zoster virus replication in cell culture.

Authors:  G Abele; A Karlström; J Harmenberg; S Shigeta; A Larsson; B Lindborg; B Wahren
Journal:  Antimicrob Agents Chemother       Date:  1987-01       Impact factor: 5.191

6.  Oral acyclovir therapy of genital herpes simplex virus type 2 infections in guinea pigs.

Authors:  M N Ellis; D W Barry
Journal:  Antimicrob Agents Chemother       Date:  1985-02       Impact factor: 5.191

7.  Influence of acyclovir and bucyclovir on nucleotide pools in cells infected with herpes simplex virus type 1.

Authors:  A H Karlsson; J G Harmenberg; B E Wahren
Journal:  Antimicrob Agents Chemother       Date:  1986-05       Impact factor: 5.191

8.  Effects of ribonucleotide reductase inhibition on pyrimidine deoxynucleotide metabolism in acyclovir-treated cells infected with herpes simplex virus type 1.

Authors:  A Karlsson; J Harmenberg
Journal:  Antimicrob Agents Chemother       Date:  1988-07       Impact factor: 5.191

9.  Antiviral activities of guanosine analogs in guinea pig embryonic fibroblasts.

Authors:  J Harmenberg; K Stenberg
Journal:  Antimicrob Agents Chemother       Date:  1988-10       Impact factor: 5.191

Review 10.  Acyclovir. An updated review of its antiviral activity, pharmacokinetic properties and therapeutic efficacy.

Authors:  J J O'Brien; D M Campoli-Richards
Journal:  Drugs       Date:  1989-03       Impact factor: 9.546
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