Literature DB >> 2847642

Effects of ribonucleotide reductase inhibition on pyrimidine deoxynucleotide metabolism in acyclovir-treated cells infected with herpes simplex virus type 1.

A Karlsson1, J Harmenberg.   

Abstract

The pyrimidine metabolism of fibroblasts infected with herpes simplex virus type 1 was studied. Herpes simplex virus type 1 infection increased the dTTP pool and thymidylate synthetase activity but reduced thymidine excretion. Addition of acyclovir to infected cells increased thymidine excretion, the dTTP pool, and thymidylate synthetase activity. Addition of a virus-specific ribonucleotide reductase inhibitor (A723U) decreased all three. The synergy between the two compounds is discussed.

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Year:  1988        PMID： 2847642      PMCID： PMC172354          DOI： 10.1128/AAC.32.7.1100

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  20 in total

1.  Thymidine kinase from herpes simplex virus phosphorylates the new antiviral compound, 9-(2-hydroxyethoxymethyl)guanine.

Authors:  J A Fyfe; P M Keller; P A Furman; R L Miller; G B Elion
Journal:  J Biol Chem       Date:  1978-12-25       Impact factor: 5.157

2.  Deoxyribonucleotide metabolism in Herpes simplex virus infected HeLa cells.

Authors:  Y C Cheng; B Goz; W H Prusoff
Journal:  Biochim Biophys Acta       Date:  1975-05-16

3.  Selectivity of action of an antiherpetic agent, 9-(2-hydroxyethoxymethyl) guanine.

Authors:  G B Elion; P A Furman; J A Fyfe; P de Miranda; L Beauchamp; H J Schaeffer
Journal:  Proc Natl Acad Sci U S A       Date:  1977-12       Impact factor: 11.205

4.  Comparative methods for detection of thymidine kinase-deficient herpes simplex virus type 1 strains.

Authors:  J Harmenberg; V A Sundqvist; H Gadler; B Levén; G Brännström; B Wahren
Journal:  Antimicrob Agents Chemother       Date:  1986-10       Impact factor: 5.191

Review 5.  Reduction of ribonucleotides.

Authors:  L Thelander; P Reichard
Journal:  Annu Rev Biochem       Date:  1979       Impact factor: 23.643

Review 6.  Viral-associated and induced enzymes.

Authors:  S Kit
Journal:  Pharmacol Ther B       Date:  1979

7.  Phosphorylation of acyclovir (acycloguanosine) monophosphate by GMP kinase.

Authors:  W H Miller; R L Miller
Journal:  J Biol Chem       Date:  1980-08-10       Impact factor: 5.157

8.  Phosphorylation of acyclovir diphosphate by cellular enzymes.

Authors:  W H Miller; R L Miller
Journal:  Biochem Pharmacol       Date:  1982-12-01       Impact factor: 5.858

9.  Effect of acyclovir on the deoxyribonucleoside triphosphate pool levels in Vero cells infected with herpes simplex virus type 1.

Authors:  P A Furman; C U Lambe; D J Nelson
Journal:  Am J Med       Date:  1982-07-20       Impact factor: 4.965

10.  Influence of cells and virus multiplicity on the inhibition of herpesviruses with acycloguanosine.

Authors:  J Harmenberg; B Wahren; B Oberg
Journal:  Intervirology       Date:  1980       Impact factor: 1.763
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  8 in total

1.  Herpes simplex virus ribonucleotide reductase mutants are hypersensitive to acyclovir.

Authors:  D M Coen; D J Goldstein; S K Weller
Journal:  Antimicrob Agents Chemother       Date:  1989-08       Impact factor: 5.191

2.  2-Acetylpyridine 5-[(dimethylamino)thiocarbonyl]-thiocarbonohydrazone (A1110U), a potent inactivator of ribonucleotide reductases of herpes simplex and varicella-zoster viruses and a potentiator of acyclovir.

Authors:  T Spector; J A Harrington; R W Morrison; C U Lambe; D J Nelson; D R Averett; K Biron; P A Furman
Journal:  Proc Natl Acad Sci U S A       Date:  1989-02       Impact factor: 11.205

3.  Anticytomegaloviral activity of methotrexate associated with preferential accumulation of drug by cytomegalovirus-infected cells.

Authors:  M Wachsman; F M Hamzeh; H Saito; P S Lietman
Journal:  Antimicrob Agents Chemother       Date:  1996-02       Impact factor: 5.191

4.  Inactivators of herpes simplex virus ribonucleotide reductase: hematological profiles and in vivo potentiation of the antiviral activity of acyclovir.

Authors:  T Spector; D C Lobe; M N Ellis; T A Blumenkopf; G M Szczech
Journal:  Antimicrob Agents Chemother       Date:  1992-05       Impact factor: 5.191

5.  2-Acetylpyridine 5-[(dimethylamino)thiocarbonyl]-thiocarbonohydrazone (1110U81) potently inhibits human cytomegalovirus replication and potentiates the antiviral effects of ganciclovir.

Authors:  F M Hamzeh; T Spector; P S Lietman
Journal:  Antimicrob Agents Chemother       Date:  1993-03       Impact factor: 5.191

Review 6.  Aciclovir. A reappraisal of its antiviral activity, pharmacokinetic properties and therapeutic efficacy.

Authors:  A J Wagstaff; D Faulds; K L Goa
Journal:  Drugs       Date:  1994-01       Impact factor: 9.546

Review 7.  Acyclovir. An updated review of its antiviral activity, pharmacokinetic properties and therapeutic efficacy.

Authors:  J J O'Brien; D M Campoli-Richards
Journal:  Drugs       Date:  1989-03       Impact factor: 9.546

8.  Specific inhibition of herpes virus replication by receptor-mediated entry of an antiviral peptide linked to Escherichia coli enterotoxin B subunit.

Authors:  A Marcello; A Loregian; A Cross; H Marsden; T R Hirst; G Palù
Journal:  Proc Natl Acad Sci U S A       Date:  1994-09-13       Impact factor: 11.205
  8 in total

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