Literature DB >> 3024561

Comparative methods for detection of thymidine kinase-deficient herpes simplex virus type 1 strains.

J Harmenberg, V A Sundqvist, H Gadler, B Levén, G Brännström, B Wahren.   

Abstract

Four methods for analyzing viral susceptibility to antiviral substances were compared. In two methods viral products were measured: late viral proteins were measured by an enzyme-linked immunosorbent assay and viral DNA was measured by DNA hybridization. Infectious virus was quantified in the other two assays as the number of plaques and the yield of virus. The enzyme-linked immunosorbent assay procedure in our hands detected the smallest amounts (lowest proportions) of thymidine kinase-deficient herpes simplex virus type 1 mixed with wild-type virus. The thymidine kinase-deficient proportion of the herpes simplex virus type 1 isolate increased rapidly in the presence of acyclovir in cell culture.

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Year:  1986        PMID： 3024561      PMCID： PMC176482          DOI： 10.1128/AAC.30.4.570

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  26 in total

1.  Selective assay for herpes simplex viruses expressing thymidine kinase.

Authors:  J Campione-Piccardo; W E Rawls; S Bacchetti
Journal:  J Virol       Date:  1979-08       Impact factor: 5.103

2.  Inhibition of herpes simplex virus infection in tissue culture by trisodium phosphonoformate.

Authors:  B Svennerholm; A Vahlne; E Lycke
Journal:  Proc Soc Exp Biol Med       Date:  1979-06

3.  Spectrum of sensitivity of acyclovir of herpes simplex virus clinical isolates.

Authors:  C McLaren; C D Sibrack; D W Barry
Journal:  Am J Med       Date:  1982-07-20       Impact factor: 4.965

4.  Rapid typing of herpes simplex virus based on immunological specificity of viral thymidine kinase and typing according to sensitivity to iododeoxyuridine.

Authors:  J S Gronowitz; C F Källander; S Jeansson; J Wallin
Journal:  J Clin Microbiol       Date:  1982-03       Impact factor: 5.948

5.  Plaque autoradiography assay for the detection and quantitation of thymidine kinase-deficient and thymidine kinase-altered mutants of herpes simplex virus in clinical isolates.

Authors:  J L Martin; M N Ellis; P M Keller; K K Biron; S N Lehrman; D W Barry; P A Furman
Journal:  Antimicrob Agents Chemother       Date:  1985-08       Impact factor: 5.191

6.  [125I]deoxycytidine used in a rapid, sensitive, and specific assay for herpes simplex virus type 1 thymidine kinase.

Authors:  W C Summers; W P Summers
Journal:  J Virol       Date:  1977-10       Impact factor: 5.103

7.  Herpes simplex virus variants restraint to high concentrations of acyclovir exist in clinical isolates.

Authors:  D S Parris; J E Harrington
Journal:  Antimicrob Agents Chemother       Date:  1982-07       Impact factor: 5.191

8.  Development of clinical resistance to acyclovir in herpes simplex virus-infected mice receiving oral therapy.

Authors:  H J Field
Journal:  Antimicrob Agents Chemother       Date:  1982-05       Impact factor: 5.191

9.  Optimized assay for thymidine kinase and its application to the detection of antibodies against herpes simplex virus type 1- and 2-induced thymidine kinase.

Authors:  J S Gronowitz; C F Källander
Journal:  Infect Immun       Date:  1980-08       Impact factor: 3.441

10.  Influence of cells and virus multiplicity on the inhibition of herpesviruses with acycloguanosine.

Authors:  J Harmenberg; B Wahren; B Oberg
Journal:  Intervirology       Date:  1980       Impact factor: 1.763
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  6 in total

1.  Antiviral susceptibility testing with a cell line which expresses beta-galactosidase after infection with herpes simplex virus.

Authors:  P Tebas; E C Stabell; P D Olivo
Journal:  Antimicrob Agents Chemother       Date:  1995-06       Impact factor: 5.191

2.  Effects of ribonucleotide reductase inhibition on pyrimidine deoxynucleotide metabolism in acyclovir-treated cells infected with herpes simplex virus type 1.

Authors:  A Karlsson; J Harmenberg
Journal:  Antimicrob Agents Chemother       Date:  1988-07       Impact factor: 5.191

3.  Antiviral activities of guanosine analogs in guinea pig embryonic fibroblasts.

Authors:  J Harmenberg; K Stenberg
Journal:  Antimicrob Agents Chemother       Date:  1988-10       Impact factor: 5.191

4.  Susceptibilities of herpes simplex viruses to penciclovir and acyclovir in eight cell lines.

Authors:  Jeffry J Leary; Robert Wittrock; Robert T Sarisky; Adriana Weinberg; Myron J Levin
Journal:  Antimicrob Agents Chemother       Date:  2002-03       Impact factor: 5.191

5.  Orofacial infection of athymic mice with defined mixtures of acyclovir-susceptible and acyclovir-resistant herpes simplex virus type 1.

Authors:  M N Ellis; R Waters; E L Hill; D C Lobe; D W Selleseth; D W Barry
Journal:  Antimicrob Agents Chemother       Date:  1989-03       Impact factor: 5.191

Review 6.  Persistent herpes simplex virus infection and mechanisms of virus drug resistance.

Authors:  H J Field
Journal:  Eur J Clin Microbiol Infect Dis       Date:  1989-08       Impact factor: 3.267
  6 in total

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