Literature DB >> 6302590

Inhibition of GABA and benzodiazepine receptor binding by penicillins.

A Antoniadis, W E Müller, U Wollert.   

Abstract

Penicillins are thought to be GABA receptor antagonists. In order to determine the affinities of various penicillin derivatives for the GABA receptor, their potencies as inhibitors of specific [3H]GABA binding to rat brain membranes were investigated. All investigated penicillins inhibit specific [3H]GABA binding, with IC50 values ranging from 2 to 60 mM. The results are consistent with the assumption that penicillins are weak GABA receptor antagonists.

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Year:  1980        PMID： 6302590     DOI： 10.1016/0304-3940(80)90302-x

Source DB:  PubMed          Journal:  Neurosci Lett        ISSN： 0304-3940            Impact factor:   3.046


  12 in total

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