Literature DB >> 30557621

The paroxysmal depolarization shift in epilepsy research.

Matej Hotka1, Helmut Kubista2.   

Abstract

Several shortcomings with currently available pharmacotherapy of epilepsy necessitate the search for new drug targets. Paroxysmal depolarization shifts (PDS) represent the cellular correlates of electrographic (e.g. interictal) spikes. While the ionic basis of PDS is understood in great detail, controversy exists regarding their proposed implication in epilepsy. To address this issue and to consider potential targetability, this mini-review gives an overview of the ionic conductances contributing to PDS and reflects on the hypotheses of their potential pro-epileptic (epileptogenic) and anti-epileptic roles.
Copyright © 2018 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  Epileptogenesis; Hippocampal neurons; Interictal spike; L-type voltage-gated calcium channels

Mesh：

Year:  2018        PMID： 30557621      PMCID： PMC7116775          DOI： 10.1016/j.biocel.2018.12.006

Source DB:  PubMed          Journal:  Int J Biochem Cell Biol        ISSN： 1357-2725            Impact factor:   5.085


  33 in total

1.  Muscarinic depression of synaptic transmission in the epileptogenic GABA withdrawal syndrome focus.

Authors:  C Silva-Barrat; M Szente; C Menini; J C Velluti; J Champagnat
Journal:  J Neurophysiol       Date:  2001-05       Impact factor: 2.714

2.  Inter-ictal- and ictal-like epileptic discharges in the dendritic tree of neocortical pyramidal neurons.

Authors:  Yitzhak Schiller
Journal:  J Neurophysiol       Date:  2002-12       Impact factor: 2.714

Review 3.  Interictal spikes in focal epileptogenesis.

Authors:  M de Curtis; G Avanzini
Journal:  Prog Neurobiol       Date:  2001-04       Impact factor: 11.685

4.  The depolarization shift in "epileptic" neurons.

Authors:  D A Prince
Journal:  Exp Neurol       Date:  1968-08       Impact factor: 5.330

5.  Differential antiepileptic effects of the organic calcium antagonists verapamil and flunarizine in neurons of organotypic neocortical explants from newborn rats.

Authors:  D Bingmann; E J Speckmann; R E Baker; J Ruijter; B M de Jong
Journal:  Exp Brain Res       Date:  1988       Impact factor: 1.972

6.  Effect of interictal spikes on single-cell firing patterns in the hippocampus.

Authors:  Jun-Li Zhou; Pierre-Pascal Lenck-Santini; Qian Zhao; Gregory L Holmes
Journal:  Epilepsia       Date:  2007-02-05       Impact factor: 5.864

7.  Epileptiform activity in microcultures containing small numbers of hippocampal neurons.

Authors:  M M Segal; E J Furshpan
Journal:  J Neurophysiol       Date:  1990-11       Impact factor: 2.714

8.  Calcium-dependent mitochondrial superoxide modulates nuclear CREB phosphorylation in hippocampal neurons.

Authors:  Jarin Hongpaisan; Christine A Winters; S Brian Andrews
Journal:  Mol Cell Neurosci       Date:  2003-12       Impact factor: 4.314

9.  Inhibition of GABA and benzodiazepine receptor binding by penicillins.

Authors:  A Antoniadis; W E Müller; U Wollert
Journal:  Neurosci Lett       Date:  1980-07       Impact factor: 3.046

10.  Spreading convulsions, spreading depolarization and epileptogenesis in human cerebral cortex.

Authors:  Jens P Dreier; Sebastian Major; Heinz-Wolfgang Pannek; Johannes Woitzik; Michael Scheel; Dirk Wiesenthal; Peter Martus; Maren K L Winkler; Jed A Hartings; Martin Fabricius; Erwin-Josef Speckmann; Ali Gorji
Journal:  Brain       Date:  2011-11-26       Impact factor: 13.501
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  5 in total

1.  Role of paroxysmal depolarization in focal seizure activity.

Authors:  Andrew K Tryba; Edward M Merricks; Somin Lee; Tuan Pham; SungJun Cho; Douglas R Nordli; Tahra L Eissa; Robert R Goodman; Guy M McKhann; Ronald G Emerson; Catherine A Schevon; Wim van Drongelen
Journal:  J Neurophysiol       Date:  2019-08-28       Impact factor: 2.714

2.  Inhibition of Transient Receptor Potential Vanilloid 4 (TRPV4) Mitigates Seizures.

Authors:  Meng-Liu Zeng; Jing-Jing Cheng; Shuo Kong; Xing-Liang Yang; Xiang-Lei Jia; Xue-Lei Cheng; Ling Chen; Fang-Gang He; Yu-Min Liu; Yuan-Teng Fan; Lanzi Gongga; Tao-Xiang Chen; Wan-Hong Liu; Xiao-Hua He; Bi-Wen Peng
Journal:  Neurotherapeutics       Date:  2022-02-18       Impact factor: 6.088

Review 3.  The Paroxysmal Depolarization Shift: Reconsidering Its Role in Epilepsy, Epileptogenesis and Beyond.

Authors:  Helmut Kubista; Stefan Boehm; Matej Hotka
Journal:  Int J Mol Sci       Date:  2019-01-29       Impact factor: 5.923

4.  What Triggers the Interictal Epileptic Spike? A Multimodal Multiscale Analysis of the Dynamic of Synaptic and Non-synaptic Neuronal and Vascular Compartments Using Electrical and Optical Measurements.

Authors:  Cristian Arnal-Real; Mahdi Mahmoudzadeh; Mana Manoochehri; Mina Nourhashemi; Fabrice Wallois
Journal:  Front Neurol       Date:  2021-02-12       Impact factor: 4.003

5.  Synaptic hyperexcitability of cytomegalic pyramidal neurons contributes to epileptogenesis in tuberous sclerosis complex.

Authors:  Xiaoping Wu; Alexander A Sosunov; Wudu Lado; Jia Jie Teoh; Ahrom Ham; Hongyu Li; Osama Al-Dalahmah; Brian J A Gill; Ottavio Arancio; Catherine A Schevon; Wayne N Frankel; Guy M McKhann; David Sulzer; James E Goldman; Guomei Tang
Journal:  Cell Rep       Date:  2022-07-19       Impact factor: 9.995
  5 in total

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