Literature DB >> 2988433

Inhibitory effect of cephalosporins on gamma-aminobutyric acid receptor binding in rat synaptic membranes.

S Hori, S Kurioka, M Matsuda, J Shimada.   

Abstract

Cephalosporins inhibited gamma-aminobutyric acid receptor binding in a concentration-dependent manner in vitro. Scatchard analysis revealed that cefazolin decreased the binding capacity but did not change the affinity of the receptor. It is suggested that this inhibition of gamma-aminobutyric acid receptor binding may be involved in the induction of convulsions by cephalosporins.

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Year:  1985        PMID： 2988433      PMCID： PMC180115          DOI： 10.1128/AAC.27.4.650

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  17 in total

1.  Protein measurement with the Folin phenol reagent.

Authors:  O H LOWRY; N J ROSEBROUGH; A L FARR; R J RANDALL
Journal:  J Biol Chem       Date:  1951-11       Impact factor: 5.157

2.  Properties of gamma-aminobutyric acid (GABA) receptor binding in rat brain synaptic membrane fractions.

Authors:  S J Enna; S H Snyder
Journal:  Brain Res       Date:  1975-12-12       Impact factor: 3.252

3.  Convulsive action of penicillin.

Authors:  D R Curtis; C J Game; G A Johnston; R M McCulloch; R M MacLachlan
Journal:  Brain Res       Date:  1972-08-11       Impact factor: 3.252

4.  Effect of penicillin on transmitter release from rat cortical tissue.

Authors:  T de Boer; J C Stoof; H van Duyn
Journal:  Brain Res       Date:  1980-06-16       Impact factor: 3.252

5.  Effects of drugs on gamma-aminobutyric acid receptors, uptake, release and synthesis in vitro.

Authors:  R W Olsen; M K Ticku; P C Van Ness; D Greenlee
Journal:  Brain Res       Date:  1978-01-13       Impact factor: 3.252

6.  Convulsions associated with sodium cefazolin: a case report.

Authors:  R L Yost; J D Lee; J P O'Leary
Journal:  Am Surg       Date:  1977-06       Impact factor: 0.688

7.  Convulsion following intrathecal cephaloridine.

Authors:  H Yoshioka; H Nambu; M Fujita; H Uehara
Journal:  Infection       Date:  1975       Impact factor: 3.553

8.  Behavioral and electrocortical effects after intrastriatal cefazolin in rats are antagonized by drugs enhancing GABA-ergic transmission.

Authors:  G Nistico; G B De Sarro; D Rotiroti; F Naccari; M Calo; R Silvestri; N Pisanti
Journal:  Res Commun Chem Pathol Pharmacol       Date:  1980-09

9.  Seizures associated with high cerebrospinal fluid concentrations of cefazolin.

Authors:  T P Bechtel; R L Slaughter; T D Moore
Journal:  Am J Hosp Pharm       Date:  1980-02

10.  GABA depletion in chick brain-stem after intraventricular injection of cefazolin.

Authors:  R Ientile; R M Di Giorgio; D Rotiroti; G Nistico'
Journal:  Res Commun Chem Pathol Pharmacol       Date:  1981-02
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  10 in total

Review 1.  Quinolone antimicrobial agents: adverse effects and bacterial resistance.

Authors:  J S Wolfson
Journal:  Eur J Clin Microbiol Infect Dis       Date:  1989-12       Impact factor: 3.267

2.  Animal model for evaluating the convulsive liability of beta-lactam antibiotics.

Authors:  P D Williams; D B Bennett; C R Comereski
Journal:  Antimicrob Agents Chemother       Date:  1988-05       Impact factor: 5.191

3.  The beta-lactam antibiotics, penicillin-G and cefoselis have different mechanisms and sites of action at GABA(A) receptors.

Authors:  Masahiro Sugimoto; Sakae Fukami; Hiroshi Kayakiri; Shunji Yamazaki; Nobuya Matsuoka; Ichiro Uchida; Takashi Mashimo
Journal:  Br J Pharmacol       Date:  2002-01       Impact factor: 8.739

Review 4.  Neurotoxicity induced by beta-lactam antibiotics: from bench to bedside.

Authors:  K M Chow; A C Hui; C C Szeto
Journal:  Eur J Clin Microbiol Infect Dis       Date:  2005-10       Impact factor: 3.267

5.  Relationship between structure and convulsant properties of some beta-lactam antibiotics following intracerebroventricular microinjection in rats.

Authors:  A De Sarro; D Ammendola; M Zappala; S Grasso; G B De Sarro
Journal:  Antimicrob Agents Chemother       Date:  1995-01       Impact factor: 5.191

6.  Quinolones potentiate cefazolin-induced seizures in DBA/2 mice.

Authors:  A De Sarro; M Zappalá; A Chimirri; S Grasso; G B De Sarro
Journal:  Antimicrob Agents Chemother       Date:  1993-07       Impact factor: 5.191

7.  Low neurotoxicity of LJC 10,627, a novel 1 beta-methyl carbapenem antibiotic: inhibition of gamma-aminobutyric acidA, benzodiazepine, and glycine receptor binding in relation to lack of central nervous system toxicity in rats.

Authors:  M Hikida; Y Masukawa; K Nishiki; N Inomata
Journal:  Antimicrob Agents Chemother       Date:  1993-02       Impact factor: 5.191

8.  Possible intermolecular interaction between quinolones and biphenylacetic acid inhibits gamma-aminobutyric acid receptor sites.

Authors:  K Akahane; Y Kimura; Y Tsutomi; I Hayakawa
Journal:  Antimicrob Agents Chemother       Date:  1994-10       Impact factor: 5.191

9.  Effect of experimental renal failure and hypotonic hyponatremia on the pharmacodynamics of cefazolin-induced seizures in rats.

Authors:  Masashi Nagata; Takuya Fujichika; Masato Yasuhara
Journal:  Pharm Res       Date:  2003-06       Impact factor: 4.200

10.  Inhibitory effects of quinolone antibacterial agents on gamma-aminobutyric acid binding to receptor sites in rat brain membranes.

Authors:  A Tsuji; H Sato; Y Kume; I Tamai; E Okezaki; O Nagata; H Kato
Journal:  Antimicrob Agents Chemother       Date:  1988-02       Impact factor: 5.191
  10 in total

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