Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 The murine Ia alpha chains, E alpha and A alpha, show a surprising degree of sequence homology.

Literature DB >> 6300851

The murine Ia alpha chains, E alpha and A alpha, show a surprising degree of sequence homology.

C O Benoist, D J Mathis, M R Kanter, V E Williams, H O McDevitt.

Abstract

The I region of the murine major histocompatibility complex codes for a group of glycoproteins, the Ia antigens, thought to be involved in the control of immune responsiveness. Each Ia antigen complex contains a "heavy chain," a "light chain," and the "invariant chain." We describe here the isolation and characterization of genomic and cDNA clones for one of the heavy chains, Ak alpha. The complete nucleotide sequence of the cDNA clone is presented, and the predicted amino acid sequence is compared with that of another alpha chain, Ek alpha. About 50% of the amino acids are identical, a finding somewhat unexpected on the basis of preliminary protein sequence data.

Entities: Gene Species

Mesh：

Substances：

Year: 1983 PMID： 6300851 PMCID： PMC393413 DOI： 10.1073/pnas.80.2.534

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

18 in total

1. Analysis of transcription of the human Alu family ubiquitous repeating element by eukaryotic RNA polymerase III.

Authors: S A Fuhrman; P L Deininger; P LaPorte; T Friedmann; E P Geiduschek
Journal: Nucleic Acids Res Date: 1981-12-11 Impact factor: 16.971

2. Structure of C-terminal half of two H-2 antigens from cloned mRNA.

Authors: F Brégégère; J P Abastado; S Kvist; L Rask; J L Lalanne; H Garoff; B Cami; K Wiman; D Larhammar; P A Peterson; G Gachelin; P Kourilsky; B Dobberstein
Journal: Nature Date: 1981-07-02 Impact factor: 49.962

Review 3. The role of H-2 I region genes in regulation of the immune response.

Authors: H O McDevitt
Journal: J Immunogenet Date: 1981-08

4. DNA sequence of a gene encoding a BALB/c mouse Ld transplantation antigen.

Authors: K W Moore; B T Sher; Y H Sun; K A Eakle; L Hood
Journal: Science Date: 1982-02-05 Impact factor: 47.728

5. Isolation of high-molecular-weight DNA from mammalian cells.

Authors: M Gross-Bellard; P Oudet; P Chambon
Journal: Eur J Biochem Date: 1973-07-02

6. A shared alloantigenic determinant on Ia antigens encoded by the I-A and I-E subregions: evidence for I region gene duplication.

Authors: A Bhattacharya; M E Dorf; T A Springer
Journal: J Immunol Date: 1981-12 Impact factor: 5.422

7. Isolation of a cDNA clone for the human HLA-DR antigen alpha chain by using a synthetic oligonucleotide as a hybridization probe.

Authors: D Stetler; H Das; J H Nunberg; R Saiki; R Sheng-Dong; K B Mullis; S M Weissman; H A Erlich
Journal: Proc Natl Acad Sci U S A Date: 1982-10 Impact factor: 11.205

8. Alpha chain of HLA-DR transplantation antigens is a member of the same protein superfamily as the immunoglobulins.

Authors: D Larhammar; K Gustafsson; L Claesson; P Bill; K Wiman; L Schenning; J Sundelin; E Widmark; P A Peterson; L Rask
Journal: Cell Date: 1982-08 Impact factor: 41.582

Review 9. Sugar residues on proteins.

Authors: P V Wagh; O P Bahl
Journal: CRC Crit Rev Biochem Date: 1981

10. A pseudogene homologous to mouse transplantation antigens: transplantation antigens are encoded by eight exons that correlate with protein domains.

Authors: M Steinmetz; K W Moore; J G Frelinger; B T Sher; F W Shen; E A Boyse; L Hood
Journal: Cell Date: 1981-09 Impact factor: 41.582

43 in total

1. Allorecognition of DR1 by T cells from a DR4/DRw13 responder mimics self-restricted recognition of endogenous peptides.

Authors: G Lombardi; S Sidhu; J R Batchelor; R I Lechler
Journal: Proc Natl Acad Sci U S A Date: 1989-06 Impact factor: 11.205

The murine Ia alpha chains, E alpha and A alpha, show a surprising degree of sequence homology.

1. Analysis of transcription of the human Alu family ubiquitous repeating element by eukaryotic RNA polymerase III.

2. Structure of C-terminal half of two H-2 antigens from cloned mRNA.

Review 3. The role of H-2 I region genes in regulation of the immune response.

4. DNA sequence of a gene encoding a BALB/c mouse Ld transplantation antigen.

5. Isolation of high-molecular-weight DNA from mammalian cells.

6. A shared alloantigenic determinant on Ia antigens encoded by the I-A and I-E subregions: evidence for I region gene duplication.

7. Isolation of a cDNA clone for the human HLA-DR antigen alpha chain by using a synthetic oligonucleotide as a hybridization probe.

8. Alpha chain of HLA-DR transplantation antigens is a member of the same protein superfamily as the immunoglobulins.

Review 9. Sugar residues on proteins.

10. A pseudogene homologous to mouse transplantation antigens: transplantation antigens are encoded by eight exons that correlate with protein domains.

1. Allorecognition of DR1 by T cells from a DR4/DRw13 responder mimics self-restricted recognition of endogenous peptides.

2. DNase I hypersensitive sites flank the mouse class II major histocompatibility complex during B cell development.

3. Structure function analysis of the H-2 Abp gene.

4. A molecular basis for the Ia.2 and Ia.19 antigenic determinants.

5. Sequence analysis and structure-function correlations of murine q, k, u, s, and f haplotype I-A beta cDNA clones.

6. Polymorphism and mapping of the class II genes in the rat: RT1.B, RT1.D, and RT1.H, a new DP-like region.

7. DNA sequence analysis of a rat RT1 class II A beta gene.

8. Actively transcribed genes in the raf oncogene group, located on the X chromosome in mouse and human.

9. Several mechanisms can account for defective E alpha gene expression in different mouse haplotypes.

10. Isolation and characterization of major histocompatibility complex class IIB genes from the nurse shark.