Literature DB >> 6299796

Cellular localization of the receptor-dependent and receptor-independent uptake of human LDL in the liver of normal and 17 alpha-ethinyl estradiol-treated rats.

L Harkes, T J van Berkel.   

Abstract

The cellular localization in the liver of the receptor-dependent and -independent uptake of human low density lipoprotein (LDL) in normal and 17 alpha-ethinyl estradiol-treated rats was investigated by the simultaneous in vivo injection of human 131I-LDL and human reductive methylated 125I-LDL. The cells were subsequently isolated by a low temperature method. In untreated rats, after 30 min of in vivo circulation of human LDL, 57% of the receptor-dependent liver-association of human LDL occurs in non-parenchymal cells and 43% in parenchymal cells. Estradiol treatment of rats for 3 days selectively increases the receptor-dependent cell-association of human LDL with hepatocytes (17-fold), while the receptor-dependent cell-association with non-parenchymal cells is not affected.

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Year:  1983        PMID： 6299796     DOI： 10.1016/0014-5793(83)80878-3

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  7 in total

1.  Recognition of chylomicron remnants and beta-migrating very-low-density lipoproteins by the remnant receptor of parenchymal liver cells is distinct from the liver alpha 2-macroglobulin-recognition site.

Authors:  M C van Dijk; G J Ziere; W Boers; C Linthorst; M K Bijsterbosch; T J van Berkel
Journal:  Biochem J       Date:  1991-11-01       Impact factor: 3.857

2.  Evidence for reverse cholesterol transport in vivo from liver endothelial cells to parenchymal cells and bile by high-density lipoprotein.

Authors:  H F Bakkeren; F Kuipers; R J Vonk; T J Van Berkel
Journal:  Biochem J       Date:  1990-06-15       Impact factor: 3.857

3.  Quantitative role of parenchymal and non-parenchymal liver cells in the uptake of [14C]sucrose-labelled low-density lipoprotein in vivo.

Authors:  L Harkes; J C Van Berkel
Journal:  Biochem J       Date:  1984-11-15       Impact factor: 3.857

4.  Uptake and catabolism of modified LDL in scavenger-receptor class A type I/II knock-out mice.

Authors:  T J Van Berkel; A Van Velzen; J K Kruijt; H Suzuki; T Kodama
Journal:  Biochem J       Date:  1998-04-01       Impact factor: 3.857

5.  Processing of cholesteryl ester from low-density lipoproteins in the rat. Hepatic metabolism and biliary secretion after uptake by different hepatic cell types.

Authors:  F Kuipers; J F Nagelkerke; H Bakkeren; R Havinga; T J Van Berkel; R J Vonk
Journal:  Biochem J       Date:  1989-02-01       Impact factor: 3.857

6.  Characterization of the low-density-lipoprotein-receptor-independent interaction of beta-very-low-density lipoprotein with rat and human parenchymal liver cells in vitro.

Authors:  R De Water; J A Kamps; M C Van Dijk; E A Hessels; J Kuiper; J K Kruijt; T J Van Berkel
Journal:  Biochem J       Date:  1992-02-15       Impact factor: 3.857

7.  Selective uptake of cholesteryl esters from apolipoprotein-E-free high-density lipoproteins by rat parenchymal cells in vivo is efficiently coupled to bile acid synthesis.

Authors:  M N Pieters; D Schouten; H F Bakkeren; B Esbach; A Brouwer; D L Knook; T J van Berkel
Journal:  Biochem J       Date:  1991-12-01       Impact factor: 3.857
  7 in total

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