Literature DB >> 6299178

Effects of pH on the activity of ketoconazole against Candida albicans.

H Minagawa, K Kitaura, N Nakamizo.   

Abstract

The activity of ketoconazole against Candida albicans in Sabouraud glucose medium was markedly influenced by pH. Minimum inhibitory concentrations of this imidazole against both a standard strain and clinical isolates ranged from 40 mug/ml at pH 3 to 0.02 mug/ml at pH 7, a greater than 1,000-fold difference.

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Year:  1983        PMID： 6299178      PMCID： PMC184625          DOI： 10.1128/AAC.23.1.105

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  7 in total

1.  Laboratory tests of antifungal drugs.

Authors:  R J Holt
Journal:  J Clin Pathol       Date:  1975-10       Impact factor: 3.411

2.  An evaluation of two years of clinical experience with ketoconazole.

Authors:  J Symoens; M Moens; J Dom; H Scheijgrond; J Dony; V Schuermans; R Legendre; N Finestine
Journal:  Rev Infect Dis       Date:  1980 Jul-Aug

3.  The activity in vitro and in vivo of a new imidazole antifungal, ketoconazole.

Authors:  F C Odds; L J Milne; J C Gentles; E H Ball
Journal:  J Antimicrob Chemother       Date:  1980-01       Impact factor: 5.790

Review 4.  Mechanism of action of antifungal drugs, with special reference to the imidazole derivatives.

Authors:  M Borgers
Journal:  Rev Infect Dis       Date:  1980 Jul-Aug

5.  Antimycotic imidazoles. part 4. Synthesis and antifungal activity of ketoconazole, a new potent orally active broad-spectrum antifungal agent.

Authors:  J Heeres; L J Backx; J H Mostmans; J Van Cutsem
Journal:  J Med Chem       Date:  1979-08       Impact factor: 7.446

6.  Ketoconazole -- a new broad spectrum orally active antimycotic.

Authors:  D Thienpont; J Van Cutsem; F Van Gerven; J Heeres; P A Janssen
Journal:  Experientia       Date:  1979-05-15

7.  Comparison of the in vitro antifungal activities of miconazole and a new imidazole, R41,400.

Authors:  D Dixon; S Shadomy; H J Shadomy; A Espinel-Ingroff; T M Kerkering
Journal:  J Infect Dis       Date:  1978-08       Impact factor: 5.226
  7 in total
  25 in total

1.  Effect of pH on the in vitro activities of amphotericin B, itraconazole, and flucytosine against Aspergillus isolates.

Authors:  D T A Te Dorsthorst; J W Mouton; C J P van den Beukel; H A L van der Lee; J F G M Meis; P E Verweij
Journal:  Antimicrob Agents Chemother       Date:  2004-08       Impact factor: 5.191

2.  Protonation of ketoconazole in relation to fungistatic activity.

Authors:  W H Beggs
Journal:  Mycopathologia       Date:  1991-10       Impact factor: 2.574

3.  Improved method for azole antifungal susceptibility testing.

Authors:  M A Gordon; E W Lapa; P G Passero
Journal:  J Clin Microbiol       Date:  1988-09       Impact factor: 5.948

4.  Analysis of growth characteristics of filamentous fungi in different nutrient media.

Authors:  J Meletiadis; J F Meis; J W Mouton; P E Verweij
Journal:  J Clin Microbiol       Date:  2001-02       Impact factor: 5.948

5.  Susceptibility of Torulopsis glabrata in the presence of six antifungal agents determined by comparison of growth at several pHs.

Authors:  J C Darbord; F Vincent; L Boutron; V Goury; S Guyomard
Journal:  Appl Environ Microbiol       Date:  1987-03       Impact factor: 4.792

6.  Direct membrane-damaging effect of ketoconazole and tioconazole on Candida albicans demonstrated by bioluminescent assay of ATP.

Authors:  S Anséhn; L Nilsson
Journal:  Antimicrob Agents Chemother       Date:  1984-07       Impact factor: 5.191

7.  Broth dilution testing of Candida albicans susceptibility to ketoconazole.

Authors:  C E Hughes; R L Bennett; W H Beggs
Journal:  Antimicrob Agents Chemother       Date:  1987-04       Impact factor: 5.191

8.  In vitro susceptibilities of yeasts to a new antifungal triazole, SCH 39304: effects of test conditions and relation to in vivo efficacy.

Authors:  K A McIntyre; J N Galgiani
Journal:  Antimicrob Agents Chemother       Date:  1989-07       Impact factor: 5.191

9.  Effect of the antimycotic drug naftifine on growth of and sterol biosynthesis in Candida albicans.

Authors:  N S Ryder; G Seidl; P F Troke
Journal:  Antimicrob Agents Chemother       Date:  1984-04       Impact factor: 5.191

10.  Effect of medium composition on results of macrobroth dilution antifungal susceptibility testing of yeasts.

Authors:  G V Doern; T A Tubert; K Chapin; M G Rinaldi
Journal:  J Clin Microbiol       Date:  1986-10       Impact factor: 5.948
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