Literature DB >> 6292457

Hypomethylation of Epstein-Barr virus DNA in the nonproducer B-cell line EBR.

D Larocca, W Clough.   

Abstract

The conversion of the Epstein-Barr virus-negative Ramos cell line has previously been shown to result in an Epstein-Barr virus-positive non-virus-producer cell line, EBR. We report here that Epstein-Barr virus DNA from EBR alone among several cell lines examined was totally unmethylated at three of four sites containing guanine plus cytosine which were tested. This is in direct contrast to reports of high degrees of methylation in the DNAs of other animal viruses, including herpesviruses, isolated from cells in which the viral genome is expressed at a low level.

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Year:  1982        PMID： 6292457      PMCID： PMC256226     

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  26 in total

1.  Establishment of EBNA-expressing cell lines by infection of Epstein-Barr virus (EBV)-genome-negative human lymphoma cells with different EBV strains.

Authors:  K O Fresen; H Hausen
Journal:  Int J Cancer       Date:  1976-02-15       Impact factor: 7.396

2.  Detection of specific sequences among DNA fragments separated by gel electrophoresis.

Authors:  E M Southern
Journal:  J Mol Biol       Date:  1975-11-05       Impact factor: 5.469

3.  A general method for isolation of high molecular weight DNA from eukaryotes.

Authors:  N Blin; D W Stafford
Journal:  Nucleic Acids Res       Date:  1976-09       Impact factor: 16.971

4.  Labeling deoxyribonucleic acid to high specific activity in vitro by nick translation with DNA polymerase I.

Authors:  P W Rigby; M Dieckmann; C Rhodes; P Berg
Journal:  J Mol Biol       Date:  1977-06-15       Impact factor: 5.469

5.  Epstein-Barr virus: transformation, cytopathic changes, and viral antigens in squirrel monkey and marmoset leukocytes.

Authors:  G Miller; T Shope; H Lisco; D Stitt; M Lipman
Journal:  Proc Natl Acad Sci U S A       Date:  1972-02       Impact factor: 11.205

6.  Rare bases in animal DNA.

Authors:  B F Vanyushin; S G Tkacheva; A N Belozersky
Journal:  Nature       Date:  1970-03-07       Impact factor: 49.962

7.  Molecular weight estimation and separation of ribonucleic acid by electrophoresis in agarose-acrylamide composite gels.

Authors:  A C Peacock; C W Dingman
Journal:  Biochemistry       Date:  1968-02       Impact factor: 3.162

8.  Use of restriction enzymes to study eukaryotic DNA methylation: I. The methylation pattern in ribosomal DNA from Xenopus laevis.

Authors:  A P Bird; E M Southern
Journal:  J Mol Biol       Date:  1978-01-05       Impact factor: 5.469

9.  Specificity of Hpa II and Hae III DNA methylases.

Authors:  M B Mann; H O Smith
Journal:  Nucleic Acids Res       Date:  1977-12       Impact factor: 16.971

10.  DNA methylation in adenovirus, adenovirus-transformed cells, and host cells.

Authors:  U Gunthert; M Schweiger; M Stupp; W Doerfler
Journal:  Proc Natl Acad Sci U S A       Date:  1976-11       Impact factor: 11.205
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  2 in total

1.  Cellular and viral DNA hypomethylation associated with induction of Epstein-Barr virus lytic cycle.

Authors:  M Szyf; L Eliasson; V Mann; G Klein; A Razin
Journal:  Proc Natl Acad Sci U S A       Date:  1985-12       Impact factor: 11.205

2.  Primary structure of the herpesvirus saimiri genome.

Authors:  J C Albrecht; J Nicholas; D Biller; K R Cameron; B Biesinger; C Newman; S Wittmann; M A Craxton; H Coleman; B Fleckenstein
Journal:  J Virol       Date:  1992-08       Impact factor: 5.103
  2 in total

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