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Literature DB >> 6290904

Noradrenaline inhibits central serotonin release through alpha 2-adrenoceptors located on serotonergic nerve terminals.

Abstract

The effect of noradrenaline on the depolarization-evoked release of 3H-5-hydroxytryptamine was investigated in superfused synaptosomes prepared from rat cortex and hippocampus and prelabelled with the radioactive indoleamine. Noradrenaline reduced in a concentration-dependent way the release of 3H-5-hydroxytryptamine elicited by 15 mM KCl. The inhibition was counteracted by the alpha-adrenoceptor antagonists phentolamine or yohimbine, but not by prazosin. The results indicate that, in rat brain, the inhibition of 5-hydroxytryptamine release by noradrenaline is mediated by adrenoceptors of the alpha 2-type localized on the terminal serotonergic fibres.

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Year: 1982 PMID： 6290904 DOI： 10.1007/bf00510140

Source DB: PubMed Journal: Naunyn Schmiedebergs Arch Pharmacol ISSN： 0028-1298 Impact factor: 3.000

10 in total

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19 in total

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Authors: Carl D Smith; M Allie Holschbach; Joshua Olsewicz; Joseph S Lonstein
Journal: Psychopharmacology (Berl) Date: 2012-05-29 Impact factor: 4.530

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