Literature DB >> 6247164

Noradrenaline inhibits depolarization-induced 3H-serotonin release from slices of rat hippocampus.

A L Frankhuyzen, A H Mulder.   

Abstract

The depolarization (26 mM K+)-induced release of 3H-serotonin and 3H-noradrenaline from slices of rat hippocampus was studied with a superfusion method. Exogenous NA (in the presence of 10 muM desipramine) inhibited 3H-5-HT release (EC50 3 X 10(-7) M) as well as 3H-NA release (EC50 10(-7) M) by more than 70%. Both of these effects were competitively antagonized by phentolamine, but not by propranolol. It is tentatively suggested that the inhibitory effect of NA on 3H-5-HT release from hippocampus slices reflects the activation of postsynaptic alpha-receptors which are localized on serotonergic nerve terminals.

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Year:  1980        PMID： 6247164     DOI： 10.1016/0014-2999(80)90441-0

Source DB:  PubMed          Journal:  Eur J Pharmacol        ISSN： 0014-2999            Impact factor:   4.432


  27 in total

1.  Phentolamine blocks presynaptic serotonin autoreceptors in rabbit and rat brain cortex.

Authors:  N Limberger; M R Fischer; T Wichmann; K Starke
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1989-07       Impact factor: 3.000

2.  Effects of alpha-adrenoceptor antagonists on the release of serotonin and noradrenaline from rat brain cortex slices. Influence of noradrenaline uptake inhibition and determination of pA2 values.

Authors:  E Schlicker; M Göthert; F Köstermann; R Clausing
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1983-06       Impact factor: 3.000

3.  Relationship between transmitter uptake inhibition and effects of alpha-adrenoceptor agonists on serotonin and noradrenaline release in the rat brain cortex.

Authors:  M Göthert; E Schlicker; F Köstermann
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1983-03       Impact factor: 3.000

4.  Modulation of the hypothermic and hyperglycaemic effects of 8-OH-DPAT by alpha 2-adrenoceptor antagonists.

Authors:  M J Durcan; K M Wozniak; M Linnoila
Journal:  Br J Pharmacol       Date:  1991-01       Impact factor: 8.739

5.  Cyanopindolol is a highly potent and selective antagonist at the presynaptic serotonin autoreceptor in the rat brain cortex.

Authors:  E Schlicker; M Göthert; K Hillenbrand
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1985-12       Impact factor: 3.000

6.  Characterization of the receptor subtype involved in alpha-adrenoceptor-mediated modulation of serotonin release from rat brain cortex slices.

Authors:  M Göthert; H Huth; E Schlicker
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1981-11       Impact factor: 3.000

7.  Effects of DSP-4 on monoamine and monoamine metabolite levels and on beta adrenoceptor binding kinetics in rat brain at different times after administration.

Authors:  C N Theron; A S de Villiers; J J Taljaard
Journal:  Neurochem Res       Date:  1993-12       Impact factor: 3.996

8.  Noradrenaline inhibits central serotonin release through alpha 2-adrenoceptors located on serotonergic nerve terminals.

Authors:  G Maura; A Gemignani; M Raiteri
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1982-09       Impact factor: 3.000

9.  Selective alteration of neurotransmitter release by low oxygen in vitro.

Authors:  J A Hirsch; G E Gibson
Journal:  Neurochem Res       Date:  1984-08       Impact factor: 3.996

10.  The profiles of interaction of yohimbine with anxiolytic and putative anxiolytic agents to modify 5-HT release in the frontal cortex of freely-moving rats.

Authors:  C H Cheng; B Costall; J Ge; R J Naylor
Journal:  Br J Pharmacol       Date:  1993-11       Impact factor: 8.739
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