Literature DB >> 629046

Genetic polymorphism of the fourth component of human complement.

G Mauff, K Bender, B Fischer.   

Abstract

A modified electrophoretic system for the determination of C4 polymorphism has been found with which the new allotype F1 could be detected. The system has been applied to the population distribution of C4 in 266 unrelated Germans, further to association and linkage studies. Gene frequency was 0.3985 for C4F, 0.5526 for C4S and 0.0489 for the rare C4 genes. In the population sample, significant association between Bf and C4 but no indication for close association between C4 and GLO I has been found. In the families HLA, Bf and C4 segregated together.

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Year:  1978        PMID： 629046     DOI： 10.1111/j.1423-0410.1978.tb02485.x

Source DB:  PubMed          Journal:  Vox Sang        ISSN： 0042-9007            Impact factor:   2.144


  10 in total

1.  Two HLA-linked loci controlling the fourth component of human complement.

Authors:  G J O'Neill; S Y Yang; B Dupont
Journal:  Proc Natl Acad Sci U S A       Date:  1978-10       Impact factor: 11.205

2.  The C4 system: formal and population genetics.

Authors:  B Olaisen; P Teisberg; R Jonassen; T Gedde-Dahl
Journal:  Hum Genet       Date:  1979       Impact factor: 4.132

3.  Genetic studies of complement C4 in man.

Authors:  G B Petersen; I J Sørensen; L Buskjaer; L U Lamm
Journal:  Hum Genet       Date:  1979       Impact factor: 4.132

4.  Clinical applications of immunofixation: detection and quantitation of complement activation.

Authors:  J T Whicher; J Higginson; P G Riches; S Radford
Journal:  J Clin Pathol       Date:  1980-08       Impact factor: 3.411

5.  Analysis of active and inactive complement C4 complotypes associated with subtypes of HLA-B17 in different racial groups.

Authors:  G J O'Neill; C Nerl; M S Pollack
Journal:  Am J Hum Genet       Date:  1983-03       Impact factor: 11.025

Review 6.  On the significance of C2, C4, and factor B polymorphisms in disease.

Authors:  C Rittner; J Bertrams
Journal:  Hum Genet       Date:  1981       Impact factor: 4.132

7.  Family studies of complement C4 and HLA in man.

Authors:  G Bruun-Petersen; L U Lamm; I J Sørensen; L Buskjaer; J P Mortensen
Journal:  Hum Genet       Date:  1981       Impact factor: 4.132

8.  Human C4 polymorphism: pedigree analysis of qualitative, quantitative, and functional parameters as a basis for phenotype interpretations.

Authors:  G Mauff; K Bender; C M Giles; S Goldmann; W Opferkuch; B Wachauf
Journal:  Hum Genet       Date:  1984       Impact factor: 4.132

9.  Human C4 haplotypes with duplicated C4A or C4B.

Authors:  D Raum; Z Awdeh; J Anderson; L Strong; J Granados; L Teran; E Giblett; E J Yunis; C A Alper
Journal:  Am J Hum Genet       Date:  1984-01       Impact factor: 11.025

10.  Inherited structural polymorphism of the fourth component of human complement.

Authors:  Z L Awdeh; C A Alper
Journal:  Proc Natl Acad Sci U S A       Date:  1980-06       Impact factor: 11.205
  10 in total

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