Literature DB >> 511133

The C4 system: formal and population genetics.

B Olaisen, P Teisberg, R Jonassen, T Gedde-Dahl.   

Abstract

The present study shows that the C4 system as investigated by high voltage agarose gel electrophoresis is highly polymorphic. In a series of unrelated Norwegian adults, where C4 types have been ascertained through segregation in families, six different haplotypes have been found to occur with a frequency exceeding 1%. The genotype frequencies in the population fit expected Hardy-Weinberg distribution. In family material comprising 89 matings with 327 children the distribution of offspring is as expected according to autosomal codominant inheritance of haplotypes.

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Year:  1979        PMID: 511133     DOI: 10.1007/bf00390240

Source DB:  PubMed          Journal:  Hum Genet        ISSN: 0340-6717            Impact factor:   4.132


  7 in total

1.  Genetic polymorphism of C4 in man and localisation of a structural C4 locus to the HLA gene complex of chromosome 6.

Authors:  P Teisberg; I Akesson; B Olaisen; T Gedde-Dahl; E Thorsby
Journal:  Nature       Date:  1976-11-18       Impact factor: 49.962

2.  Two HLA-linked loci controlling the fourth component of human complement.

Authors:  G J O'Neill; S Y Yang; B Dupont
Journal:  Proc Natl Acad Sci U S A       Date:  1978-10       Impact factor: 11.205

3.  Human complement C4 locus is duplicated on some chromosomes.

Authors:  B Olaisen; P Teisberg; R Nordhagen; T Michaelsen; T Gedde-Dahl
Journal:  Nature       Date:  1979-06-21       Impact factor: 49.962

4.  Structural polymorphism of the fourth component of human complement.

Authors:  S I Rosenfeld; S Ruddy; K F Austen
Journal:  J Clin Invest       Date:  1969-12       Impact factor: 14.808

5.  Inherited polymorphism of guinea pig factor B and C4: evidence for genetic linkage between the C4 and Bf loci.

Authors:  D Bitter-Suermann; M Krönke; V Brade; U Hadding
Journal:  J Immunol       Date:  1977-05       Impact factor: 5.422

6.  Genetic polymorphism of the fourth component of human complement.

Authors:  G Mauff; K Bender; B Fischer
Journal:  Vox Sang       Date:  1978       Impact factor: 2.144

7.  The genetic polymorphism of the fourth component of human complement: methodological aspects and a presentation of linkage and association data relevant to its localization in the HLA region.

Authors:  P Teisberg; B Olaisen; R Jonassen; T Gedde-Dahl; E Thorsby
Journal:  J Exp Med       Date:  1977-11-01       Impact factor: 14.307

  7 in total
  5 in total

1.  Family studies of complement C4 and HLA in man.

Authors:  G Bruun-Petersen; L U Lamm; I J Sørensen; L Buskjaer; J P Mortensen
Journal:  Hum Genet       Date:  1981       Impact factor: 4.132

2.  Genetic polymorphism of the B subunit of human coagulation factor XIII: another classification.

Authors:  Y Kera; H Nishimukai; K Yamasawa
Journal:  Hum Genet       Date:  1981       Impact factor: 4.132

3.  Human C4 polymorphism: pedigree analysis of qualitative, quantitative, and functional parameters as a basis for phenotype interpretations.

Authors:  G Mauff; K Bender; C M Giles; S Goldmann; W Opferkuch; B Wachauf
Journal:  Hum Genet       Date:  1984       Impact factor: 4.132

4.  Human C4 haplotypes with duplicated C4A or C4B.

Authors:  D Raum; Z Awdeh; J Anderson; L Strong; J Granados; L Teran; E Giblett; E J Yunis; C A Alper
Journal:  Am J Hum Genet       Date:  1984-01       Impact factor: 11.025

5.  Inherited structural polymorphism of the fourth component of human complement.

Authors:  Z L Awdeh; C A Alper
Journal:  Proc Natl Acad Sci U S A       Date:  1980-06       Impact factor: 11.205

  5 in total

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