| Literature DB >> 6289440 |
R J Watson, J H Weis, J S Salstrom, L W Enquist.
Abstract
The protein coding region of the herpes simplex virus type-1 glycoprotein D (gD) gene was mapped, and the nucleotide sequence was determined. The predicted amino acid sequence of the gD polypeptide was found to contain a number of features in common with other virus glycoproteins. Insertion of this protein coding region into a bacterial expressor plasmid enabled synthesis in Escherichia coli of an immunoreactive gD-related polypeptide. The potential of this system for preparation of a type-common herpes simplex virus vaccine is discussed.Entities:
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Year: 1982 PMID: 6289440 DOI: 10.1126/science.6289440
Source DB: PubMed Journal: Science ISSN: 0036-8075 Impact factor: 47.728