Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Direct demonstration of genetic alterations at the dihydrofolate reductase locus after gamma irradiation.

Literature DB >> 6287224

Direct demonstration of genetic alterations at the dihydrofolate reductase locus after gamma irradiation.

Abstract

Gamma ray-induced mutants of Chinese hamster ovary cells lacking dihydrofolate reductase activity were screened for DNA sequence changes at the locus specifying this activity by using a cloned cDNA probe. Two of nine mutants screened displayed an altered restriction fragment pattern suggesting the occurrence of DNA deletions or rearrangements.

Entities: CellLine Species

Mesh：

Substances：

Year: 1982 PMID： 6287224 PMCID： PMC369757 DOI： 10.1128/mcb.2.1.93-96.1982

Source DB: PubMed Journal: Mol Cell Biol ISSN： 0270-7306 Impact factor: 4.272

24 in total

1. A complete immunoglobulin gene is created by somatic recombination.

Authors: C Brack; M Hirama; R Lenhard-Schuller; S Tonegawa
Journal: Cell Date: 1978-09 Impact factor: 41.582

2. Re-analysis of radiation-induced specific locus mutations in the mouse.

Authors: S Abrahamson; S Wolff
Journal: Nature Date: 1976 Dec 23-30 Impact factor: 49.962

3. Detection of specific sequences among DNA fragments separated by gel electrophoresis.

Authors: E M Southern
Journal: J Mol Biol Date: 1975-11-05 Impact factor: 5.469

4. The transfer and stable integration of the HSV thymidine kinase gene into mouse cells.

Authors: A Pellicer; M Wigler; R Axel; S Silverstein
Journal: Cell Date: 1978-05 Impact factor: 41.582

5. Labeling deoxyribonucleic acid to high specific activity in vitro by nick translation with DNA polymerase I.

Authors: P W Rigby; M Dieckmann; C Rhodes; P Berg
Journal: J Mol Biol Date: 1977-06-15 Impact factor: 5.469

6. Phenotypic expression in E. coli of a DNA sequence coding for mouse dihydrofolate reductase.

Authors: A C Chang; J H Nunberg; R J Kaufman; H A Erlich; R T Schimke; S N Cohen
Journal: Nature Date: 1978-10-19 Impact factor: 49.962

7. Two different species of dihydrofolate reductase in mammalian cells differentially resistant to amethopterin and methasquin.

Authors: A M Albrecht; J L Biedler; D J Hutchison
Journal: Cancer Res Date: 1972-07 Impact factor: 12.701

8. Do radiation-induced thioguanine-resistant mutants of cultured mammalian cells arise by HGPRT gene mutation or X-chromosome rearrangement?

Authors: R Cox; W K Masson
Journal: Nature Date: 1978-12-07 Impact factor: 49.962

9. Definition of functional units in a small chromosomal segment of the mouse and its use in interpreting the nature of radiation-induced mutations.

Authors: L B Russell
Journal: Mutat Res Date: 1971-01 Impact factor: 2.433

10. Isolation and partial characterization of three methotrexate-resistant phenotypes from Chinese hamster ovary cells.

Authors: W F Flintoff; S V Davidson; L Siminovitch
Journal: Somatic Cell Genet Date: 1976-05

12 in total

1. Base substitutions, frameshifts, and small deletions constitute ionizing radiation-induced point mutations in mammalian cells.

Authors: A J Grosovsky; J G de Boer; P J de Jong; E A Drobetsky; B W Glickman
Journal: Proc Natl Acad Sci U S A Date: 1988-01 Impact factor: 11.205

2. Molecular characterization of 15 rearrangements among 90 human in vivo somatic mutants shows that deletions predominate.

Authors: W E Bradley; J L Gareau; A M Seifert; K Messing
Journal: Mol Cell Biol Date: 1987-02 Impact factor: 4.272

3. Structure of the dihydrofolate reductase gene in Chinese hamster ovary cells.

Authors: A M Carothers; G Urlaub; N Ellis; L A Chasin
Journal: Nucleic Acids Res Date: 1983-04-11 Impact factor: 16.971

4. Locus specificity in the mutability of L5178Y mouse lymphoma cells: the role of multilocus lesions.

Authors: H H Evans; J Mencl; M F Horng; M Ricanati; C Sanchez; J Hozier
Journal: Proc Natl Acad Sci U S A Date: 1986-06 Impact factor: 11.205

5. Native versus recombinant high-mobility group B1 proteins: functional activity in vitro.

Authors: Klaus Zimmermann; Dirk Völkel; Sabrina Pable; Thomas Lindner; Franziska Kramberger; Soheyl Bahrami; Friedrich Scheiflinger
Journal: Inflammation Date: 2004-08 Impact factor: 4.092

6. Characterization of a family of gamma-ray-induced CHO mutants demonstrates that the ldlA locus is diploid and encodes the low-density lipoprotein receptor.

Authors: R D Sege; K F Kozarsky; M Krieger
Journal: Mol Cell Biol Date: 1986-09 Impact factor: 4.272

7. Deletion and amplification of the HGPRT locus in Chinese hamster cells.

Authors: J C Fuscoe; R G Fenwick; D H Ledbetter; C T Caskey
Journal: Mol Cell Biol Date: 1983-06 Impact factor: 4.272

8. Iron (III) citrate inhibits polyethylenimine-mediated transient transfection of Chinese hamster ovary cells in serum-free medium.

Authors: Scott R Eberhardy; Laurie Radzniak; Zhong Liu
Journal: Cytotechnology Date: 2009-06-26 Impact factor: 2.058

9. The Caenorhabditis elegans unc-93 gene encodes a putative transmembrane protein that regulates muscle contraction.

Authors: J Z Levin; H R Horvitz
Journal: J Cell Biol Date: 1992-04 Impact factor: 10.539

Review 10. Ionizing radiation-induced mutagenesis.

Authors: L H Breimer
Journal: Br J Cancer Date: 1988-01 Impact factor: 7.640