Literature DB >> 3821735

Molecular characterization of 15 rearrangements among 90 human in vivo somatic mutants shows that deletions predominate.

W E Bradley, J L Gareau, A M Seifert, K Messing.   

Abstract

Ninety hypoxanthine phosphoribosyltransferase-deficient mutants were isolated from lymphocytes of 31 individuals drawn from both control populations and populations exposed to low doses of ionizing radiation. Southern analysis of the DNA revealed altered hybridization patterns in 15 mutants. Of these, 14 changes consisted of deletions of 2 to 40 kilobases or more.

Entities:  

Mesh：

Substances：

Year:  1987        PMID： 3821735      PMCID： PMC365158          DOI： 10.1128/mcb.7.2.956-960.1987

Source DB:  PubMed          Journal:  Mol Cell Biol        ISSN： 0270-7306            Impact factor:   4.272


  17 in total

1.  Detection of specific sequences among DNA fragments separated by gel electrophoresis.

Authors:  E M Southern
Journal:  J Mol Biol       Date:  1975-11-05       Impact factor: 5.469

2.  Measurement of in vivo mutations in human lymphocytes.

Authors:  A A Morley; K J Trainor; R Seshadri; R G Ryall
Journal:  Nature       Date:  1983-03-10       Impact factor: 49.962

3.  Structural intermediates of deletion mutagenesis: a role for palindromic DNA.

Authors:  B W Glickman; L S Ripley
Journal:  Proc Natl Acad Sci U S A       Date:  1984-01       Impact factor: 11.205

4.  Fine structure of the human hypoxanthine phosphoribosyltransferase gene.

Authors:  P I Patel; P E Framson; C T Caskey; A C Chinault
Journal:  Mol Cell Biol       Date:  1986-02       Impact factor: 4.272

5.  Molecular evidence for new mutation at the hprt locus in Lesch-Nyhan patients.

Authors:  T P Yang; P I Patel; A C Chinault; J T Stout; L G Jackson; B M Hildebrand; C T Caskey
Journal:  Nature       Date:  1984 Aug 2-8       Impact factor: 49.962

6.  Hypoxanthine-guanine phosphoribosyltransferase genes of mouse and Chinese hamster: construction and sequence analysis of cDNA recombinants.

Authors:  D S Konecki; J Brennand; J C Fuscoe; C T Caskey; A C Chinault
Journal:  Nucleic Acids Res       Date:  1982-11-11       Impact factor: 16.971

7.  Deletion and amplification of the HGPRT locus in Chinese hamster cells.

Authors:  J C Fuscoe; R G Fenwick; D H Ledbetter; C T Caskey
Journal:  Mol Cell Biol       Date:  1983-06       Impact factor: 4.272

8.  T-cell cloning to detect the mutant 6-thioguanine-resistant lymphocytes present in human peripheral blood.

Authors:  R J Albertini; K L Castle; W R Borcherding
Journal:  Proc Natl Acad Sci U S A       Date:  1982-11       Impact factor: 11.205

9.  Expression of human and Chinese hamster hypoxanthine-guanine phosphoribosyltransferase cDNA recombinants in cultured Lesch-Nyhan and Chinese hamster fibroblasts.

Authors:  J Brennand; D S Konecki; C T Caskey
Journal:  J Biol Chem       Date:  1983-08-25       Impact factor: 5.157

10.  Structure of mutant alleles at the aprt locus of Chinese hamster ovary cells.

Authors:  J Nalbantoglu; O Goncalves; M Meuth
Journal:  J Mol Biol       Date:  1983-07-05       Impact factor: 5.469
View more
  8 in total

1.  High frequency of large spontaneous deletions of DNA in tumor-derived CHEF cells.

Authors:  D A Kaden; L Bardwell; P Newmark; A Anisowicz; T R Skopek; R Sager
Journal:  Proc Natl Acad Sci U S A       Date:  1989-04       Impact factor: 11.205

2.  Fine structure mapping of the hypoxanthine-guanine phosphoribosyltransferase (HPRT) gene region of the human X chromosome (Xq26).

Authors:  J A Nicklas; T C Hunter; J P O'Neill; R J Albertini
Journal:  Am J Hum Genet       Date:  1991-08       Impact factor: 11.025

3.  Homologous plasmid recombination is elevated in immortally transformed cells.

Authors:  G K Finn; B W Kurz; R Z Cheng; R J Shmookler Reis
Journal:  Mol Cell Biol       Date:  1989-09       Impact factor: 4.272

4.  A novel class of unstable 6-thioguanine-resistant cells from dog and human kidneys.

Authors:  M S Turker; R J Monnat; K Fukuchi; P A Johnston; C E Ogburn; R E Weller; J F Park; G M Martin
Journal:  Cell Biol Toxicol       Date:  1988-06       Impact factor: 6.691

5.  Selection against blood cells deficient in hypoxanthine phosphoribosyltransferase (HPRT) in Lesch-Nyhan heterozygotes occurs at the level of multipotent stem cells.

Authors:  M Hakoda; Y Hirai; M Akiyama; H Yamanaka; C Terai; N Kamatani; S Kashiwazaki
Journal:  Hum Genet       Date:  1995-12       Impact factor: 4.132

6.  Diagnosis of heterozygous states for adenine phosphoribosyltransferase deficiency based on detection of in vivo somatic mutants in blood T cells: application to screening of heterozygotes.

Authors:  M Hakoda; H Yamanaka; N Kamatani; N Kamatani
Journal:  Am J Hum Genet       Date:  1991-03       Impact factor: 11.025

7.  Cloning of phenotypically different human lymphocytes originating from a single stem cell.

Authors:  M Hakoda; Y Hirai; H Shimba; Y Kusunoki; S Kyoizumi; Y Kodama; M Akiyama
Journal:  J Exp Med       Date:  1989-04-01       Impact factor: 14.307

Review 8.  In vivo mutations in human blood cells: biomarkers for molecular epidemiology.

Authors:  R J Albertini; J A Nicklas; J C Fuscoe; T R Skopek; R F Branda; J P O'Neill
Journal:  Environ Health Perspect       Date:  1993-03       Impact factor: 9.031
  8 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.