| Literature DB >> 6284788 |
Abstract
The human major histocompatibility complex (HLA) has been demonstrated to play two roles in the generation and expression of cytotoxic T-lymphocyte responses to virus-infected cells: (1) cytotoxic T cells can only recognize viral antigens in conjunction with antigens encoded by HLA-A and -B genes; and (2) HLA-linked genes may control the capacity to generate T-cell responses to a given virus or to virus in conjunction with particular self HLA-A and -B antigens. Analysis of T-cell responses generated in vivo to Epstein-Barr virus suggests that human T cells may recognize virus in conjunction with antigens other than the class I HLA polymorphic specificities.Entities:
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Year: 1982 PMID: 6284788 DOI: 10.1007/bf00915971
Source DB: PubMed Journal: J Clin Immunol ISSN: 0271-9142 Impact factor: 8.317