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Literature DB >> 311809

HLA-linked genetic control of the specicity of human cytotoxic T-cell responses to influenza virus.

Abstract

We have investigated elements of the genetic control of human in vitro cytotoxic T-cell responses to influenza virus-infected autologous cells by studies of a large family. The pattern of virus-immune cytotoxicity among siblings demonstrated T-cell recognition of influenza virus predominantly (greater than 90%) in association with determinants which are coded by genes linked to HLA (P less than 0.0002). Many family members consistently generated cytotoxic activity against influenza predominantly in association with antigens coded by genes of only one of their HLA haplotypes. Such haplotype preferences were consistent among HLA-identical siblings, indicating that the specificity of the T-cell response to influenza virus in association with HLA-A and -B antigens is controlled by genes linked to HLA.

Entities: Disease Species

Mesh：

Substances：
HLA Antigens

Year: 1979 PMID： 311809 PMCID： PMC2184821 DOI： 10.1084/jem.149.3.565

Source DB: PubMed Journal: J Exp Med ISSN： 0022-1007 Impact factor: 14.307

16 in total

1. Mapping of H-2 genes associated with T cell-mediated cytotoxic responses to SV40-tumour-associated specific antigens.

Authors: K Pfizenmaier; G Trinchieri; D Solter; B B Knowles
Journal: Nature Date: 1978-08-17 Impact factor: 49.962

2. Y-antigen killing by T cells of women is restricted by HLA.

Authors: E Goulmy; A Termijtelen; B A Bradley; J J van Rood
Journal: Nature Date: 1977-04-07 Impact factor: 49.962

Review 3. The immune response genes of the major histocompatibility complex.

Authors: B Benacerraf; R N Germain
Journal: Immunol Rev Date: 1978 Impact factor: 12.988

Review 4. Major histocompatibility complex restricted cell-mediated immunity.

Authors: G M Shearer; A M Schmitt-Verhulst
Journal: Adv Immunol Date: 1977 Impact factor: 3.543

5. Human cytotoxic response in vitro to trinitrophenyl-modified autologous cells. I. T cell recognition of TNP in association with widely shared antigens.

Authors: S Shaw; D L Nelson; G M Shearer
Journal: J Immunol Date: 1978-07 Impact factor: 5.422

6. Human cytotoxic response in vitro to trinitrophenyl-modified autologous cells. II. Diversity of self determinants recognized in association with TNP.

Authors: S Shaw; G M Shearer
Journal: J Immunol Date: 1978-07 Impact factor: 5.422

7. Cytotoxic T-cell responses to H-Y: mapping of the Ir genes.

Authors: M Hurme; C M Hetherington; P R Chandler; E Simpson
Journal: J Exp Med Date: 1978-03-01 Impact factor: 14.307

8. Ir-genes in H-2 regulate generation of anti-viral cytotoxic T cells. Mapping to K or D and dominance of unresponsiveness.

Authors: R M Zinkernagel; A Althage; S Cooper; G Kreeb; P A Klein; B Sefton; L Flaherty; J Stimpfling; D Shreffler; J Klein
Journal: J Exp Med Date: 1978-08-01 Impact factor: 14.307

9. Cytotoxic T-cell responses in mice infected with influenza and vaccinia viruses vary in magnitude with H-2 genotype.

Authors: P C Doherty; W E Biddison; J R Bennink; B B Knowles
Journal: J Exp Med Date: 1978-08-01 Impact factor: 14.307

10. Nonrandom inclusion of H-2K and H-2D antigens in Friend virus particles from mice of various strains.

Authors: J E Bubbers; S Chen; F Lilly
Journal: J Exp Med Date: 1978-02-01 Impact factor: 14.307

21 in total

1. A public HLA antigen associated with HLA-A9, Aw32, and Bw4.

Authors: D D Kostyu; P Cresswell; D B Amos
Journal: Immunogenetics Date: 1980 Impact factor: 2.846

Review 2. Virus-immune T cells and the major histocompatibility complex: evolution of some basic concepts over the past two years.

Authors: P C Doherty
Journal: Experientia Date: 1986-09-15

3. Characterization of the HLA-A2.2 subtype: T cell evidence for further heterogeneity.

Authors: F M Gotch; C Kelly; S A Ellis; L Wallace; A B Rickinson; J van der Poel; M J Crumpton; A J McMichael
Journal: Immunogenetics Date: 1985 Impact factor: 2.846

4. Cytomegalovirus-specific cytotoxicity mediated by non-T lymphocytes from peripheral blood of normal volunteers.

Authors: N Kirmani; R K Ginn; K K Mittal; J F Manischewitz; G V Quinnan
Journal: Infect Immun Date: 1981-11 Impact factor: 3.441

5. HLA antigen-related restriction of T lymphocyte cytotoxicity to Epstein-Barr virus.

Authors: I S Misko; D J Moss; J H Pope
Journal: Proc Natl Acad Sci U S A Date: 1980-07 Impact factor: 11.205

Review 6. The role of the human major histocompatibility complex in cytotoxic T-cell responses to virus-infected cells.

Authors: W E Biddison
Journal: J Clin Immunol Date: 1982-01 Impact factor: 8.317

7. Unusual restriction of a proliferative line reacting with influenza A and B viruses.

Authors: G Sterkers; C Hannoun; J P Levy
Journal: Immunogenetics Date: 1983 Impact factor: 2.846

8. Human leukocyte antigen-linked genetic controls for T cell-mediated cytotoxic response to mumps virus in humans.

Authors: Y Chiba; H Tsutsumi; T Nakao; A Wakisaka; M Aizawa
Journal: Infect Immun Date: 1982-02 Impact factor: 3.441

9. Functional T lymphocyte immune deficiency in a population of homosexual men who do not exhibit symptoms of acquired immune deficiency syndrome.

Authors: G M Shearer; S M Payne; L J Joseph; W E Biddison
Journal: J Clin Invest Date: 1984-08 Impact factor: 14.808

10. The human cytotoxic T cell response to influenza A vaccination.

Authors: A J McMichael; F Gotch; P Cullen; B Askonas; R G Webster
Journal: Clin Exp Immunol Date: 1981-02 Impact factor: 4.330