Literature DB >> 6283472

Variation in the sequence and modification state of the human insulin gene flanking regions.

A Ullrich, T J Dull, A Gray, J A Philips, S Peter.   

Abstract

The nucleotide sequence of a highly repetitive sequence region upstream from the human insulin gene is reported. The length of this region varies between alleles in the population, and appears to be stably transmitted to the next generation in a Mendelian fashion. There is no significant correlation between the length of this sequence and two types of diabetes mellitus. We observe variation in the cleavability of a BglI recognition site downstream from the human insulin gene, which is probably due to variable nucleotide modification. This presumed modification state appears not to be inherited, and varies between tissues within an individual and between individuals for a given tissue. Both alleles in a given tissue DNA sample are modified to the same extent.

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Year:  1982        PMID： 6283472      PMCID： PMC320605          DOI： 10.1093/nar/10.7.2225

Source DB:  PubMed          Journal:  Nucleic Acids Res        ISSN： 0305-1048            Impact factor:   16.971


  23 in total

1.  Detection of specific sequences among DNA fragments separated by gel electrophoresis.

Authors:  E M Southern
Journal:  J Mol Biol       Date:  1975-11-05       Impact factor: 5.469

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Authors:  J M Taylor; R Illmensee; J Summers
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3.  A general method for isolation of high molecular weight DNA from eukaryotes.

Authors:  N Blin; D W Stafford
Journal:  Nucleic Acids Res       Date:  1976-09       Impact factor: 16.971

4.  A new method for sequencing DNA.

Authors:  A M Maxam; W Gilbert
Journal:  Proc Natl Acad Sci U S A       Date:  1977-02       Impact factor: 11.205

5.  Genetic studies of the lac repressor. VII. On the molecular nature of spontaneous hotspots in the lacI gene of Escherichia coli.

Authors:  P J Farabaugh; U Schmeissner; M Hofer; J H Miller
Journal:  J Mol Biol       Date:  1978-12-25       Impact factor: 5.469

6.  Specific DNA methylation sites in the vicinity of the chicken beta-globin genes.

Authors:  J D McGhee; G D Ginder
Journal:  Nature       Date:  1979-08-02       Impact factor: 49.962

7.  Methylation of DNA in developing sea urchin embryos.

Authors:  P Grippo; M Iaccarino; E Parisi; E Scarano
Journal:  J Mol Biol       Date:  1968-09-14       Impact factor: 5.469

8.  Use of restriction enzymes to study eukaryotic DNA methylation: I. The methylation pattern in ribosomal DNA from Xenopus laevis.

Authors:  A P Bird; E M Southern
Journal:  J Mol Biol       Date:  1978-01-05       Impact factor: 5.469

9.  DNA methylation at a CCGG sequence in the large intron of the rabbit beta-globin gene: tissue-specific variations.

Authors:  C Waalwijk; R A Flavell
Journal:  Nucleic Acids Res       Date:  1978-12       Impact factor: 16.971

10.  The isolation and characterization of linked delta- and beta-globin genes from a cloned library of human DNA.

Authors:  R M Lawn; E F Fritsch; R C Parker; G Blake; T Maniatis
Journal:  Cell       Date:  1978-12       Impact factor: 41.582
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  30 in total

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Journal:  Nucleic Acids Res       Date:  1991-06-25       Impact factor: 16.971

2.  A genome-inspired DNA ligand for the affinity capture of insulin and insulin-like growth factor-2.

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Journal:  J Sep Sci       Date:  2009-05       Impact factor: 3.645

3.  N4-methylcytosine as a minor base in bacterial DNA.

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4.  RNA-mediated gene duplication: the rat preproinsulin I gene is a functional retroposon.

Authors:  M B Soares; E Schon; A Henderson; S K Karathanasis; R Cate; S Zeitlin; J Chirgwin; A Efstratiadis
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5.  A new hypervariable marker for the human alpha-globin gene cluster.

Authors:  A P Jarman; D R Higgs
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6.  Insulin and apolipoprotein A-1/C-III gene polymorphisms relating to hypertriglyceridaemia and diabetes mellitus.

Authors:  N I Jowett; A Rees; L G Williams; J Stocks; M A Vella; G A Hitman; J Katz; D J Galton
Journal:  Diabetologia       Date:  1984-08       Impact factor: 10.122

7.  Evolving sea urchin histone genes--nucleotide polymorphisms in the H4 gene and spacers of Strongylocentrotus purpuratus.

Authors:  L N Yager; J F Kaumeyer; E S Weinberg
Journal:  J Mol Evol       Date:  1984       Impact factor: 2.395

8.  Normal dosage of the insulin and insulin-like growth factor II genes in patients with the Beckwith-Wiedemann syndrome.

Authors:  R A Spritz; D Mager; R M Pauli; R Laxova
Journal:  Am J Hum Genet       Date:  1986-08       Impact factor: 11.025

9.  Cloning and characterization of the mouse alpha globin cluster and a new hypervariable marker.

Authors:  Q Z Zhao; X L Liang; S Mitra; G Gourdon; B P Alter
Journal:  Mamm Genome       Date:  1996-10       Impact factor: 2.957

10.  Diabetic hypertriglyceridaemia and related 5' flanking polymorphism of the human insulin gene.

Authors:  N I Jowett; L G Williams; G A Hitman; D J Galton
Journal:  Br Med J (Clin Res Ed)       Date:  1984-01-14
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