Literature DB >> 6282816

Central noradrenergic neurons: a locus for the functional interplay between alpha-2 adrenoceptors and opiate receptors.

G K Aghajanian.   

Abstract

The locus coeruleus (LC) contains the largest clusters of noradrenergic neurons in the brain. Single-cell recordings in rats show that LC neurons can be inhibited by clonidine acting via alpha-2 adrenoceptors; morphine and opiate peptides are also inhibitory but act via separate opiate receptors. During states of opiate withdrawal LC neurons become hyperactive; under these conditions clonidine can normalize activity via alpha-2 adrenoceptors even when opiate receptors are blocked. These single-cell studies provide a possible mechanism for the clinical efficacy of clonidine in relieving the signs and symptoms of opiate withdrawal in human addicts.

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Year:  1982        PMID： 6282816

Source DB:  PubMed          Journal:  J Clin Psychiatry        ISSN： 0160-6689            Impact factor:   4.384


  14 in total

Review 1.  The use of α-2A adrenergic agonists for the treatment of attention-deficit/hyperactivity disorder.

Authors:  Amy F T Arnsten
Journal:  Expert Rev Neurother       Date:  2010-10       Impact factor: 4.618

2.  Role of monoamine pathways in attention and effort: effects of clonidine and methylphenidate in normal adult humans.

Authors:  C R Clark; G M Geffen; L B Geffen
Journal:  Psychopharmacology (Berl)       Date:  1986       Impact factor: 4.530

Review 3.  Orphan anxiety.

Authors:  J R Walker; G F Koob
Journal:  Proc Natl Acad Sci U S A       Date:  1997-12-23       Impact factor: 11.205

4.  Decreases in endogenous opioid peptides in the rat medullo-coerulear pathway after chronic morphine treatment.

Authors:  E J Van Bockstaele; J Peoples; A S Menko; K McHugh; G Drolet
Journal:  J Neurosci       Date:  2000-12-01       Impact factor: 6.167

5.  Simultaneous treatment of hypertension and opiate withdrawal using an alpha 2-adrenergic agonist.

Authors:  C C Bell
Journal:  J Natl Med Assoc       Date:  1983-01       Impact factor: 1.798

Review 6.  Targeting the noradrenergic system for gender-sensitive medication development for tobacco dependence.

Authors:  Terril L Verplaetse; Andrea H Weinberger; Philip H Smith; Kelly P Cosgrove; Yann S Mineur; Marina R Picciotto; Carolyn M Mazure; Sherry A McKee
Journal:  Nicotine Tob Res       Date:  2015-03-11       Impact factor: 4.244

7.  Mechanisms of withdrawal-associated increases in heroin self-administration: pharmacologic modulation of heroin vs food choice in heroin-dependent rhesus monkeys.

Authors:  S Stevens Negus; Kenner C Rice
Journal:  Neuropsychopharmacology       Date:  2008-08-13       Impact factor: 7.853

8.  Extracellular signal-regulated kinase activation in the amygdala mediates elevated plus maze behavior during opioid withdrawal.

Authors:  Rebecca S Hofford; Stephen R Hodgson; Kris W Roberts; Camron D Bryant; Christopher J Evans; Shoshana Eitan
Journal:  Behav Pharmacol       Date:  2009-10       Impact factor: 2.293

9.  A Phase 3 placebo-controlled, double-blind, multi-site trial of the alpha-2-adrenergic agonist, lofexidine, for opioid withdrawal.

Authors:  Elmer Yu; Karen Miotto; Evaristo Akerele; Ann Montgomery; Ahmed Elkashef; Robert Walsh; Ivan Montoya; Marian W Fischman; Joseph Collins; Frances McSherry; Kathy Boardman; David K Davies; Charles P O'Brien; Walter Ling; Herbert Kleber; Barbara H Herman
Journal:  Drug Alcohol Depend       Date:  2008-05-27       Impact factor: 4.492

Review 10.  Noradrenergic Mechanisms in Fentanyl-Mediated Rapid Death Explain Failure of Naloxone in the Opioid Crisis.

Authors:  Randy Torralva; Aaron Janowsky
Journal:  J Pharmacol Exp Ther       Date:  2019-09-06       Impact factor: 4.030
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