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Literature DB >> 6278443

DNA sequence of an immediate-early gene (IEmRNA-5) of herpes simplex virus type I.

Abstract

We describe a 2560 base pair herpes simplex virus type 1 (HSV-1) DNA sequence containing the entire immediate-early mRNA-5 (IEmRNA-5) gene. The 3' and 5' termini of IEmRNA-5 were mapped within this DNA sequence by single-strand specific endonuclease protection experiments. The IEmRNA-5 gene contains DNA sequences from both the unique (Us) and reiterated (TRs/IRs) regions of the HSV-1 DNA short component and is interrupted by a single intron mapping in TRs/IRs. A search of the transcribed DNA sequence revealed no initiator codon within TRs/IRs. The first ATG was located 6 bases into Us sequences and this reading frame (316 codons) was also observed in the 3' transcribed region. The oligonucleotide sequences adjacent to the IEmRNA-5 termini are discussed in relation to those of the HSV-1 thymidine kinase gene and other genes transcribed by RNA polymerase II.

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Year: 1982 PMID： 6278443 PMCID： PMC326215 DOI： 10.1093/nar/10.3.979

Source DB: PubMed Journal: Nucleic Acids Res ISSN： 0305-1048 Impact factor: 16.971

33 in total

1. Orientation of herpes simplex virus type 1 immediate early mRNA's.

Authors: J B Clements; J McLauchlan; D J McGeoch
Journal: Nucleic Acids Res Date: 1979-09-11 Impact factor: 16.971

2. Regulation of herpesvirus macromolecular synthesis. VIII. The transcription program consists of three phases during which both extent of transcription and accumulation of RNA in the cytoplasm are regulated.

Authors: P C Jones; B Roizman
Journal: J Virol Date: 1979-08 Impact factor: 5.103

Review 3. How do eucaryotic ribosomes select initiation regions in messenger RNA?

Authors: M Kozak
Journal: Cell Date: 1978-12 Impact factor: 41.582

4. Temporal regulation of herpes simplex virus type 1 transcription: location of transcripts on the viral genome.

Authors: J B Clements; R J Watson; N M Wilkie
Journal: Cell Date: 1977-09 Impact factor: 41.582

5. Transfer of purified herpes virus thymidine kinase gene to cultured mouse cells.

Authors: M Wigler; S Silverstein; L S Lee; A Pellicer; Y c Cheng; R Axel
Journal: Cell Date: 1977-05 Impact factor: 41.582

6. Cloning of herpes simplex type 1 DNA fragments in a bacteriophage lambda vector.

Authors: L W Enquist; M J Madden; P Schiop-Stanley; G F Vande Woude
Journal: Science Date: 1979-02-09 Impact factor: 47.728

7. Regulation of synthesis of herpes simplex type 1 virus mRNA during productive infection.

Authors: R I Swanstrom; E K Wagner
Journal: Virology Date: 1974-08 Impact factor: 3.616

8. Ribonucleic acid synthesis in cells infected with herpes simplex virus: controls of transcription and of RNA abundance.

Authors: N Frenkel; B Roizman
Journal: Proc Natl Acad Sci U S A Date: 1972-09 Impact factor: 11.205

9. Conservation of the primary structure at the 3' end of 18S rRNA from eucaryotic cells.

Authors: O Hagenbüchle; M Santer; J A Steitz; R J Mans
Journal: Cell Date: 1978-03 Impact factor: 41.582

10. RNA synthesis in cells infected with herpes simplex virus. XII. Sequence complexity and properties of RNA differing in extent of adenylation.

Authors: S Silvertien; R Millette; P Jones; B Roizman
Journal: J Virol Date: 1976-06 Impact factor: 5.103

38 in total

1. Site specificity of the inhibitory effects of oligo(nucleoside methylphosphonate)s complementary to the acceptor splice junction of herpes simplex virus type 1 immediate early mRNA 4.

Authors: M Kulka; C C Smith; L Aurelian; R Fishelevich; K Meade; P Miller; P O Ts'o
Journal: Proc Natl Acad Sci U S A Date: 1989-09 Impact factor: 11.205

2. The herpes simplex virus 1 RNA binding protein US11 is a virion component and associates with ribosomal 60S subunits.

Authors: R J Roller; B Roizman
Journal: J Virol Date: 1992-06 Impact factor: 5.103

3. Analysis of Ori-S sequence of HSV-1: identification of one functional DNA binding domain.

Authors: S Deb; S P Deb
Journal: Nucleic Acids Res Date: 1989-04-11 Impact factor: 16.971

4. Pre-mRNA splicing and the nuclear matrix.

Authors: S Zeitlin; A Parent; S Silverstein; A Efstratiadis
Journal: Mol Cell Biol Date: 1987-01 Impact factor: 4.272

5. Sequence and structural requirements of a herpes simplex viral DNA replication origin.

Authors: D Lockshon; D A Galloway
Journal: Mol Cell Biol Date: 1988-10 Impact factor: 4.272

6. Direct correlation between a negative autoregulatory response element at the cap site of the herpes simplex virus type 1 IE175 (alpha 4) promoter and a specific binding site for the IE175 (ICP4) protein.

Authors: M S Roberts; A Boundy; P O'Hare; M C Pizzorno; D M Ciufo; G S Hayward
Journal: J Virol Date: 1988-11 Impact factor: 5.103

7. In vitro transcription of herpes simplex virus genes: identification of a new initiation site and second intervening sequence in the immediate-early RNA-5 gene.

Authors: K L Fontichiaro; T W Beck; R L Millette
Journal: J Virol Date: 1985-01 Impact factor: 5.103

8. Cells that constitutively express the herpes simplex virus immediate-early protein ICP4 allow efficient activation of viral delayed-early genes in trans.

Authors: R H Persson; S Bacchetti; J R Smiley
Journal: J Virol Date: 1985-05 Impact factor: 5.103

9. Detailed analysis of the mRNAs mapping in the short unique region of herpes simplex virus type 1.

Authors: F J Rixon; D J McGeoch
Journal: Nucleic Acids Res Date: 1985-02-11 Impact factor: 16.971

10. Replication origins and a sequence involved in coordinate induction of the immediate-early gene family are conserved in an intergenic region of herpes simplex virus.

Authors: J L Whitton; J B Clements
Journal: Nucleic Acids Res Date: 1984-02-24 Impact factor: 16.971