Literature DB >> 2550925

Site specificity of the inhibitory effects of oligo(nucleoside methylphosphonate)s complementary to the acceptor splice junction of herpes simplex virus type 1 immediate early mRNA 4.

M Kulka1, C C Smith, L Aurelian, R Fishelevich, K Meade, P Miller, P O Ts'o.   

Abstract

Oligo(nucleoside methylphosphonate)s complementary to the splice junction of herpes simplex virus type 1 immediate early pre-mRNAs 4 and 5 caused specific inhibition of herpes simplex virus type 1 growth. The dodecamer d(TpTCCTCCTGCGG) (deoxynucleoside methylphosphonate residues in italic) caused 50% and 98% decreases in herpes simplex virus type 1 titers at concentrations of 15 microM and 100 microM, respectively. d(TpTCCTCCTGCGG) inhibited viral but not cellular protein synthesis and decreased splicing of immediate early pre-mRNAs 4 and 5. Inhibition was highly sequence specific. A psoralen derivative of d(TpTCCTCCTGCGG) that can covalently bind to complementary sequences after exposure to 365-nm irradiation caused 90-98% inhibition of virus growth in cells treated with oligomer (5 microM) and irradiated at 1-3 hr postinfection. The data suggest that oligo(nucleoside methylphosphonate)s of appropriate sequence and derivatization may be effective as antiviral agents.

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Year:  1989        PMID： 2550925      PMCID： PMC297951          DOI： 10.1073/pnas.86.18.6868

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  30 in total

1.  Photochemical cross-linking of psoralen-derivatized oligonucleoside methylphosphonates to rabbit globin messenger RNA.

Authors:  J M Kean; A Murakami; K R Blake; C D Cushman; P S Miller
Journal:  Biochemistry       Date:  1988-12-27       Impact factor: 3.162

2.  Regulation of herpesvirus macromolecular synthesis. I. Cascade regulation of the synthesis of three groups of viral proteins.

Authors:  R W Honess; B Roizman
Journal:  J Virol       Date:  1974-07       Impact factor: 5.103

3.  Detailed structural analysis of two spliced HSV-1 immediate-early mRNAs.

Authors:  F J Rixon; J B Clements
Journal:  Nucleic Acids Res       Date:  1982-04-10       Impact factor: 16.971

4.  Inhibition of thymidine kinase gene expression by anti-sense RNA: a molecular approach to genetic analysis.

Authors:  J G Izant; H Weintraub
Journal:  Cell       Date:  1984-04       Impact factor: 41.582

5.  Inhibition of Rous sarcoma virus replication and cell transformation by a specific oligodeoxynucleotide.

Authors:  P C Zamecnik; M L Stephenson
Journal:  Proc Natl Acad Sci U S A       Date:  1978-01       Impact factor: 11.205

6.  Incomplete splicing and deficient accumulation of the fiber messenger RNA in monkey cells infected by human adenovirus type 2.

Authors:  D F Klessig; L T Chow
Journal:  J Mol Biol       Date:  1980-05-15       Impact factor: 5.469

7.  The junctions between the repetitive and the short unique sequences of the herpes simplex virus genome are determined by the polypeptide-coding regions of two spliced immediate-early mRNAs.

Authors:  J L Whitton; J B Clements
Journal:  J Gen Virol       Date:  1984-03       Impact factor: 3.891

8.  Expression of immediate-early genes in herpes simplex virus type 1-infected XC cells: lack of ICP22 (68K) polypeptide.

Authors:  B Jacquemont; B Verrier; A L Epstein; I Machuca
Journal:  J Gen Virol       Date:  1984-08       Impact factor: 3.891

9.  Biochemical and biological effects of nonionic nucleic acid methylphosphonates.

Authors:  P S Miller; K B McParland; K Jayaraman; P O Ts'o
Journal:  Biochemistry       Date:  1981-03-31       Impact factor: 3.162

10.  DNA sequence of an immediate-early gene (IEmRNA-5) of herpes simplex virus type I.

Authors:  R J Watson; G F Vande Woude
Journal:  Nucleic Acids Res       Date:  1982-02-11       Impact factor: 16.971
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  27 in total

1.  Antisense delivery using protamine-oligonucleotide particles.

Authors:  M Junghans; J Kreuter; A Zimmer
Journal:  Nucleic Acids Res       Date:  2000-05-15       Impact factor: 16.971

2.  Effect of a single 3'-methylene phosphonate linkage on the conformation of an A-DNA octamer double helix.

Authors:  U Heinemann; L N Rudolph; C Alings; M Morr; W Heikens; R Frank; H Blöcker
Journal:  Nucleic Acids Res       Date:  1991-02-11       Impact factor: 16.971

3.  Intracellular distribution of microinjected antisense oligonucleotides.

Authors:  J P Leonetti; N Mechti; G Degols; C Gagnor; B Lebleu
Journal:  Proc Natl Acad Sci U S A       Date:  1991-04-01       Impact factor: 11.205

4.  Antisense oligonucleotide inhibition of hepatitis C virus gene expression in transformed hepatocytes.

Authors:  R Hanecak; V Brown-Driver; M C Fox; R F Azad; S Furusako; C Nozaki; C Ford; H Sasmor; K P Anderson
Journal:  J Virol       Date:  1996-08       Impact factor: 5.103

Review 5.  Design and application of antisense oligonucleotides in cell culture, in vivo, and as therapeutic agents.

Authors:  W Brysch; K H Schlingensiepen
Journal:  Cell Mol Neurobiol       Date:  1994-10       Impact factor: 5.046

6.  Gene-targeted inhibition of transactivation of human immunodeficiency virus type-1 (HIV-1)-LTR by antisense oligonucleotides.

Authors:  I Demirhan; O Hasselmayer; D Hofmann; A Chandra; F P Svinarchuk; V V Vlassov; J Engels; P Chandra
Journal:  Virus Genes       Date:  1995-01       Impact factor: 2.332

7.  Stably expressed antisense RNA to cytomegalovirus UL83 inhibits viral replication.

Authors:  P Dal Monte; C Bessia; A Ripalti; M P Landini; A Topilko; B Plachter; J L Virelizier; S Michelson
Journal:  J Virol       Date:  1996-04       Impact factor: 5.103

8.  Oligonucleotide clamps arrest DNA synthesis on a single-stranded DNA target.

Authors:  C Giovannangeli; N T Thuong; C Hélène
Journal:  Proc Natl Acad Sci U S A       Date:  1993-11-01       Impact factor: 11.205

9.  Antiviral activity of a phosphorothioate oligonucleotide complementary to RNA of the human cytomegalovirus major immediate-early region.

Authors:  R F Azad; V B Driver; K Tanaka; R M Crooke; K P Anderson
Journal:  Antimicrob Agents Chemother       Date:  1993-09       Impact factor: 5.191

10.  In vitro effect of antisense oligonucleotides on human immunodeficiency virus type 1 reverse transcription.

Authors:  B Bordier; C Hélène; P J Barr; S Litvak; L Sarih-Cottin
Journal:  Nucleic Acids Res       Date:  1992-11-25       Impact factor: 16.971
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