Literature DB >> 6277735

Structure, stability, methylation, expression and glucocorticoid induction of endogenous and transfected proviral genes of mouse mammary tumor virus in mouse fibroblasts.

N E Hynes, U Rahmsdorf, N Kennedy, L Fabiani, R Michalides, R Nusse, B Groner.   

Abstract

A sequence of mouse genomic DNA containing an endogenous mouse mammary tumor virus (MMTV) provirus, which was isolated by molecular cloning in lambda vector phage, has been reintroduced into cultured mouse L cells, using the thymidine-kinase cotransfection technique. Individual cell clones that acquired the transfected MMTV proviral DNA have been isolated. The transfected DNA remains stable in these cells and does not become methylated. It is transcribed into MMTV RNA, And the transcription is stimulated by glucocorticoid hormones.

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Year:  1981        PMID： 6277735     DOI： 10.1016/0378-1119(81)90174-8

Source DB:  PubMed          Journal:  Gene        ISSN： 0378-1119            Impact factor:   3.688


  10 in total

1.  Characterization of an endogenous retrovirus-repetitive DNA chimera in the mouse genome.

Authors:  T G Fanning; D W Morris; R D Cardiff; H D Bradshaw
Journal:  J Virol       Date:  1985-03       Impact factor: 5.103

Review 2.  Control of gene expression by glucocorticoid hormones.

Authors:  G G Rousseau
Journal:  Biochem J       Date:  1984-11-15       Impact factor: 3.857

3.  Transcription initiation of transfected mouse mammary tumor virus LTR DNA is regulated by glucocorticoid hormones.

Authors:  B Groner; N E Hynes; U Rahmsdorf; H Ponta
Journal:  Nucleic Acids Res       Date:  1983-07-25       Impact factor: 16.971

4.  Increased concentration of an indigenous proviral mouse mammary tumor virus long terminal repeat-containing transcript is associated with neoplastic transformation of mammary epithelium in C3H/Sm mice.

Authors:  D E Graham; D Medina; G H Smith
Journal:  J Virol       Date:  1984-03       Impact factor: 5.103

5.  Cloned mouse mammary tumor virus DNA exhibits glucocorticoid-dependent expression in simian virus 40-transformed mink cells.

Authors:  D Owen; H Diggelmann
Journal:  J Virol       Date:  1983-01       Impact factor: 5.103

6.  The changes in proviral chromatin that accompany morphological variation in avian sarcoma virus-infected rat cells.

Authors:  D J Chiswell; D A Gillespie; J A Wyke
Journal:  Nucleic Acids Res       Date:  1982-07-10       Impact factor: 16.971

Review 7.  Eukaryotic DNA methylation.

Authors:  D N Cooper
Journal:  Hum Genet       Date:  1983       Impact factor: 4.132

8.  New acceptor cell for transfected genomic DNA: oncogene transfer into a mouse mammary epithelial cell line.

Authors:  N E Hynes; R Jaggi; S C Kozma; R Ball; D Muellener; N T Wetherall; B W Davis; B Groner
Journal:  Mol Cell Biol       Date:  1985-01       Impact factor: 4.272

9.  Subfragments of the large terminal repeat cause glucocorticoid-responsive expression of mouse mammary tumor virus and of an adjacent gene.

Authors:  N Hynes; A J van Ooyen; N Kennedy; P Herrlich; H Ponta; B Groner
Journal:  Proc Natl Acad Sci U S A       Date:  1983-06       Impact factor: 11.205

10.  The chromosomal integration site determines the tissue-specific methylation of mouse mammary tumour virus proviral genes.

Authors:  W H Günzburg; B Groner
Journal:  EMBO J       Date:  1984-05       Impact factor: 11.598
  10 in total

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