| Literature DB >> 6272968 |
A K Saemundsen, D T Purtilo, K Sakamoto, J L Sullivan, A C Synnerholm, D Hanto, R Simmons, M Anvret, R Collins, G Klein.
Abstract
Tissues from patients thought to have Epstein-Barr virus (EBV)-induced lymphoproliferative diseases were probed for EBV genomes using 2 independent hybridization techniques. Tissues from six patients with the X-linked lymphoproliferative syndrome, all five renal allograft recipients with immunoblastic sarcoma, and eight patients with diverse types of immunodeficiency and lymphoproliferative diseases such as fatal infectious mononucleosis or malignant lymphoma associated with antecedent immunodeficiency contained significant numbers of EBV genome equivalents per cell. The use of 2 hybridization probes is recommended to confirm the presence of EBV genomes. The finding of significant numbers of EBV genomes in tissues from patients with immunodeficiency suggests that EBV is the etiological agent of the associated lymphoproliferative diseases.Entities:
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Year: 1981 PMID： 6272968
Source DB: PubMed Journal: Cancer Res ISSN： 0008-5472 Impact factor: 12.701