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Literature DB >> 2156435

The detection of Epstein-Barr virus in hairy cell leukemia cells by in situ hybridization.

B C Wolf¹, A W Martin, R S Neiman, A J Janckila, L T Yam, A Caracansi, B A Leav, R Winpenny, D S Schultz, H J Wolfe.

Abstract

Epstein-Barr virus (EBV) has been implicated in the pathogenesis of several B-cell lymphoid proliferations. Because patients with hairy cell leukemia (HCL) have a high incidence of seropositivity for EBV antigens, we studied the cells of HCL for evidence of EBV infection using in situ hybridization techniques. EBV mRNA was detected in the tumor cells in four of six cases using a radiolabeled RNA probe. Confirmatory serologic data were available in three cases in which the viral DNA was detected and in one negative case. Our results suggest that EBV infection may have a pathogenetic role in this disorder.

Entities: Disease Species

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Year: 1990 PMID： 2156435 PMCID： PMC1877477

Source DB: PubMed Journal: Am J Pathol ISSN： 0002-9440 Impact factor: 4.307

50 in total

1. Purification of the Epstein-Barr virus/C3d complement receptor of human B lymphocytes: antigenic and functional properties of the purified protein.

Authors: G R Nemerow; M F Siaw; N R Cooper
Journal: J Virol Date: 1986-05 Impact factor: 5.103

2. Epstein-Barr virus gp350/220 binding to the B lymphocyte C3d receptor mediates adsorption, capping, and endocytosis.

Authors: J Tanner; J Weis; D Fearon; Y Whang; E Kieff
Journal: Cell Date: 1987-07-17 Impact factor: 41.582

3. Generation of specific cytotoxic T cells with a fragment of the Epstein-Barr virus-encoded p63/latent membrane protein.

Authors: D A Thorley-Lawson; E S Israelsohn
Journal: Proc Natl Acad Sci U S A Date: 1987-08 Impact factor: 11.205

9. Serologic studies in hairy cell leukemia: high prevalence of Epstein-Barr and cytomegalovirus antibodies and absence of human T-cell lymphotrophic viruses antibodies.

Authors: J R Quesada; J Reuben; R L Hopfer; F K Mundon; E M Hersh
Journal: Leuk Res Date: 1986 Impact factor: 3.156

10. Molecular cloning of the lymphocyte activation marker Blast-1.

Authors: D E Staunton; D A Thorley-Lawson
Journal: EMBO J Date: 1987-12-01 Impact factor: 11.598

1 in total

1. A survey of Epstein-Barr virus gene expression in sporadic non-Hodgkin's lymphomas. Detection of Epstein-Barr virus in a subset of peripheral T-cell lymphomas.

Authors: S J Hamilton-Dutoit; G Pallesen
Journal: Am J Pathol Date: 1992-06 Impact factor: 4.307

1 in total

The detection of Epstein-Barr virus in hairy cell leukemia cells by in situ hybridization.

1. Purification of the Epstein-Barr virus/C3d complement receptor of human B lymphocytes: antigenic and functional properties of the purified protein.

2. Epstein-Barr virus gp350/220 binding to the B lymphocyte C3d receptor mediates adsorption, capping, and endocytosis.

3. Generation of specific cytotoxic T cells with a fragment of the Epstein-Barr virus-encoded p63/latent membrane protein.

4. Epstein-Barr viral DNA in tissues of Hodgkin's disease.

5. Cytochemical, cytogenetic, immunophenotypic and tumorigenic characterization of two hairy cell lines.

6. EB virus induction is associated with B-cell maturation.

7. Non-Hodgkin's lymphoma after treatment of Hodgkin's disease: association with Epstein-Barr virus.

Review 8. Cancer is a complication of severe immunosuppression.

9. Serologic studies in hairy cell leukemia: high prevalence of Epstein-Barr and cytomegalovirus antibodies and absence of human T-cell lymphotrophic viruses antibodies.

10. Molecular cloning of the lymphocyte activation marker Blast-1.

1. A survey of Epstein-Barr virus gene expression in sporadic non-Hodgkin's lymphomas. Detection of Epstein-Barr virus in a subset of peripheral T-cell lymphomas.