| Literature DB >> 6272967 |
D T Purtilo, K Sakamoto, A K Saemundsen, J L Sullivan, A C Synnerholm, M Anvret, J Pritchard, C Sloper, C Sieff, J Pincott, L Pachman, K Rich, F Cruzi, J A Cornet, R Collins, N Barnes, J Knight, B Sandstedt, G Klein.
Abstract
Multiple methods, pedigree analysis, clinical evaluation, and Epstein-Barr virus (EBV)-specific serology, EBV DNA hybridization of tissues to probe for viral genome, staining of touch imprints for EBV nuclear-associated antigen, establishment of spontaneous infected B-cell lines from peripheral blood or tissues, examination of peripheral blood smears, and hematopathology studies, were used to study seven patients with the X-linked lymphoproliferative syndrome and seven additional patients with life-threatening EBV-associated diseases. These studies demonstrated EBV in the tissues of all 14 patients and immunodeficient antibody responses to EBV were documented. This virus can produce various life-threatening lymphoproliferative diseases in a variety of immunodeficient patients.Entities:
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Year: 1981 PMID： 6272967
Source DB: PubMed Journal: Cancer Res ISSN： 0008-5472 Impact factor: 12.701