Literature DB >> 6272934

Age dependent changes in the methylation of rat brain phospholipids.

F T Crews, G Calderini, A Battistella, G Toffano.   

Abstract

Phospholipid methyltransferase I and II enzymes methylate phosphatidylethanolamine three times to form phosphatidylcholine. The activity of these two enzymes was determined in synaptosome-enriched fractions from rats 1, 3, 7, 15 and 21 months old. The activity of phospholipid methyltransferase I was significantly greater in 7-, 15- and 21-month-old rats than in 1- and 3-month-old rats. In contrast, the activity of phospholipid methyltransferase II did not change with age. These changes in methyltransferase activity with increasing age may be related to changes in beta-receptor function with increasing age.

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Year:  1981        PMID： 6272934     DOI： 10.1016/0006-8993(81)90767-8

Source DB:  PubMed          Journal:  Brain Res        ISSN： 0006-8993            Impact factor:   3.252


  7 in total

1.  Sexually dimorphic activation of liver and brain phosphatidylethanolamine N-methyltransferase by dietary choline deficiency.

Authors:  P I Johnson; J K Blusztajn
Journal:  Neurochem Res       Date:  1998-05       Impact factor: 3.996

2.  Entry of polyunsaturated fatty acids into the brain: evidence that high-density lipoprotein-induced methylation of phosphatidylethanolamine and phospholipase A2 are involved.

Authors:  V Magret; L Elkhalil; F Nazih-Sanderson; F Martin; J M Bourre; J C Fruchart; C Delbart
Journal:  Biochem J       Date:  1996-06-15       Impact factor: 3.857

3.  Effects of aging on the interaction of quinuclidinyl benzilate, N-methylscopolamine, pirenzepine, and gallamine with brain muscarinic receptors.

Authors:  W Surichamorn; O N Kim; N H Lee; W S Lai; E E el-Fakahany
Journal:  Neurochem Res       Date:  1988-12       Impact factor: 3.996

Review 4.  Age-associated changes in central nervous system glycerolipid composition and metabolism.

Authors:  N M Giusto; G A Salvador; P I Castagnet; S J Pasquaré; M G Ilincheta de Boschero
Journal:  Neurochem Res       Date:  2002-11       Impact factor: 3.996

5.  Developmental changes in the activity of phosphatidylethanolamine N-methyltransferases in rat brain.

Authors:  J K Blusztajn; S H Zeisel; R J Wurtman
Journal:  Biochem J       Date:  1985-12-01       Impact factor: 3.857

6.  Microinfusion of clonidine and yohimbine into locus coeruleus alters EEG power spectrum: effects of aging and reversal by phosphatidylserine.

Authors:  G B de Sarro; G Bagetta; C Ascioti; V Libri; G Nisticò
Journal:  Br J Pharmacol       Date:  1988-12       Impact factor: 8.739

7.  Biochemical changes of rat brain membranes with aging.

Authors:  G Calderini; A C Bonetti; A Battistella; F T Crews; G Toffano
Journal:  Neurochem Res       Date:  1983-04       Impact factor: 3.996
  7 in total

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