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Literature DB >> 6267006

Identification of the tetracycline resistance promoter and repressor in transposon Tn10.

Abstract

The structural and regulatory functions encoding tetracycline resistance in transposon Tn10 lie within a 2,700-base pair region. Using recombinant plasmids with different deoxyribonucleic acid sequences adjacent to a HincII site in this region, we located the promoter controlling the expression of tetracycline resistance. These various sequences conferred altered levels of tetracycline resistance. Plasmids containing deletions of a 695-base pair HincII fragment were constitutive and showed the loss of a 23,000-dalton tetracycline-inducible polypeptide, thus identifying the repressor and the location of its gene.

Entities: Chemical Species

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Year: 1981 PMID： 6267006 PMCID： PMC216045 DOI： 10.1128/jb.147.2.297-304.1981

Source DB: PubMed Journal: J Bacteriol ISSN： 0021-9193 Impact factor: 3.490

40 in total

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Authors: R C Dickson; J Abelson; W M Barnes; W S Reznikoff
Journal: Science Date: 1975-01-10 Impact factor: 47.728

2. Control regions within the argECBH gene cluster of Escherichia coli K12.

Authors: D Elseviers; R Cunin; N Glansdorff
Journal: Mol Gen Genet Date: 1972

3. Sequence of a repressor-binding site in the DNA of bacteriophage lamda.

Authors: T Maniatis; M Ptashne; B G Barrell; J Donelson
Journal: Nature Date: 1974-08-02 Impact factor: 49.962

4. Divergent orientation of transcription from the biotin locus of Escherichia coli.

Authors: A Guha
Journal: J Mol Biol Date: 1971-02-28 Impact factor: 5.469

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Authors: M Mandel; A Higa
Journal: J Mol Biol Date: 1970-10-14 Impact factor: 5.469

6. Specificity and mechanism of tetracycline resistance in a multiple drug resistant strain of Escherichia coli.

Authors: K Izaki; K Kiuchi; K Arima
Journal: J Bacteriol Date: 1966-02 Impact factor: 3.490

7. A simple method for the preparation of large quantities of pure plasmid DNA.

Authors: G O Humphreys; G A Willshaw; E S Anderson
Journal: Biochim Biophys Acta Date: 1975-04-02

8. The lexA gene product represses its own promoter.

Authors: R Brent; M Ptashne
Journal: Proc Natl Acad Sci U S A Date: 1980-04 Impact factor: 11.205

9. Nucleotide sequence of an RNA polymerase binding site from the DNA of bacteriophage fd.

Authors: H Schaller; C Gray; K Herrmann
Journal: Proc Natl Acad Sci U S A Date: 1975-02 Impact factor: 11.205

10. Nucleotide sequence of the rightward operator of phage lambda.

Authors: T Maniatis; A Jeffrey; D G Kleid
Journal: Proc Natl Acad Sci U S A Date: 1975-03 Impact factor: 11.205

45 in total

1. New tetracycline resistance determinant on R plasmids from Vibrio anguillarum.

Authors: T Aoki; T Satoh; T Kitao
Journal: Antimicrob Agents Chemother Date: 1987-09 Impact factor: 5.191

Review 2. The TetR family of regulators.

Authors: Leslie Cuthbertson; Justin R Nodwell
Journal: Microbiol Mol Biol Rev Date: 2013-09 Impact factor: 11.056

3. Characterization of the tol-pal and cyd region of Escherichia coli K-12: transcript analysis and identification of two new proteins encoded by the cyd operon.

Authors: M M Muller; R E Webster
Journal: J Bacteriol Date: 1997-03 Impact factor: 3.490

10. Analysis of tetracycline resistance encoded by transposon Tn10: deletion mapping of tetracycline-sensitive point mutations and identification of two structural genes.

Authors: D C Coleman; I Chopra; S W Shales; T G Howe; T J Foster
Journal: J Bacteriol Date: 1983-02 Impact factor: 3.490