Literature DB >> 6265943

A highly potent 3200-dalton adrenal opioid peptide that contains both a [Met]- and [Leu]enkephalin sequence.

D L Kilpatrick, T Taniguchi, B N Jones, A S Stern, J E Shively, J Hullihan, S Kimura, S Stein, S Udenfriend.   

Abstract

A 3200-dalton adrenal enkephalin-containing peptide, designated peptide E, that exhibits high opiate activity in the guinea pig ileum longitudinal muscle preparation was purified, and its structure was determined. It contains an amino-terminal [Met]enkephalin sequence and a [Leu]enkephalin sequence at the carboxyl terminus. Sequence analysis revealed that peptide E arises from a previously characterized 4900-dalton adrenal enkephalin-containing peptide. Peptide E was shown to be 30 times more potent than [Met]enkephalin in the guinea pig ileum assay, which suggests that the adrenal enkephalin-containing peptide may perform a unique biological function in vivo.

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Year:  1981        PMID： 6265943      PMCID： PMC319542          DOI： 10.1073/pnas.78.5.3265

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  19 in total

1.  Dynorphin-(1-13), an extraordinarily potent opioid peptide.

Authors:  A Goldstein; S Tachibana; L I Lowney; M Hunkapiller; L Hood
Journal:  Proc Natl Acad Sci U S A       Date:  1979-12       Impact factor: 11.205

2.  Probable precursors of [Leu]enkephalin and [Met]enkephalin in adrenal medulla: peptides of 3-5 kilodaltons.

Authors:  S Kimura; R V Lewis; A S Stern; J Rossier; S Stein; S Udenfriend
Journal:  Proc Natl Acad Sci U S A       Date:  1980-03       Impact factor: 11.205

3.  alpha-Neo-endorphin : a "big" Leu-enkephalin with potent opiate activity from porcine hypothalami.

Authors:  K Kangawa; H Matsuo
Journal:  Biochem Biophys Res Commun       Date:  1979-01-15       Impact factor: 3.575

4.  Amino acid analysis with fluorescamine at the picomole level.

Authors:  S Stein; P Böhlen; J Stone; W Dairman; S Udenfriend
Journal:  Arch Biochem Biophys       Date:  1973-03       Impact factor: 4.013

5.  Opiate-like materials in the adrenal medulla: evidence for storage and secretion with catecholamines.

Authors:  O H Viveros; E J Diliberto; E Hazum; K J Chang
Journal:  Mol Pharmacol       Date:  1979-11       Impact factor: 4.436

6.  Supports for reverse-phase high-performance liquid chromatography of large proteins.

Authors:  R V Lewis; A Fallon; S Stein; K D Gibson; S Udenfriend
Journal:  Anal Biochem       Date:  1980-05-01       Impact factor: 3.365

7.  Opioid peptides and precursors in the adrenal medulla.

Authors:  R V Lewis; A S Stern; S Kimura; J Rossier; L Brink; L D Gerber; S Stein; S Udenfriend
Journal:  Adv Biochem Psychopharmacol       Date:  1980

8.  An about 50,000-dalton protein in adrenal medulla: a common precursor of [Met]- and [Leu]enkephalin.

Authors:  R V Lewis; A S Stern; S Kimura; J Rossier; S Stein; S Udenfriend
Journal:  Science       Date:  1980-06-27       Impact factor: 47.728

9.  Isolation of the opioid heptapeptide Met-enkephalin [Arg6,Phe7] from bovine adrenal medullary granules and striatum.

Authors:  A S Stern; R V Lewis; S Kimura; J Rossier; L D Gerber; L Brink; S Stein; S Udenfriend
Journal:  Proc Natl Acad Sci U S A       Date:  1979-12       Impact factor: 11.205

10.  The effects of adrenaline, noradrenaline and isoprenaline on inhibitory alpha- and beta-adrenoceptors in the longitudinal muscle of the guinea-pig ileum.

Authors:  H W Kosterlitz; R J Lydon; A J Watt
Journal:  Br J Pharmacol       Date:  1970-06       Impact factor: 8.739
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  19 in total

1.  Effects of hypnosis on plasma proenkephalin peptide F and perceptual and cardiovascular responses during submaximal exercise.

Authors:  W J Kraemer; R V Lewis; N T Triplett; L P Koziris; S Heyman; B J Noble
Journal:  Eur J Appl Physiol Occup Physiol       Date:  1992

2.  Secondary structure characteristics of proenkephalin peptides E, B, and F.

Authors:  H J Hiddinga; G E Katzenstein; C R Middaugh; R V Lewis
Journal:  Neurochem Res       Date:  1990-04       Impact factor: 3.996

3.  Opioid peptides.

Authors:  J W Thompson
Journal:  Br Med J (Clin Res Ed)       Date:  1984-01-28

4.  Isolation and amino acid sequence analysis of a 4,000-dalton dynorphin from porcine pituitary.

Authors:  W Fischli; A Goldstein; M W Hunkapiller; L E Hood
Journal:  Proc Natl Acad Sci U S A       Date:  1982-09       Impact factor: 11.205

5.  Rimorphin, a unique, naturally occurring [Leu]enkephalin-containing peptide found in association with dynorphin and alpha-neo-endorphin.

Authors:  D L Kilpatrick; A Wahlstrom; H W Lahm; R Blacher; S Udenfriend
Journal:  Proc Natl Acad Sci U S A       Date:  1982-11       Impact factor: 11.205

6.  Methionine-enkephalin-like immunoreactivity in the nervous ganglion and the ovary of a protochordate, Ciona intestinalis.

Authors:  D Georges; M P Dubois
Journal:  Cell Tissue Res       Date:  1984       Impact factor: 5.249

Review 7.  Enkephalins and Endorphins. Clinical, pharmacological and therapeutic implications.

Authors:  D L Copolov; R D Helme
Journal:  Drugs       Date:  1983-12       Impact factor: 9.546

8.  Molecular forms of the putative enkephalin precursor BAM-12P in bovine adrenal, pituitary, and hypothalamus.

Authors:  A Baird; N Ling; P Böhlen; R Benoit; R Klepper; R Guillemin
Journal:  Proc Natl Acad Sci U S A       Date:  1982-03       Impact factor: 11.205

9.  Proenkephalin, [Met]enkephalin, and oxytocin immunoreactivities are colocalized in bovine hypothalamic magnocellular neurons.

Authors:  J J Vanderhaeghen; F Lotstra; D R Liston; J Rossier
Journal:  Proc Natl Acad Sci U S A       Date:  1983-08       Impact factor: 11.205

10.  Differential processing of proenkephalin-A by human peripheral blood monocytes and T lymphocytes.

Authors:  W Kuis; P M Villiger; H G Leser; M Lotz
Journal:  J Clin Invest       Date:  1991-09       Impact factor: 14.808
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