Literature DB >> 6265810

Effects of some GABA-mimetic drugs on the antinociceptive activity of morphine and beta-endorphin in rats.

N Zonta, F Zambotti, L Vicentini, R Tammiso, P Mantegazza.   

Abstract

Intracerebroventricular administration of muscimol, a potent GABA-receptor agonist, counteracted the antinociceptive effect of morphine or beta-endorphin in rats as measured by the "tail flick" method. Muscimol's activity was reversed by bicuculline. Isoguvacine, another GABA agonist, as well as nipecotic acid and guvacine, two inhibitors of neuronal and glial uptake of GABA, also antagonized morphine's antinociceptive effect. A role of the central GABA-ergic system in mediating opiate antinociception is proposed.

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Year:  1981        PMID： 6265810     DOI： 10.1007/bf00505654

Source DB:  PubMed          Journal:  Naunyn Schmiedebergs Arch Pharmacol        ISSN： 0028-1298            Impact factor:   3.000


  21 in total

1.  Betel nut constituents as inhibitors of gamma-aminobutyric acid uptake.

Authors:  G A Johnston; P Krogsgaard-Larsen; A Stephanson
Journal:  Nature       Date:  1975-12-18       Impact factor: 49.962

2.  Systematic examination in the rat of brain sites sensitive to the direct application of morphine: observation of differential effects within the periaqueductal gray.

Authors:  T L Yaksh; J C Yeung; T A Rudy
Journal:  Brain Res       Date:  1976-09-10       Impact factor: 3.252

3.  Pharmacological manipulation of gamma-aminobutyric acid (GABA) in morphine analgesia, tolerance and physical dependence.

Authors:  I K Ho; H H Loh; E L Way
Journal:  Life Sci       Date:  1976-05-15       Impact factor: 5.037

4.  Characteristics of muscimol accumulation in mouse brain after systemic administration.

Authors:  A Maggi; S J Enna
Journal:  Neuropharmacology       Date:  1979-04       Impact factor: 5.250

5.  The in vivo neuropharmacology of amino-oxyacetic acid in the cerebral cortex of the cat.

Authors:  Z Gottesfeld; J S Kelly; L P Renaud
Journal:  Brain Res       Date:  1972-07-20       Impact factor: 3.252

6.  A simple and inexpensive cannula technique for chemical stimulation of the brain.

Authors:  F B Altaffer; F S Verster; S Hall; C J Long; P D'encarnacao
Journal:  Physiol Behav       Date:  1970-01

7.  Effects of intraventricular beta-endorphin on GABA system in some areas of chick brain.

Authors:  G Nisticò; R M Di Giorgio; D Rotiroti; F Naccari; A Calatroni
Journal:  Res Commun Chem Pathol Pharmacol       Date:  1979-12

8.  Effects of taurine and gamma-aminobutyric acid on akinesia and analgesia induced by D-Ala2-Met-enkephalinamide in rats.

Authors:  K Izumi; E Munekata; H Yamamoto; T Nakanishi; A Barbeau
Journal:  Peptides       Date:  1980       Impact factor: 3.750

9.  Muscimol antagonism of morphine analgesia in rats.

Authors:  P Mantegazza; R Tammiso; L Vicentini; F Zambotti; N Zonta
Journal:  Br J Pharmacol       Date:  1979-09       Impact factor: 8.739

10.  Antinociceptive effects of baclofen and muscimol upon intraventricular administration.

Authors:  J M Liebman; G Pastor
Journal:  Eur J Pharmacol       Date:  1980-02-08       Impact factor: 4.432
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  9 in total

1.  Reversal of the effect of centrally-administered diazepam on morphine antinociception by specific (Ro 15-1788 and Ro 15-3505) and non-specific (bicuculline and caffeine) benzodiazepine antagonists.

Authors:  F Zambotti; N Zonta; R Tammiso; P Ferrario; B Hafner; P Mantegazza
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1986-05       Impact factor: 3.000

2.  Entanglement between thermoregulation and nociception in the rat: the case of morphine.

Authors:  Nabil El Bitar; Bernard Pollin; Elias Karroum; Ivanne Pincedé; Daniel Le Bars
Journal:  J Neurophysiol       Date:  2016-09-07       Impact factor: 2.714

3.  Differential modulation by muscimol and baclofen on antinociception induced by morphine, beta-endorphin, D-Pen2,5-enkephalin and U50,488H administered intracerebroventricularly in the mouse.

Authors:  H W Suh; D K Song; Y H Kim; Y S Choi; J S Yoo; L F Tseng
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1995-12       Impact factor: 3.000

4.  CC12, a high-affinity ligand for [3H]cimetidine binding, is an improgan antagonist.

Authors:  Lindsay B Hough; Julia W Nalwalk; James G Phillips; Brian Kern; Zhixing Shan; Mark P Wentland; Iwan J P de Esch; Elwin Janssen; Travis Barr; Rebecca Stadel
Journal:  Neuropharmacology       Date:  2007-01-20       Impact factor: 5.250

5.  Modification of the antinociceptive effect of morphine by centrally administered diazepam and midazolam.

Authors:  P Mantegazza; M Parenti; R Tammiso; P Vita; F Zambotti; N Zonta
Journal:  Br J Pharmacol       Date:  1982-04       Impact factor: 8.739

6.  Effects of diazepam on nociception in rats.

Authors:  F Zambotti; N Zonta; R Tammiso; F Conci; B Hafner; L Zecca; P Ferrario; P Mantegazza
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1991-07       Impact factor: 3.000

7.  Periaqueductal gray matter involvement in the muscimol-induced decrease of morphine antinociception.

Authors:  F Zambotti; N Zonta; M Parenti; R Tommasi; L Vicentini; F Conci; P Mantegazza
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1982-03       Impact factor: 3.000

8.  Zopiclone potentiates the antinociceptive effect of morphine in rats.

Authors:  F Zambotti; N Zonta; R Tammiso; F Conci; B Hafner; P Ferrario; L Zecca; P Mantegazza
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1987-11       Impact factor: 3.000

Review 9.  Polydrug abuse: a review of opioid and benzodiazepine combination use.

Authors:  Jermaine D Jones; Shanthi Mogali; Sandra D Comer
Journal:  Drug Alcohol Depend       Date:  2012-08-02       Impact factor: 4.492
  9 in total

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