Literature DB >> 6121598

Modification of the antinociceptive effect of morphine by centrally administered diazepam and midazolam.

P Mantegazza, M Parenti, R Tammiso, P Vita, F Zambotti, N Zonta.   

Abstract

1 Intracerebroventricular administration of diazepam or midazolam decreased the antinociceptive effect of morphine in rats as measured by the "tail flick" method. 2 Midazolam, injected into the periaqueductal grey matter (PAG) antagonized the analgesic effect of morphine. The action of midazolam was partially reversed by bicuculline. 3 These findings support the view that the effect of benzodiazephines on morphine antinociception may be mediated through gamma-aminobutyric acid receptors.

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Year:  1982        PMID： 6121598      PMCID： PMC2071525          DOI： 10.1111/j.1476-5381.1982.tb09175.x

Source DB:  PubMed          Journal:  Br J Pharmacol        ISSN： 0007-1188            Impact factor:   8.739


  18 in total

1.  Possible involvement of GABA in morphine analgesia.

Authors:  Y Yoneda; S Takashima; K Kuriyama
Journal:  Biochem Pharmacol       Date:  1976-12-01       Impact factor: 5.858

2.  Pharmacological manipulation of gamma-aminobutyric acid (GABA) in morphine analgesia, tolerance and physical dependence.

Authors:  I K Ho; H H Loh; E L Way
Journal:  Life Sci       Date:  1976-05-15       Impact factor: 5.037

3.  Pharmacology of medazepam and metabolites.

Authors:  L O Randall; C L Scheckel; W Pool
Journal:  Arch Int Pharmacodyn Ther       Date:  1970-05

4.  The effect of benzodiazepines on the analgesic effect of morphine and sodium salicylate.

Authors:  M R Fennessy; J Sawynok
Journal:  Arch Int Pharmacodyn Ther       Date:  1973-07

5.  A simple and inexpensive cannula technique for chemical stimulation of the brain.

Authors:  F B Altaffer; F S Verster; S Hall; C J Long; P D'encarnacao
Journal:  Physiol Behav       Date:  1970-01

6.  Potentiation of morphine analgesia by muscimol.

Authors:  G Biggio; D D Bella; V Frigeni; A Guidotti
Journal:  Neuropharmacology       Date:  1977-02       Impact factor: 5.250

Review 7.  Assays for narcotic antagonist activity in rodents.

Authors:  A K Pierson
Journal:  Adv Biochem Psychopharmacol       Date:  1973

8.  Interactions between narcotic analgesics and benzodiazepine derivatives on behavior in the mouse.

Authors:  H E Shannon; S G Holtzman; D C Davis
Journal:  J Pharmacol Exp Ther       Date:  1976-11       Impact factor: 4.030

9.  Pharmacology of oxazepam (Serax), a new anti-anxiety agent.

Authors:  M I Gluckman
Journal:  Curr Ther Res Clin Exp       Date:  1965-11

10.  Morphine antagonistic effect of chlordiazepoxide (Librium).

Authors:  J Weis
Journal:  Experientia       Date:  1969-04-15
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  13 in total

1.  Reversal of the effect of centrally-administered diazepam on morphine antinociception by specific (Ro 15-1788 and Ro 15-3505) and non-specific (bicuculline and caffeine) benzodiazepine antagonists.

Authors:  F Zambotti; N Zonta; R Tammiso; P Ferrario; B Hafner; P Mantegazza
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1986-05       Impact factor: 3.000

2.  The possible modulation of morphine analgesia by the supramolecular GABA receptor complex.

Authors:  O Palaoglu; I H Ayhan
Journal:  Psychopharmacology (Berl)       Date:  1986       Impact factor: 4.530

3.  Involvement of cholecystokininergic systems in anxiety-induced hyperalgesia in male rats: behavioral and biochemical studies.

Authors:  Judith Andre; Brigitte Zeau; Michel Pohl; François Cesselin; Jean-Jacques Benoliel; Chrystel Becker
Journal:  J Neurosci       Date:  2005-08-31       Impact factor: 6.167

4.  The relative significance of spinal and supraspinal actions in the antinociceptive effect of morphine in the dorsal horn: an evaluation of the microinjection technique.

Authors:  S L Clark; R O Edeson; R W Ryall
Journal:  Br J Pharmacol       Date:  1983-07       Impact factor: 8.739

5.  Midazolam exacerbates morphine tolerance and morphine-induced hyperactive behaviors in young rats with burn injury.

Authors:  Li Song; Shuxing Wang; Yunxia Zuo; Lucy Chen; Jeevendra A Martyn; Jianren Mao
Journal:  Brain Res       Date:  2014-04-05       Impact factor: 3.252

6.  Attenuation of reperfusion hyperalgesia in the rat by systemic administration of benzodiazepines.

Authors:  S M Cartmell; D Mitchell
Journal:  Br J Pharmacol       Date:  1993-11       Impact factor: 8.739

7.  Effects of diazepam on nociception in rats.

Authors:  F Zambotti; N Zonta; R Tammiso; F Conci; B Hafner; L Zecca; P Ferrario; P Mantegazza
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1991-07       Impact factor: 3.000

8.  Benzodiazepine-opiate antagonism--a problem in intensive-care therapy.

Authors:  C F McDonald; S A Thomson; N C Scott; W Scott; I W Grant; G K Crompton
Journal:  Intensive Care Med       Date:  1986       Impact factor: 17.440

9.  Zopiclone potentiates the antinociceptive effect of morphine in rats.

Authors:  F Zambotti; N Zonta; R Tammiso; F Conci; B Hafner; P Ferrario; L Zecca; P Mantegazza
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1987-11       Impact factor: 3.000

10.  Effect of the NMDA-antagonist, MK 801, on benzodiazepine-opioid interactions at the spinal and supraspinal level in rats.

Authors:  T J Luger; I H Lorenz; C Grabner-Weiss; T Hayashi
Journal:  Br J Pharmacol       Date:  1995-03       Impact factor: 8.739
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