Literature DB >> 497517

Muscimol antagonism of morphine analgesia in rats.

P Mantegazza, R Tammiso, L Vicentini, F Zambotti, N Zonta.   

Abstract

1 Muscimol, a gamma-aminobutyric acid (GABA) receptor agonist, when injected intraventricularly antagonizes the antinociceptive effect of morphine given either subcutaneously or intraventricularly. The antagonistic effect of muscimol on morphine analgesia appears to be linearly related. 2 This finding provides support for the view that a GABA-ergic system is involved in morphine analgesia.

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Year:  1979        PMID： 497517      PMCID： PMC2043611     

Source DB:  PubMed          Journal:  Br J Pharmacol        ISSN： 0007-1188            Impact factor:   8.739


  15 in total

1.  Possible involvement of GABA in morphine analgesia.

Authors:  Y Yoneda; S Takashima; K Kuriyama
Journal:  Biochem Pharmacol       Date:  1976-12-01       Impact factor: 5.858

2.  Systematic examination in the rat of brain sites sensitive to the direct application of morphine: observation of differential effects within the periaqueductal gray.

Authors:  T L Yaksh; J C Yeung; T A Rudy
Journal:  Brain Res       Date:  1976-09-10       Impact factor: 3.252

3.  Use of 3H-muscimol for GABA receptor studies.

Authors:  S R Snodgrass
Journal:  Nature       Date:  1978-06-01       Impact factor: 49.962

4.  Effect of muscimol on single unit activity of substantia nigra dopamine neurons.

Authors:  J R Walters; J M Lakoski
Journal:  Eur J Pharmacol       Date:  1978-02-15       Impact factor: 4.432

5.  Potentiation of morphine analgesia by muscimol.

Authors:  G Biggio; D D Bella; V Frigeni; A Guidotti
Journal:  Neuropharmacology       Date:  1977-02       Impact factor: 5.250

6.  Muscimol antagonizes morphine hypermotility without potentiation of analgesia.

Authors:  A V Christensen; J Arnt; J Scheel-Krüger
Journal:  Eur J Pharmacol       Date:  1978-04-15       Impact factor: 4.432

7.  Gabaergic processes involved in the control of dopamine release from nigrostriatal dopaminergic neurons in the cat.

Authors:  A Chéramy; A Nieoullon; J Glowinski
Journal:  Eur J Pharmacol       Date:  1978-04-01       Impact factor: 4.432

8.  Studies on the antagonism by raphe lesions of the antinociceptive action of systemic morphine.

Authors:  T L Yaksh; R L Plant; T A Rudy
Journal:  Eur J Pharmacol       Date:  1977-02-21       Impact factor: 4.432

9.  Morphine induced alterations of gamma-aminobutyric acid and taurine contents and L-glutamate decarboxylase activity in rat spinal cord and thalamus: possible correlates with analgesic action of morphine.

Authors:  K Kuriyama; Y Yoneda
Journal:  Brain Res       Date:  1978-06-09       Impact factor: 3.252

10.  Mesencephalic and diencephalic afferents to the superior colliculus and periaqueductal gray substance demonstrated by retrograde axonal transport of horseradish peroxidase in the cat.

Authors:  I Grofová; O P Ottersen; E Rinvik
Journal:  Brain Res       Date:  1978-05-12       Impact factor: 3.252
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  10 in total

1.  The possible modulation of morphine analgesia by the supramolecular GABA receptor complex.

Authors:  O Palaoglu; I H Ayhan
Journal:  Psychopharmacology (Berl)       Date:  1986       Impact factor: 4.530

2.  Antinociceptive activity of CC44, a biotinylated improgan congener.

Authors:  Paul Hoerbelt; Julia W Nalwalk; James G Phillips; Mark P Wentland; Zhixing Shan; Lindsay B Hough
Journal:  Eur J Pharmacol       Date:  2013-07-05       Impact factor: 4.432

3.  Differential modulation by muscimol and baclofen on antinociception induced by morphine, beta-endorphin, D-Pen2,5-enkephalin and U50,488H administered intracerebroventricularly in the mouse.

Authors:  H W Suh; D K Song; Y H Kim; Y S Choi; J S Yoo; L F Tseng
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1995-12       Impact factor: 3.000

4.  Modification of the antinociceptive effect of morphine by centrally administered diazepam and midazolam.

Authors:  P Mantegazza; M Parenti; R Tammiso; P Vita; F Zambotti; N Zonta
Journal:  Br J Pharmacol       Date:  1982-04       Impact factor: 8.739

5.  Periaqueductal gray matter involvement in the muscimol-induced decrease of morphine antinociception.

Authors:  F Zambotti; N Zonta; M Parenti; R Tommasi; L Vicentini; F Conci; P Mantegazza
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1982-03       Impact factor: 3.000

6.  Diazepam enhances fentanyl and diminishes meperidine antinociception.

Authors:  S A Bergman; R L Wyn; G Williams
Journal:  Anesth Prog       Date:  1988 Sep-Oct

7.  Effects of some GABA-mimetic drugs on the antinociceptive activity of morphine and beta-endorphin in rats.

Authors:  N Zonta; F Zambotti; L Vicentini; R Tammiso; P Mantegazza
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1981-06       Impact factor: 3.000

8.  Effect of the NMDA-antagonist, MK 801, on benzodiazepine-opioid interactions at the spinal and supraspinal level in rats.

Authors:  T J Luger; I H Lorenz; C Grabner-Weiss; T Hayashi
Journal:  Br J Pharmacol       Date:  1995-03       Impact factor: 8.739

9.  Di-n-propylacetate-induced abstinence behaviour as a possible correlate of increased GABA-ergic activity in the rat.

Authors:  T de Boer; K Bartels; H J Metselaar; J Bruinvels
Journal:  Psychopharmacology (Berl)       Date:  1980       Impact factor: 4.530

Review 10.  Polydrug abuse: a review of opioid and benzodiazepine combination use.

Authors:  Jermaine D Jones; Shanthi Mogali; Sandra D Comer
Journal:  Drug Alcohol Depend       Date:  2012-08-02       Impact factor: 4.492
  10 in total

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