| Literature DB >> 6264484 |
A M Moriarty, B H Hoyer, J W Shih, J L Gerin, D H Hamer.
Abstract
We have constructed a simian virus 40 recombinant carrying a fragment of DNA from hepatitis B virus. Cultured monkey kidney cells infected with this recombinant produce hepatitis B surface antigen. The antigen is excreted into the culture medium as 22-nm particles with the same physical properties, antigenic composition, and constituent polypeptides as those found in the sera of patients with type B hepatitis.Entities:
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Year: 1981 PMID： 6264484 PMCID： PMC319398 DOI： 10.1073/pnas.78.4.2606
Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205