Literature DB >> 6259556

Myasthenia gravis: passive transfer to mice of antibody to human and mouse acetylcholine receptor.

K Oda, S Korenaga, Y Ito.   

Abstract

Mice were given intraperitoneal injections of serum from three patients with myasthenia gravis who had different titers of antibody against mouse acetylcholine receptor (AChR). Almost all mice treated with a high titer of serum antigens showed generalized paralysis, reduced amplitudes of miniature endplate potential (MEPP), or reduced numbers of AChRs. The effects were less marked in serum with lower titers of antibody to mouse AChR, when there was no relation to the severity of effects to the titer of antibody to human AChR.

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Year:  1981        PMID： 6259556     DOI： 10.1212/wnl.31.3.282

Source DB:  PubMed          Journal:  Neurology        ISSN： 0028-3878            Impact factor:   9.910


  9 in total

1.  Dysregulation of B Cell Repertoire Formation in Myasthenia Gravis Patients Revealed through Deep Sequencing.

Authors:  Jason A Vander Heiden; Panos Stathopoulos; Julian Q Zhou; Luan Chen; Tamara J Gilbert; Christopher R Bolen; Richard J Barohn; Mazen M Dimachkie; Emma Ciafaloni; Teresa J Broering; Francois Vigneault; Richard J Nowak; Steven H Kleinstein; Kevin C O'Connor
Journal:  J Immunol       Date:  2017-01-13       Impact factor: 5.422

Review 2.  Therapies Directed Against B-Cells and Downstream Effectors in Generalized Autoimmune Myasthenia Gravis: Current Status.

Authors:  Grayson Beecher; Brendan Nicholas Putko; Amanda Nicole Wagner; Zaeem Azfer Siddiqi
Journal:  Drugs       Date:  2019-03       Impact factor: 9.546

Review 3.  B cells in the pathophysiology of myasthenia gravis.

Authors:  John S Yi; Jeffrey T Guptill; Panos Stathopoulos; Richard J Nowak; Kevin C O'Connor
Journal:  Muscle Nerve       Date:  2017-09-30       Impact factor: 3.217

Review 4.  Novel pathophysiological insights in autoimmune myasthenia gravis.

Authors:  Gianvito Masi; Kevin C O'Connor
Journal:  Curr Opin Neurol       Date:  2022-08-04       Impact factor: 6.283

5.  Thymus-derived B cell clones persist in the circulation after thymectomy in myasthenia gravis.

Authors:  Ruoyi Jiang; Kenneth B Hoehn; Casey S Lee; Minh C Pham; Robert J Homer; Frank C Detterbeck; Inmaculada Aban; Leslie Jacobson; Angela Vincent; Richard J Nowak; Henry J Kaminski; Steven H Kleinstein; Kevin C O'Connor
Journal:  Proc Natl Acad Sci U S A       Date:  2020-11-16       Impact factor: 11.205

6.  Acetylcholine receptor turnover in mice with passively transferred myasthenia gravis. I. Receptor degradation.

Authors:  S Wilson; A Vincent; J Newsom-Davis
Journal:  J Neurol Neurosurg Psychiatry       Date:  1983-05       Impact factor: 10.154

7.  Autoreactive T Cells from Patients with Myasthenia Gravis Are Characterized by Elevated IL-17, IFN-γ, and GM-CSF and Diminished IL-10 Production.

Authors:  Yonghao Cao; Robert A Amezquita; Steven H Kleinstein; Panos Stathopoulos; Richard J Nowak; Kevin C O'Connor
Journal:  J Immunol       Date:  2016-01-29       Impact factor: 5.422

8.  Compromised fidelity of B-cell tolerance checkpoints in AChR and MuSK myasthenia gravis.

Authors:  Jae-Yun Lee; Panos Stathopoulos; Sasha Gupta; Jason M Bannock; Richard J Barohn; Elizabeth Cotzomi; Mazen M Dimachkie; Leslie Jacobson; Casey S Lee; Henner Morbach; Luis Querol; Jing-Li Shan; Jason A Vander Heiden; Patrick Waters; Angela Vincent; Richard J Nowak; Kevin C O'Connor
Journal:  Ann Clin Transl Neurol       Date:  2016-04-27       Impact factor: 4.511

Review 9.  Autoimmune Pathology in Myasthenia Gravis Disease Subtypes Is Governed by Divergent Mechanisms of Immunopathology.

Authors:  Miriam L Fichtner; Ruoyi Jiang; Aoibh Bourke; Richard J Nowak; Kevin C O'Connor
Journal:  Front Immunol       Date:  2020-05-27       Impact factor: 7.561
  9 in total

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