Literature DB >> 6101171

Acetylcholine receptor turnover in mice with passively transferred myasthenia gravis. I. Receptor degradation.

S Wilson1, A Vincent, J Newsom-Davis.   

Abstract

The in vivo degradation of endplate acetylcholine receptors was investigated in mice treated daily with IgG from 10 myasthenia gravis patients. Four preparations increased the rate of degradation. The number of endplate acetylcholine receptors after 7 days of IgG treatment was greater than that predicted on the basis of the increased degradation rate, suggesting a compensatory increase in receptor synthesis.

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Year:  1983        PMID： 6101171      PMCID： PMC1027382          DOI： 10.1136/jnnp.46.5.377

Source DB:  PubMed          Journal:  J Neurol Neurosurg Psychiatry        ISSN： 0022-3050            Impact factor:   10.154


  24 in total

1.  Turnover of junctional and extrajunctional acetylcholine receptors of the rat diaphragm.

Authors:  C C Chang; M C Huang
Journal:  Nature       Date:  1975-02-20       Impact factor: 49.962

2.  Neuromuscular transmission after immunization against acetylcholine receptors.

Authors:  D P Green; R Miledi; A Vincent
Journal:  Proc R Soc Lond B Biol Sci       Date:  1975-04-29

3.  Myasthenia gravis serum reduces acetylcholine sensitivity in cultured rat myotubes.

Authors:  R Anwyl; S M Appel; T Narahashi
Journal:  Nature       Date:  1977-05-19       Impact factor: 49.962

4.  Neuromuscular junction in myasthenia gravis: decreased acetylcholine receptors.

Authors:  D M Fambrough; D B Drachman; S Satyamurti
Journal:  Science       Date:  1973-10-19       Impact factor: 47.728

5.  Human myasthenic sera reduce acetylcholine sensitivity of human muscle cells in tissue culture.

Authors:  S Bevan; R W Kullberg; S F Heinemann
Journal:  Nature       Date:  1977-05-19       Impact factor: 49.962

6.  Loss of alpha-bungarotoxin from junctional and extrajunctional acetylcholine receptors in rat diaphragm muscle in vivo and in organ culture.

Authors:  D K Berg; Z W Hall
Journal:  J Physiol       Date:  1975-11       Impact factor: 5.182

7.  Antibody to acetylcholine receptor in myasthenia gravis. Prevalence, clinical correlates, and diagnostic value.

Authors:  J M Lindstrom; M E Seybold; V A Lennon; S Whittingham; D D Duane
Journal:  Neurology       Date:  1976-11       Impact factor: 9.910

8.  Myasthenia gravis. Study of humoral immune mechanisms by passive transfer to mice.

Authors:  K V Toyka; D B Drachman; D E Griffin; A Pestronk; J A Winkelstein; K H Fishbeck; I Kao
Journal:  N Engl J Med       Date:  1977-01-20       Impact factor: 91.245

9.  Acetylcholine receptor antibody characteristics in myasthenia gravis. I. Patients with generalized myasthenia or disease restricted to ocular muscles.

Authors:  A Vincent; J Newsom-Davis
Journal:  Clin Exp Immunol       Date:  1982-08       Impact factor: 4.330

10.  Acetylcholine receptor turnover in mice with passively transferred myasthenia gravis. II. Receptor synthesis.

Authors:  S Wilson; A Vincent; J Newsom-Davis
Journal:  J Neurol Neurosurg Psychiatry       Date:  1983-05       Impact factor: 10.154
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  2 in total

1.  Guidelines for pre-clinical assessment of the acetylcholine receptor--specific passive transfer myasthenia gravis model-Recommendations for methods and experimental designs.

Authors:  Linda L Kusner; Mario Losen; Angela Vincent; Jon Lindstrom; Socrates Tzartos; Konstantinos Lazaridis; Pilar Martinez-Martinez
Journal:  Exp Neurol       Date:  2015-03-03       Impact factor: 5.330

2.  Acetylcholine receptor turnover in mice with passively transferred myasthenia gravis. II. Receptor synthesis.

Authors:  S Wilson; A Vincent; J Newsom-Davis
Journal:  J Neurol Neurosurg Psychiatry       Date:  1983-05       Impact factor: 10.154
  2 in total

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