Literature DB >> 6256659

Nucleotide sequence and formation of the transforming gene of a mouse sarcoma virus.

C Van Beveren, J A Galleshaw, V Jonas, A J Berns, R F Doolittle, D J Donoghue, I M Verma.   

Abstract

The complete nucleotide sequence of the transforming gene of a mouse sarcoma virus has been determined. It codes for a protein of 374 amino acids. The nucleotide sequence of the junctions between a murine leukaemia virus and cellular sequences leading to the formation of the viral transforming gene have also been elucidated. The viral transforming sequence and its cellular homologue share an uninterrupted stretch of 1,159 nucleotides, with few base substitutions. The predicted amino acid sequence of the mouse sarcoma virus transforming gene was found to share considerable homology with the proposed amino acid sequence of the avian sarcoma virus oncogene (src) product.

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Year:  1981        PMID： 6256659     DOI： 10.1038/289258a0

Source DB:  PubMed          Journal:  Nature        ISSN： 0028-0836            Impact factor:   49.962


  72 in total

1.  Members of the src and ras oncogene families supplant the epidermal growth factor requirement of BALB/MK-2 keratinocytes and induce distinct alterations in their terminal differentiation program.

Authors:  B Weissman; S A Aaronson
Journal:  Mol Cell Biol       Date:  1985-12       Impact factor: 4.272

2.  v-mos protein produced by in vitro translation has protein kinase activity.

Authors:  N K Herzog; M Nash; L S Ramagli; R B Arlinghaus
Journal:  J Virol       Date:  1990-06       Impact factor: 5.103

3.  Features of the pp60v-src carboxyl terminus that are required for transformation.

Authors:  P Yaciuk; D Shalloway
Journal:  Mol Cell Biol       Date:  1986-08       Impact factor: 4.272

Review 4.  Evolution of a dynamic molecular switch.

Authors:  Susan S Taylor; Hiruy S Meharena; Alexandr P Kornev
Journal:  IUBMB Life       Date:  2019-05-06       Impact factor: 3.885

5.  Antibodies of predetermined specificity detect two retroviral oncogene products and inhibit their kinase activities.

Authors:  S Sen; R A Houghten; C J Sherr; A Sen
Journal:  Proc Natl Acad Sci U S A       Date:  1983-03       Impact factor: 11.205

6.  Studies on the pathology, especially brain lesions, induced by R7, a spontaneous mutant of Moloney murine sarcoma virus 124.

Authors:  P H Yuen; Y T Kwak
Journal:  Am J Pathol       Date:  1998-06       Impact factor: 4.307

7.  Comparison of myeloproliferative sarcoma virus with Moloney murine sarcoma virus variants by nucleotide sequencing and heteroduplex analysis.

Authors:  A Stacey; C Arbuthnott; R Kollek; L Coggins; W Ostertag
Journal:  J Virol       Date:  1984-06       Impact factor: 5.103

8.  Amino acid alterations within a highly conserved region of the Rous sarcoma virus src gene product pp60src inactivate tyrosine protein kinase activity.

Authors:  D L Bryant; J T Parsons
Journal:  Mol Cell Biol       Date:  1984-05       Impact factor: 4.272

9.  Molecular cloning and characterization of a leukemia-inducing myeloproliferative sarcoma virus and two of its temperature-sensitive mutants.

Authors:  R Kollek; C Stocking; F Smadja-Joffe; W Ostertag
Journal:  J Virol       Date:  1984-06       Impact factor: 5.103

10.  A novel oncogene, v-ryk, encoding a truncated receptor tyrosine kinase is transduced into the RPL30 virus without loss of viral sequences.

Authors:  R Jia; B J Mayer; T Hanafusa; H Hanafusa
Journal:  J Virol       Date:  1992-10       Impact factor: 5.103
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