Literature DB >> 3097514

Features of the pp60v-src carboxyl terminus that are required for transformation.

P Yaciuk, D Shalloway.   

Abstract

Analysis of the biological and biochemical activities of pp60recombinant-src proteins encoded by 12 carboxyl-terminal mutants showed that a wide family of alternate src carboxyl termini permit complete transforming and kinase activities. src proteins having carboxyl termini which are up to 10 amino acids longer than that of pp60c-src (17 amino acids longer than that of pp60v-src) still permit transformation. Transformation-positive mutations preserve leucine-516, a residue which is highly conserved in protein-tyrosine kinase sequences; removal causes in vivo protein instability. Successive deletion mutants show that this residue is at the boundary of a region required for kinase activity. pp60src which is truncated just outside this point still transforms cells and binds both pp50 and pp90 cellular proteins.

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Year:  1986        PMID： 3097514      PMCID： PMC367848          DOI： 10.1128/mcb.6.8.2807-2819.1986

Source DB:  PubMed          Journal:  Mol Cell Biol        ISSN： 0270-7306            Impact factor:   4.272


  60 in total

1.  Restriction of the in vitro and in vivo tyrosine protein kinase activities of pp60c-src relative to pp60v-src.

Authors:  P M Coussens; J A Cooper; T Hunter; D Shalloway
Journal:  Mol Cell Biol       Date:  1985-10       Impact factor: 4.272

2.  Nucleotide sequence of Rous sarcoma virus.

Authors:  D E Schwartz; R Tizard; W Gilbert
Journal:  Cell       Date:  1983-03       Impact factor: 41.582

3.  Separation of multiple phosphotyrosyl-and phosphoseryl-protein phosphatases from chicken brain.

Authors:  J G Foulkes; E Erikson; R L Erikson
Journal:  J Biol Chem       Date:  1983-01-10       Impact factor: 5.157

4.  Corrections to the nucleotide sequence of the src gene of Rous sarcoma virus.

Authors:  A P Czernilofsky; A D Levinson; H E Varmus; J M Bishop; E Tischer; H Goodman
Journal:  Nature       Date:  1983-02-24       Impact factor: 49.962

5.  Antibodies to a defined region of pp60src neutralize the tyrosine-specific kinase activity.

Authors:  L E Gentry; L R Rohrschneider; J E Casnellie; E G Krebs
Journal:  J Biol Chem       Date:  1983-09-25       Impact factor: 5.157

6.  Revised sequence of the tetracycline-resistance gene of pBR322.

Authors:  K W Peden
Journal:  Gene       Date:  1983 May-Jun       Impact factor: 3.688

7.  Regulatory sequences and virus-cell interactions of JC virus.

Authors:  R J Frisque
Journal:  Prog Clin Biol Res       Date:  1983

8.  Structure and sequence of the cellular gene homologous to the RSV src gene and the mechanism for generating the transforming virus.

Authors:  T Takeya; H Hanafusa
Journal:  Cell       Date:  1983-03       Impact factor: 41.582

9.  Nucleotide sequence of Abelson murine leukemia virus genome: structural similarity of its transforming gene product to other onc gene products with tyrosine-specific kinase activity.

Authors:  E P Reddy; M J Smith; A Srinivasan
Journal:  Proc Natl Acad Sci U S A       Date:  1983-06       Impact factor: 11.205

10.  Transduction of a cellular oncogene: the genesis of Rous sarcoma virus.

Authors:  R Swanstrom; R C Parker; H E Varmus; J M Bishop
Journal:  Proc Natl Acad Sci U S A       Date:  1983-05       Impact factor: 11.205
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  16 in total

1.  Role of p34cdc2-mediated phosphorylations in two-step activation of pp60c-src during mitosis.

Authors:  S Shenoy; I Chackalaparampil; S Bagrodia; P H Lin; D Shalloway
Journal:  Proc Natl Acad Sci U S A       Date:  1992-08-01       Impact factor: 11.205

2.  cDNA cloning and characterization of eck, an epithelial cell receptor protein-tyrosine kinase in the eph/elk family of protein kinases.

Authors:  R A Lindberg; T Hunter
Journal:  Mol Cell Biol       Date:  1990-12       Impact factor: 4.272

3.  Sequence and functional differences between Schmidt-Ruppin D and Schmidt-Ruppin A strains of pp60v-src.

Authors:  S Reddy; D Mazzu; D Mahan; D Shalloway
Journal:  J Virol       Date:  1990-07       Impact factor: 5.103

4.  Efficient transformation by Prague A Rous sarcoma virus plasmid DNA requires the presence of cis-acting regions within the gag gene.

Authors:  C M Stoltzfus; L J Chang; T P Cripe; L P Turek
Journal:  J Virol       Date:  1987-11       Impact factor: 5.103

5.  v-src mutations outside the carboxyl-coding region are not sufficient to fully activate transformation by pp60c-src in NIH 3T3 cells.

Authors:  S Reddy; P Yaciuk; T E Kmiecik; P M Coussens; D Shalloway
Journal:  Mol Cell Biol       Date:  1988-02       Impact factor: 4.272

6.  The carboxy terminus of pp60c-src is a regulatory domain and is involved in complex formation with the middle-T antigen of polyomavirus.

Authors:  S H Cheng; H Piwnica-Worms; R W Harvey; T M Roberts; A E Smith
Journal:  Mol Cell Biol       Date:  1988-04       Impact factor: 4.272

7.  Structural differences between repressed and derepressed forms of p60c-src.

Authors:  A MacAuley; J A Cooper
Journal:  Mol Cell Biol       Date:  1989-06       Impact factor: 4.272

8.  Transduction of the cellular src gene and 3' adjacent sequences in avian sarcoma virus PR2257.

Authors:  J Geryk; P Dezélée; J V Barnier; J Svoboda; J Nehyba; I Karakoz; A V Rynditch; B A Yatsula; G Calothy
Journal:  J Virol       Date:  1989-02       Impact factor: 5.103

9.  Primary sequence and developmental expression of a novel Drosophila melanogaster src gene.

Authors:  R J Gregory; K L Kammermeyer; W S Vincent; S G Wadsworth
Journal:  Mol Cell Biol       Date:  1987-06       Impact factor: 4.272

10.  Myristylation is required for Tyr-527 dephosphorylation and activation of pp60c-src in mitosis.

Authors:  S Bagrodia; S J Taylor; D Shalloway
Journal:  Mol Cell Biol       Date:  1993-03       Impact factor: 4.272
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