Literature DB >> 6255083

Biological properties of polyoma DNA fragments cloned in plasmid pBR322.

M Bastin, D Bourgaux-Ramoisy, P Bourgaux.   

Abstract

The two HindIII fragments of polyoma virus DNA were cloned in the HindIII site of plasmid pBR322, and the biological activity of the recombinant plasmids was tested in tissue culture cells. A mixture of recombinant plasmids containing the HindIII-A and HindIII-B fragments was infectious, but only after cleavage with HindIII. Recombinant plasmids containing the HindIII-A fragment, but not those containing the HindIII-B fragment, induced the transformation of Fischer rat 3T3 cells. These findings indicate that about half of the early region of polyoma virus DNA is not essential for the initiation of the maintenance of transformation.

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Year:  1980        PMID： 6255083     DOI： 10.1099/0022-1317-50-1-179

Source DB:  PubMed          Journal:  J Gen Virol        ISSN： 0022-1317            Impact factor:   3.891


  9 in total

1.  Tumorigenic activity of cloned polyoma virus DNA in newborn rats.

Authors:  C Gélinas; L Bouchard; M Bastin
Journal:  Experientia       Date:  1981-10-15

2.  Requirement for the C-terminal region of middle T-antigen in cellular transformation by polyoma virus.

Authors:  U Novak; B E Griffin
Journal:  Nucleic Acids Res       Date:  1981-05-11       Impact factor: 16.971

3.  Inducible permissive cells transformed by a temperature-sensitive polyoma virus: superinfection does not allow excision of the resident viral genome.

Authors:  L Delbecchi; D Gendron; P Bourgaux
Journal:  J Virol       Date:  1981-07       Impact factor: 5.103

4.  A 61,000-dalton truncated large T-antigen is uniformly expressed in hamster cells transformed by polyomavirus.

Authors:  V Rey-Bellet; H Türler
Journal:  J Virol       Date:  1984-05       Impact factor: 5.103

5.  Recombinant retroviruses encoding simian virus 40 large T antigen and polyomavirus large and middle T antigens.

Authors:  P S Jat; C L Cepko; R C Mulligan; P A Sharp
Journal:  Mol Cell Biol       Date:  1986-04       Impact factor: 4.272

6.  Alternative excision products originating from a single integration of polyomavirus DNA.

Authors:  D Huberdeau; B S Sylla; E Herring-Gillam; D Bourgaux-Ramoisy; P Bourgaux
Journal:  Mol Cell Biol       Date:  1985-10       Impact factor: 4.272

7.  Polyoma middle T antigen requires cooperation from another gene to express the malignant phenotype in vivo.

Authors:  C Asselin; C Gélinas; P E Branton; M Bastin
Journal:  Mol Cell Biol       Date:  1984-04       Impact factor: 4.272

8.  Polyoma virus mutant with normal transforming ability but impaired tumorigenic potential.

Authors:  C Gelinas; P Chartrand; M Bastin
Journal:  J Virol       Date:  1982-09       Impact factor: 5.103

9.  Role of the three polyoma virus early proteins in tumorigenesis.

Authors:  C Asselin; C Gelinas; M Bastin
Journal:  Mol Cell Biol       Date:  1983-08       Impact factor: 4.272
  9 in total

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