Literature DB >> 6254031

Genomic organization of rat prolactin and growth hormone genes.

Y H Chien, E B Thompson.   

Abstract

Five overlapping cloned DNAs containing the rat prolactin gene and its flanking sequences, as well as one cloned DNA containing the rat growth hormone gene and its flanking sequences, were isolated from a chromosomal DNA library. They were characterized by restriction enzyme mapping and electron microscopy. In each gene, the structural gene sequence coding for mature mRNA of a length of about 1 kilobase is split into at least five segments by a minimum of four intervening sequences. The two genes are similar in the length and organization of their coding regions, consistent with the suggestion that they are derived from a common ancestral gene. However, the two genes differ greatly in the lengths of their intervening sequences. That leads to a total gene length of 10 kilobase pairs for the prolactin and 2.1 kilobase pairs for the growth hormone gene. At least one intervening sequence appears to be in the 5' nontranslated regions of the prolactin and growth hormone mRNA coding sequences.

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Year:  1980        PMID： 6254031      PMCID： PMC349888          DOI： 10.1073/pnas.77.8.4583

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  24 in total

1.  Rapid isolation of antigens from cells with a staphylococcal protein A-antibody adsorbent: parameters of the interaction of antibody-antigen complexes with protein A.

Authors:  S W Kessler
Journal:  J Immunol       Date:  1975-12       Impact factor: 5.422

2.  High resolution two-dimensional electrophoresis of proteins.

Authors:  P H O'Farrell
Journal:  J Biol Chem       Date:  1975-05-25       Impact factor: 5.157

3.  An amazing sequence arrangement at the 5' ends of adenovirus 2 messenger RNA.

Authors:  L T Chow; R E Gelinas; T R Broker; R J Roberts
Journal:  Cell       Date:  1977-09       Impact factor: 41.582

4.  Pregrowth hormone messenger RNA: glucocorticoid induction and identification in rat pituitary cells.

Authors:  R J Tushinski; P M Sussman; L Y Yu; F C Bancroft
Journal:  Proc Natl Acad Sci U S A       Date:  1977-06       Impact factor: 11.205

5.  Screening lambdagt recombinant clones by hybridization to single plaques in situ.

Authors:  W D Benton; R W Davis
Journal:  Science       Date:  1977-04-08       Impact factor: 47.728

6.  Polyadenylic acid-containing RNA in Xenopus laevis oocytes.

Authors:  M Rosbash
Journal:  J Mol Biol       Date:  1974-05-05       Impact factor: 5.469

7.  Thyrotropin-releasing hormone increases prolactin mRNA activity in the cytoplasm of GH-cells as measured by translation in a wheat germ cell-free system.

Authors:  P S Dannies; A H Tashjian
Journal:  Biochem Biophys Res Commun       Date:  1976-06-21       Impact factor: 3.575

8.  Rat insulin genes: construction of plasmids containing the coding sequences.

Authors:  A Ullrich; J Shine; J Chirgwin; R Pictet; E Tischer; W J Rutter; H M Goodman
Journal:  Science       Date:  1977-06-17       Impact factor: 47.728

9.  Mapping of poly(A) sequences in the electron microscope reveals unusual structure of type C oncornavirus RNA molecules.

Authors:  W Bender; N Davidson
Journal:  Cell       Date:  1976-04       Impact factor: 41.582

10.  Triiodothyronine stimulates specifically growth hormone mRNA in rat pituitary tumor cells.

Authors:  H Seo; G Vassart; H Brocas; S Refetoff
Journal:  Proc Natl Acad Sci U S A       Date:  1977-05       Impact factor: 11.205
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  17 in total

1.  Do exons code for structural or functional units in proteins?

Authors:  T W Traut
Journal:  Proc Natl Acad Sci U S A       Date:  1988-05       Impact factor: 11.205

2.  Novel restriction fragment length polymorphism of the growth hormone gene in inbred rats.

Authors:  T Kunieda; H Ikadai; M Matsui; N Nomura; T Imamichi; R Ishizaki
Journal:  Biochem Genet       Date:  1989-10       Impact factor: 1.890

3.  Repetitive DNA sequences within and around the rat prolactin gene.

Authors:  J L Weber; L K Durrin; J Gorski
Journal:  Mol Cell Biochem       Date:  1985-01       Impact factor: 3.396

4.  Induction of prolactin-deficient variants of GH3 rat pituitary tumor cells by ethyl methanesulfonate: reversion by 5-azacytidine, a DNA methylation inhibitor.

Authors:  R D Ivarie; J A Morris
Journal:  Proc Natl Acad Sci U S A       Date:  1982-05       Impact factor: 11.205

5.  DNA sequence of the rat growth hormone gene: location of the 5' terminus of the growth hormone mRNA and identification of an internal transposon-like element.

Authors:  G S Page; S Smith; H M Goodman
Journal:  Nucleic Acids Res       Date:  1981-05-11       Impact factor: 16.971

6.  Glucocorticoid and thyroid hormones transcriptionally regulate growth hormone gene expression.

Authors:  R M Evans; N C Birnberg; M G Rosenfeld
Journal:  Proc Natl Acad Sci U S A       Date:  1982-12       Impact factor: 11.205

7.  Cell-type-specific cDNA probes and the murine I region: the localization and orientation of Ad alpha.

Authors:  M M Davis; D I Cohen; E A Nielsen; M Steinmetz; W E Paul; L Hood
Journal:  Proc Natl Acad Sci U S A       Date:  1984-04       Impact factor: 11.205

8.  Structure of a human gastrin gene.

Authors:  O Wiborg; L Berglund; E Boel; F Norris; K Norris; J F Rehfeld; K A Marcker; J Vuust
Journal:  Proc Natl Acad Sci U S A       Date:  1984-02       Impact factor: 11.205

9.  The growth hormone-encoding gene isolated and characterized from Labeo rohita Hamilton is expressed in CHO cells under the control of constitutive promoters in 'autotransgene' constructs.

Authors:  R Rajesh; K C Majumdar
Journal:  Fish Physiol Biochem       Date:  2008-02-07       Impact factor: 2.794

10.  Prolactin-deficient variants of GH3 rat pituitary tumor cells: linked expression of prolactin and another hormonally responsive protein in GH3 cells.

Authors:  R D Ivarie; J A Morris; J A Martial
Journal:  Mol Cell Biol       Date:  1982-02       Impact factor: 4.272
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