Literature DB >> 6253886

Temporal regulation of herpes simplex virus type 2 transcription and characterization of virus immediate early mRNA's.

A J Easton, J B Clements.   

Abstract

Nuclear and cytoplasmic virus RNAs, synthesized in cells infected with herpes simplex virus type 2 at early and late times post-infection, and in the continuous presence of the protein synthesis inhibitor cycloheximide (immediate early), have been analyzed by blot hybridization to virus DNA fragments generated by Bam HI and Eco RI restriction endonucleases. Polyadenylated immediate early mRNAs were separated on denaturing gels containing CH3HgOH giving three virus-specific mRNA bands of estimated sizes 4.7, 3.4 and 1.75 kb, and these have been mapped to five discrete regions of the genome. The polypeptides produced by in vitro translation of the HSV-2 immediate early mRNA's have been identified. Orientations of immediate early mRNA's on the virus genome have been determined by mapping cDNAs complementary to the 3'termini of the mRNAs.

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Year:  1980        PMID： 6253886      PMCID： PMC324110          DOI： 10.1093/nar/8.12.2627

Source DB:  PubMed          Journal:  Nucleic Acids Res        ISSN： 0305-1048            Impact factor:   16.971


  41 in total

1.  Ribonucleic acid synthesis in cells infected with herpes simplex virus: controls of transcription and of RNA abundance.

Authors:  N Frenkel; B Roizman
Journal:  Proc Natl Acad Sci U S A       Date:  1972-09       Impact factor: 11.205

2.  Genetic interactions between temperature-sensitive mutants of types 1 and 2 herpes simplex viruses.

Authors:  M C Timbury; J H Subak-Sharpe
Journal:  J Gen Virol       Date:  1973-03       Impact factor: 3.891

3.  Studies on the relatedness of herpesviruses through DNA-DNA hybridization.

Authors:  H O Ludwig; N Biswal; M Benyesh-Melnick
Journal:  Virology       Date:  1972-07       Impact factor: 3.616

4.  Herpes simplex virus DNA.

Authors:  Y Becker; H Dym; I Sarov
Journal:  Virology       Date:  1968-10       Impact factor: 3.616

5.  Characterization of messenger ribonucleoprotein and messenger RNA from KB cells.

Authors:  A Kumar; U Lindberg
Journal:  Proc Natl Acad Sci U S A       Date:  1972-03       Impact factor: 11.205

6.  A complementation analysis of the restriction and modification of DNA in Escherichia coli.

Authors:  H W Boyer; D Roulland-Dussoix
Journal:  J Mol Biol       Date:  1969-05-14       Impact factor: 5.469

7.  RNA synthesis in cells infected with herpes simplex virus. VII. Control of transcription and of transcript abundancies of unique and common sequences of herpes simplex virus 1 and 2.

Authors:  N Frenkel; S Silverstein; E Cassai; B Roizman
Journal:  J Virol       Date:  1973-06       Impact factor: 5.103

8.  Size, composition, and structure of the deoxyribonucleic acid of herpes simplex virus subtypes 1 and 2.

Authors:  E D Kieff; S L Bachenheimer; B Roizman
Journal:  J Virol       Date:  1971-08       Impact factor: 5.103

9.  Properties of hamster embryo fibroblasts transformed in vitro after exposure to ultraviolet-irradiated herpes simplex virus type 2.

Authors:  R Duff; F Rapp
Journal:  J Virol       Date:  1971-10       Impact factor: 5.103

10.  Genetic relatedness of type 1 and type 2 herpes simplex viruses.

Authors:  E Kieff; B Hoyer; S Bachenheimer; B Roizman
Journal:  J Virol       Date:  1972-05       Impact factor: 5.103
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  15 in total

Review 1.  Molecular biology of cytomegalovirus.

Authors:  V C Emery; P D Griffiths
Journal:  Int J Exp Pathol       Date:  1990-12       Impact factor: 1.925

2.  Temporal regulation of human cytomegalovirus transcription at immediate early and early times after infection.

Authors:  M W Wathen; D R Thomsen; M F Stinski
Journal:  J Virol       Date:  1981-05       Impact factor: 5.103

3.  A 3' co-terminus of two early herpes simplex virus type 1 mRNAs.

Authors:  J McLauchlan; J B Clements
Journal:  Nucleic Acids Res       Date:  1982-01-22       Impact factor: 16.971

4.  Organization and expression of the immediate early genes of human cytomegalovirus.

Authors:  M F Stinski; D R Thomsen; R M Stenberg; L C Goldstein
Journal:  J Virol       Date:  1983-04       Impact factor: 5.103

5.  Temporal patterns of human cytomegalovirus transcription: mapping the viral RNAs synthesized at immediate early, early, and late times after infection.

Authors:  M W Wathen; M F Stinski
Journal:  J Virol       Date:  1982-02       Impact factor: 5.103

6.  Detailed structural analysis of two spliced HSV-1 immediate-early mRNAs.

Authors:  F J Rixon; J B Clements
Journal:  Nucleic Acids Res       Date:  1982-04-10       Impact factor: 16.971

7.  Analysis of DNA sequences which regulate the transcription of a herpes simplex virus immediate early gene.

Authors:  C M Preston; M G Cordingley; N D Stow
Journal:  J Virol       Date:  1984-06       Impact factor: 5.103

8.  Mutants defective in herpes simplex virus type 2 ICP4: isolation and preliminary characterization.

Authors:  C A Smith; P A Schaffer
Journal:  J Virol       Date:  1987-04       Impact factor: 5.103

9.  Replication origins and a sequence involved in coordinate induction of the immediate-early gene family are conserved in an intergenic region of herpes simplex virus.

Authors:  J L Whitton; J B Clements
Journal:  Nucleic Acids Res       Date:  1984-02-24       Impact factor: 16.971

10.  Expression of cloned herpesvirus genes. I. Detection of nuclear antigens from herpes simplex virus type 2 inverted repeat regions in transfected mouse cells.

Authors:  M H Middleton; G R Reyes; D M Ciufo; A Buchan; J C Macnab; G S Hayward
Journal:  J Virol       Date:  1982-09       Impact factor: 5.103
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