| Literature DB >> 625323 |
Y L Lyubchenko, A V Vologodskii, M D Frank-Kamenetskii.
Abstract
The determination by Sanger et al. of the comple nucleotide sequence for phiX174 DNA has made it possible for the first time to compare directly theoretical and experimental DNA melting profiles. The comparison shows that the theory predicts the observed shape of the differential melting curve surprisingly well. Calculation of the denaturation maps allows the peaks on the curve to be correlated with cooperative melting out of concrete regions on the sequence of nucleotides.Mesh：
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Year: 1978 PMID： 625323 DOI： 10.1038/271028a0
Source DB: PubMed Journal: Nature ISSN： 0028-0836 Impact factor: 49.962